chr21 : 33,651,077 – 33,651,511

434 bp 61 TFs 2 linked genes

This 434 bp open chromatin element is linked to ITSN1 and CRYZL1 and is bound by 61 transcription factors.

Linked Genes

2 genes

Gene	Expression	Dist. to TSS	Distance	Link type
ITSN1		8.6 kb	Proximal	Proximity
CRYZL1		8.7 kb	Proximal	Proximity

Chromatin Accessibility

Genome Browser

Genomic view centred on this element. Tracks include ATAC-seq accessibility, RNA-seq expression, TF binding peaks, and element-to-gene loop arcs across the ESC → DE time course.

Transcription factors with ChIP-seq peak overlap or TOBIAS motif footprint evidence at this element.

TF Binding

61 transcription factors

ARID1A 1 dataset

ChIP 12Z GSE129781.ARID1A.12Z 257 bp overlap

BRD2 1 dataset

ChIP MV4-11_IBET151_500nM GSE120715.BRD2.MV4-11_IBET151_500nM 129 bp overlap

BRD4 4 datasets

ChIP HEK293T GSE39579.BRD4.HEK293T 281 bp overlap

ChIP HEK293_sgNT GSE129407.BRD4.HEK293_sgNT 170 bp overlap

ChIP RH4_shCHD4 GSE140115.BRD4.RH4_shCHD4 137 bp overlap

ChIP RH4_shscr GSE140115.BRD4.RH4_shscr 208 bp overlap

CBX8 1 dataset

ChIP K-562 ENCSR000ATW.CBX8.K-562 374 bp overlap

CHD7 1 dataset

ChIP hiPSC_derived_lt-NES GSE108506.CHD7.hiPSC_derived_lt-NES 191 bp overlap

EGR1 1 dataset

ChIP Hep-G2 ENCSR026GSW.EGR1.Hep-G2 208 bp overlap

EOMES 1 dataset

ChIP hESC GSE26097.EOMES.hESC 150 bp overlap

ESR1 3 datasets

ChIP Ishikawa_E2-1h GSE129803.ESR1.Ishikawa_E2-1h 139 bp overlap

ChIP MCF-7_shFbxo_E2_4OHT GSE119702.ESR1.MCF-7_shFbxo_E2_4OHT 114 bp overlap

ChIP MCF-7_shFbxo_OHT GSE119702.ESR1.MCF-7_shFbxo_OHT 114 bp overlap

FLI1 1 dataset

ChIP SKNO-1 GSE23730.FLI1.SKNO-1 145 bp overlap

FOXA2 4 datasets

ChIP BJ1-hTERT_MimoRelease GSE92491.FOXA2.BJ1-hTERT_MimoRelease 136 bp overlap

ChIP Caco-2 GSE66218.FOXA2.Caco-2 97 bp overlap

ChIP DE DE-FOXA2-1 434 bp overlap

ChIP DE DE-FOXA2-2 434 bp overlap

FOXL2 2 datasets

ChIP KGN_1513 GSE138496.FOXL2.KGN_1513 189 bp overlap

ChIP SVOG-3e_DOX-WT GSE126171.FOXL2.SVOG-3e_DOX-WT 237 bp overlap

GATA2 3 datasets

ChIP ESF GSE108408.GATA2.ESF 189 bp overlap

ChIP ME-1_CBFB-MYH11-KD GSE117138.GATA2.ME-1_CBFB-MYH11-KD 83 bp overlap

ChIP hiPSC_SLC6ebs GSE107639.GATA2.hiPSC_SLC6ebs 194 bp overlap

GATA4 6 datasets

ChIP BJ1-hTERT GSE92491.GATA4.BJ1-hTERT 274 bp overlap

ChIP DE DE-GATA4-1 399 bp overlap

ChIP DE DE-GATA4-2 434 bp overlap

ChIP Hep-G2 GSE135714.GATA4.Hep-G2 183 bp overlap

ChIP pancreatic-progenitor GSE117136.GATA4.pancreatic-progenitor 434 bp overlap

ChIP pancreatic-progenitor_PP1 GSE104840.GATA4.pancreatic-progenitor_PP1 272 bp overlap

