chr19:23,277,685–23,278,396

chr19 : 23,277,685 – 23,278,396

711 bp 71 TFs 8 linked genes

This 711 bp open chromatin element is linked to 8 target genes and is bound by 71 transcription factors.

Linked Genes

8 genes

Gene	Expression	Dist. to TSS	Distance	Link type
ENSG00000284428		3.4 kb	Proximal	Proximity
ENSG00000269107		3.5 kb	Proximal	Proximity
ZNF724		3.5 kb	Proximal	Proximity
ZNF91		117.4 kb	Distal	Multiome+HiCAR
LINC01224		138.0 kb	Distal	Multiome
ZNF730		202.8 kb	Distal	Multiome
ZNF254		755.4 kb	Distal	Multiome+HiCAR
ENSG00000268362		755.4 kb	Distal	Multiome+HiCAR

Chromatin Accessibility

Genome Browser

Genomic view centred on this element. Tracks include ATAC-seq accessibility, RNA-seq expression, TF binding peaks, and element-to-gene loop arcs across the ESC → DE time course.

Transcription factors with ChIP-seq peak overlap or TOBIAS motif footprint evidence at this element.

TF Binding

71 transcription factors

ARID3A 1 dataset

ChIP HepG2 ENCFF341DES 320 bp overlap

ARID4A 1 dataset

ChIP HepG2 ENCFF142DIE 711 bp overlap

ARID5B 1 dataset

ChIP HepG2 ENCFF964FWK 154 bp overlap

CEBPA 1 dataset

ChIP HepG2 ENCFF175DFS 203 bp overlap

Cebpa 1 dataset

ChIP BLaER1 ENCFF262VBH 249 bp overlap

Motif DE_72h DE_72h-ELF1_MA0473.4 9 bp overlap

ERF::SREBF2 2 datasets

Motif DE_60h DE_60h-ERFSREBF2_MA1939.2 16 bp overlap

Motif DE_72h DE_72h-ERFSREBF2_MA1939.2 16 bp overlap

ChIP cardiomyocyte_D9 GSE129986.ETS1.cardiomyocyte_D9 127 bp overlap

ETV2::FIGLA 1 dataset

Motif DE_60h DE_60h-ETV2FIGLA_MA1941.2 13 bp overlap

ChIP HepG2 ENCFF456LSA 219 bp overlap

ETV5::FIGLA 1 dataset

Motif DE_60h DE_60h-ETV5FIGLA_MA1945.2 14 bp overlap

FOXA1 3 datasets

ChIP HepG2 ENCFF207NVJ 179 bp overlap

ChIP HepG2 ENCFF361KNY 175 bp overlap

ChIP HepG2 ENCFF740VZW 178 bp overlap

FOXA2 5 datasets

ChIP DE DE-FOXA2-1 711 bp overlap

ChIP DE DE-FOXA2-2 711 bp overlap

ChIP HepG2 ENCFF533COJ 187 bp overlap

ChIP HepG2 ENCFF570ABM 157 bp overlap

ChIP HepG2 ENCFF894AYY 156 bp overlap

FOXA3 1 dataset

ChIP HepG2 ENCFF005KGL 203 bp overlap

FOXO1::ELK1 1 dataset

Motif DE_72h DE_72h-FOXO1ELK1_MA1954.2 13 bp overlap

GATA1::TAL1 1 dataset

Motif DE_72h DE_72h-GATA1TAL1_MA0140.3 17 bp overlap

GATA2 1 dataset

Motif DE_72h DE_72h-GATA2_MA0036.4 7 bp overlap

GATA4 8 datasets

ChIP DE DE-GATA4-1 643 bp overlap

ChIP DE DE-GATA4-2 653 bp overlap

Motif DE_72h DE_72h-GATA4_MA0482.3 8 bp overlap

Motif DE_72h DE_72h-GATA4_MA0482.3 8 bp overlap

ChIP HepG2 ENCFF309FOQ 283 bp overlap

ChIP foregut GSE117136.GATA4.foregut 267 bp overlap

ChIP pancreatic-progenitor GSE117136.GATA4.pancreatic-progenitor 517 bp overlap

ChIP pancreatic-progenitor_PP1 GSE104840.GATA4.pancreatic-progenitor_PP1 225 bp overlap