GATA6 3 datasets

ChIP DE DE-GATA6-1 282 bp overlap

ChIP DE DE-GATA6-2 434 bp overlap

ChIP pancreatic-progenitor GSE117136.GATA6.pancreatic-progenitor 317 bp overlap

GLIS1 2 datasets

ChIP HEK293 ENCFF299RSE 345 bp overlap

ChIP HEK293 ENCSR482BBZ.GLIS1.HEK293 258 bp overlap

HDAC2 1 dataset

ChIP RH4_Entinostat-6H GSE116344.HDAC2.RH4_Entinostat-6H 196 bp overlap

HDAC3 1 dataset

ChIP RH4_DMSO-6H GSE116344.HDAC3.RH4_DMSO-6H 234 bp overlap

KDM4C 1 dataset

ChIP KYSE-150 GSE53938.KDM4C.KYSE-150 159 bp overlap

KMT2A 2 datasets

ChIP HEK293T_N-term_C104 GSE90762.KMT2A.HEK293T_N-term_C104 167 bp overlap

ChIP HEK293T_N-term_C49 GSE90762.KMT2A.HEK293T_N-term_C49 269 bp overlap

MAZ 2 datasets

ChIP HEK293 GSE76494.MAZ.HEK293 158 bp overlap

ChIP IMR-90 ENCSR000EFF.MAZ.IMR-90 140 bp overlap

MED12 1 dataset

ChIP leiomyoma_PT967 GSE128230.MED12.leiomyoma_PT967 56 bp overlap

MTA2 1 dataset

ChIP RH4 GSE155861.MTA2.RH4 343 bp overlap

MYOD1 4 datasets

ChIP RD_shSNAI2 GSE137168.MYOD1.RD_shSNAI2 197 bp overlap

ChIP myoblast GSE50413.MYOD1.myoblast 136 bp overlap

ChIP rhabdomyosarcoma GSE50413.MYOD1.rhabdomyosarcoma 118 bp overlap

ChIP rhabdomyosarcoma GSE50413.MYOD1.rhabdomyosarcoma 122 bp overlap

MYOG 1 dataset

ChIP RH4_Entinostat-6H GSE116344.MYOG.RH4_Entinostat-6H 173 bp overlap

NR3C1 1 dataset

ChIP MDA-MB-361 GSE152203.NR3C1.MDA-MB-361 148 bp overlap

OSR2 1 dataset

ChIP HEK293 ENCSR324LTM.OSR2.HEK293 384 bp overlap

PATZ1 2 datasets

ChIP HEK293 ENCFF016MNJ 387 bp overlap

ChIP HEK293 ENCSR966ULI.PATZ1.HEK293 304 bp overlap

PAX3-FOXO1 1 dataset

ChIP RH4 GSE140115.PAX3-FOXO1.RH4 141 bp overlap

PDX1 1 dataset

ChIP hESC GSE58685.PDX1.hESC 207 bp overlap

PRDM10 1 dataset

ChIP HEK293 ENCFF145WQQ 367 bp overlap

RELA 1 dataset

ChIP KB GSE52469.RELA.KB 103 bp overlap

RNF2 2 datasets

ChIP K-562 ENCSR820GND.RNF2.K-562 245 bp overlap

ChIP K-562 ENCSR076YPO.RNF2.K-562 132 bp overlap

RUNX1 1 dataset

ChIP VCaP_DHT24H GSE58428.RUNX1.VCaP_DHT24H 434 bp overlap

SMAD2 1 dataset

ChIP endoderm GSE29422.SMAD2.endoderm 178 bp overlap

SMAD2-3 1 dataset

ChIP HUES-8_DE GSE109524.SMAD2-3.HUES-8_DE 397 bp overlap

SMAD4 1 dataset

ChIP endoderm GSE29422.SMAD4.endoderm 137 bp overlap

SMARCA4 2 datasets

ChIP NPC_siSOX GSE122631.SMARCA4.NPC_siSOX 228 bp overlap

ChIP endometrial-epithelial-cells_KO GSE106660.SMARCA4.endometrial-epithelial-cells_KO 341 bp overlap