GATA5 2 datasets

Motif DE_72h DE_72h-GATA5_MA0766.3 8 bp overlap

Motif DE_72h DE_72h-GATA5_MA0766.3 8 bp overlap

GATA6 9 datasets

ChIP DE DE-GATA6-1 626 bp overlap

ChIP DE DE-GATA6-2 663 bp overlap

Motif DE_72h DE_72h-GATA6_MA1104.3 8 bp overlap

Motif DE_72h DE_72h-GATA6_MA1104.3 8 bp overlap

ChIP DE_D2 S55-DE-d2-GATA6-exp2 711 bp overlap

ChIP foregut GSE117136.GATA6.foregut 488 bp overlap

ChIP pancreatic-progenitor GSE117136.GATA6.pancreatic-progenitor 375 bp overlap

ChIP pancreatic-progenitor_KO GSE117136.GATA6.pancreatic-progenitor_KO 319 bp overlap

ChIP pancreatic-progenitor_PP1 GSE104840.GATA6.pancreatic-progenitor_PP1 220 bp overlap

GATAD2A 1 dataset

ChIP HepG2 ENCFF252XNH 286 bp overlap

Gata3 2 datasets

Motif DE_72h DE_72h-Gata3_MA0037.5 8 bp overlap

Motif DE_72h DE_72h-Gata3_MA0037.5 8 bp overlap

HAND2 2 datasets

Motif DE_60h DE_60h-HAND2_MA1638.2 6 bp overlap

Motif DE_72h DE_72h-HAND2_MA1638.2 6 bp overlap

HDAC2 1 dataset

ChIP HepG2 ENCFF990GUQ 266 bp overlap

HMG20A 1 dataset

ChIP HepG2 ENCFF599VWU 329 bp overlap

HNF1A 2 datasets

ChIP HepG2 ENCFF352VYI 240 bp overlap

ChIP HepG2 ENCFF540TRC 380 bp overlap

HOMEZ 1 dataset

ChIP HepG2 ENCFF800ZQH 231 bp overlap

HOXA3 1 dataset

ChIP HepG2 ENCFF374TCI 409 bp overlap

IKZF1 1 dataset

Motif DE_72h DE_72h-IKZF1_MA1508.2 8 bp overlap

IKZF2 2 datasets

Motif DE_60h DE_60h-IKZF2_MA2326.1 6 bp overlap

Motif DE_72h DE_72h-IKZF2_MA2326.1 6 bp overlap

IKZF5 1 dataset

ChIP HepG2 ENCFF641EBK 377 bp overlap

Motif DE_72h DE_72h-ISL2_MA0914.2 6 bp overlap

ChIP HepG2 ENCFF507HCX 402 bp overlap

MEF2D 1 dataset

ChIP HepG2 ENCFF576WDO 373 bp overlap

Motif DE_72h DE_72h-MYB_MA0100.4 6 bp overlap

MYOD1 2 datasets

Motif DE_60h DE_60h-MYOD1_MA0499.3 9 bp overlap

Motif DE_72h DE_72h-MYOD1_MA0499.3 9 bp overlap

Mecom 1 dataset

Motif DE_72h DE_72h-Mecom_MA0029.2 11 bp overlap

NEUROD1 2 datasets

Motif DE_60h DE_60h-NEUROD1_MA1109.2 8 bp overlap

Motif DE_72h DE_72h-NEUROD1_MA1109.2 8 bp overlap

NEUROG2 2 datasets

Motif DE_60h DE_60h-NEUROG2_MA0669.1 10 bp overlap

Motif DE_72h DE_72h-NEUROG2_MA0669.1 10 bp overlap

Neurod2 2 datasets