SMARCC1 1 dataset

ChIP SK-N-MC GSE94275.SMARCC1.SK-N-MC 172 bp overlap

SOX2 1 dataset

ChIP HNSC GSE69479.SOX2.HNSC 219 bp overlap

TBP 1 dataset

ChIP hiPSC_WTb_RNase-neg GSE128135.TBP.hiPSC_WTb_RNase-neg 71 bp overlap

TCF12 1 dataset

ChIP Kasumi-1 GSE23730.TCF12.Kasumi-1 77 bp overlap

TEAD1 1 dataset

ChIP HEK293_siE1A GSE130135.TEAD1.HEK293_siE1A 114 bp overlap

TFAP2B 1 dataset

ChIP SK-N-SH ENCFF869XXQ 219 bp overlap

TFAP2C 2 datasets

ChIP UCLA1-hESCs_TFAP2C--_1d_TFAP2C_Induc GSE101074.TFAP2C.UCLA1-hESCs_TFAP2C--_1d_TFAP2C_Induc 245 bp overlap

ChIP UCLA1-hESCs_TFAP2C--_2d_TFAP2C_Induc GSE101074.TFAP2C.UCLA1-hESCs_TFAP2C--_2d_TFAP2C_Induc 295 bp overlap

WT1 1 dataset

ChIP HEK293 ENCSR966PJJ.WT1.HEK293 383 bp overlap

YY1 1 dataset

ChIP Hep-G2_RBM25-KD GSE120104.YY1.Hep-G2_RBM25-KD 300 bp overlap

ZBTB17 1 dataset

ChIP HEK293 ENCFF865LIO 283 bp overlap

ZBTB42 1 dataset

ChIP HEK293 GSE76494.ZBTB42.HEK293 381 bp overlap

ZBTB6 1 dataset

ChIP HEK293 GSE76494.ZBTB6.HEK293 193 bp overlap

ZBTB7A 1 dataset

ChIP VCaP_FBS GSE123089.ZBTB7A.VCaP_FBS 156 bp overlap

ZFHX2 1 dataset

ChIP HEK293 ENCFF167TUA 434 bp overlap

ZNF28 1 dataset

ChIP HEK293T GSE78099.ZNF28.HEK293T 225 bp overlap

ZNF316 2 datasets

ChIP K-562 ENCSR200JYP.ZNF316.K-562 175 bp overlap

ChIP K562 ENCFF281INV 72 bp overlap

ZNF572 1 dataset

ChIP Hep-G2 ENCSR663CTC.ZNF572.Hep-G2 136 bp overlap

ZNF574 1 dataset

ChIP HEK293 GSE76494.ZNF574.HEK293 198 bp overlap

ZNF600 1 dataset

ChIP HEK293 ENCFF785JSX 434 bp overlap

ZNF629 1 dataset

ChIP HEK293 ENCSR351NON.ZNF629.HEK293 228 bp overlap

ZNF639 1 dataset

ChIP HEK293 ENCSR080CST.ZNF639.HEK293 424 bp overlap

ZNF671 1 dataset

ChIP HEK293T GSE78099.ZNF671.HEK293T 346 bp overlap

ZNF770 1 dataset

ChIP HEK293 GSE76494.ZNF770.HEK293 148 bp overlap

ZXDB 1 dataset

ChIP HEK293 ENCSR559IOZ.ZXDB.HEK293 345 bp overlap