Motif DE_60h DE_60h-Neurod2_MA0668.3 8 bp overlap

Motif DE_72h DE_72h-Neurod2_MA0668.3 8 bp overlap

Nkx3-2 1 dataset

Motif DE_72h DE_72h-Nkx3-2_MA0122.4 10 bp overlap

ONECUT1 1 dataset

ChIP HepG2 ENCFF243FIR 204 bp overlap

ONECUT2 1 dataset

ChIP HepG2 ENCFF460COO 183 bp overlap

PAXIP1 1 dataset

ChIP HepG2 ENCFF526NOJ 329 bp overlap

PITX1 1 dataset

ChIP HepG2 ENCFF468QTQ 174 bp overlap

POLR2A 1 dataset

ChIP prostate gland ENCFF881OMH 153 bp overlap

PPARG 1 dataset

Motif DE_72h DE_72h-PPARG_MA0066.2 19 bp overlap

Ptf1A 2 datasets

Motif DE_60h DE_60h-Ptf1A_MA1618.2 9 bp overlap

Motif DE_72h DE_72h-Ptf1A_MA1618.2 9 bp overlap

SALL1 1 dataset

ChIP HepG2 ENCFF426MCK 400 bp overlap

SAP130 1 dataset

ChIP HepG2 ENCFF892EHZ 159 bp overlap

ChIP HepG2 ENCFF587VYG 217 bp overlap

SMAD2_3 2 datasets

ChIP DE_D2 S01-DE-d2-SMAD2_3-exp1 331 bp overlap

ChIP DE_D2 S53-DE-d2-SMAD2_3-exp2 543 bp overlap

SOX13 1 dataset

ChIP HepG2 ENCFF062VSQ 143 bp overlap

SOX17_M 1 dataset

ChIP DE_D2 DED2-SOX17-M_Batch_II 481 bp overlap

ChIP HepG2 ENCFF470KZD 254 bp overlap

ChIP HepG2 ENCFF767OCK 428 bp overlap

ChIP HepG2 ENCFF123KAM 107 bp overlap

SPIB 2 datasets

Motif DE_60h DE_60h-SPIB_MA0081.3 13 bp overlap

Motif DE_72h DE_72h-SPIB_MA0081.3 13 bp overlap

Motif DE_72h DE_72h-SPIC_MA0687.2 13 bp overlap

Spi1 2 datasets

Motif DE_60h DE_60h-Spi1_MA0080.7 13 bp overlap

Motif DE_72h DE_72h-Spi1_MA0080.7 13 bp overlap

TEAD1 2 datasets

Motif DE_72h DE_72h-TEAD1_MA0090.4 9 bp overlap

ChIP HepG2 ENCFF661PNM 219 bp overlap

TEAD3 1 dataset

Motif DE_72h DE_72h-TEAD3_MA0808.1 8 bp overlap

TFAP4::ETV1 1 dataset

Motif DE_60h DE_60h-TFAP4ETV1_MA1966.2 13 bp overlap

TRPS1 2 datasets

Motif DE_72h DE_72h-TRPS1_MA1970.2 8 bp overlap

Motif DE_72h DE_72h-TRPS1_MA1970.2 8 bp overlap

ChIP HepG2 ENCFF016NZF 593 bp overlap

ChIP HepG2 ENCFF106ELT 515 bp overlap

ZNF292 1 dataset

ChIP HepG2 ENCFF975MAJ 355 bp overlap

ZNF512B 1 dataset

ChIP HepG2 ENCFF126PJB 373 bp overlap

ZNF614 1 dataset

ChIP HepG2 ENCFF677IUD 346 bp overlap

ZNF792 1 dataset

ChIP HepG2 ENCFF825WPU 379 bp overlap

ZSCAN4 1 dataset

Motif DE_72h DE_72h-ZSCAN4_MA1155.1 15 bp overlap