chr21 : 40,902,938 – 40,903,695
757 bp 113 TFs 2 linked genes
This 757 bp open chromatin element is linked to DSCAM and BACE2 and is bound by 113 transcription factors.
Linked Genes
2 genes
Gene↕ Expression Dist. to TSS↑ Distance↕ Link type↕
DSCAM 56.1 kb Distal Multiome
BACE2 264.6 kb Distal Multiome
Chromatin Accessibility

Genome Browser

Genomic view centred on this element. Tracks include ATAC-seq accessibility, RNA-seq expression, TF binding peaks, and element-to-gene loop arcs across the ESC → DE time course.

View limited to ±500 kb around this element.
For the full data, please see the UCSC track linked below.
chr21:40,897,938 – 40,908,695
This element Other elements Gene links ATAC-seq RNA-seq

Transcription factors with ChIP-seq peak overlap or TOBIAS motif footprint evidence at this element.

TF Binding
113 transcription factors
Source
Cell type
ARNT::HIF1A 1 dataset
Motif DE_48h DE_48h-ARNTHIF1A_MA0259.2 5 bp overlap
ATF4 2 datasets
Motif DE_48h DE_48h-ATF4_MA0833.3 10 bp overlap
Motif DE_60h DE_60h-ATF4_MA0833.3 10 bp overlap
BARX1 2 datasets
Motif DE_48h DE_48h-BARX1_MA0875.2 6 bp overlap
Motif DE_60h DE_60h-BARX1_MA0875.2 6 bp overlap
BRD4 1 dataset
ChIP HEK293_sgNT GSE129407.BRD4.HEK293_sgNT 293 bp overlap
BSX 2 datasets
Motif DE_48h DE_48h-BSX_MA0876.2 6 bp overlap
Motif DE_60h DE_60h-BSX_MA0876.2 6 bp overlap
CEBPG 2 datasets
Motif DE_48h DE_48h-CEBPG_MA1636.2 10 bp overlap
Motif DE_60h DE_60h-CEBPG_MA1636.2 10 bp overlap
Cebpa 1 dataset
ChIP BLaER1 ENCFF274GAT 524 bp overlap
Crx 1 dataset
Motif DE_72h DE_72h-Crx_MA0467.3 6 bp overlap
DLX1 2 datasets
Motif DE_48h DE_48h-DLX1_MA0879.3 6 bp overlap
Motif DE_60h DE_60h-DLX1_MA0879.3 6 bp overlap
DLX6 2 datasets
Motif DE_48h DE_48h-DLX6_MA0882.2 6 bp overlap
Motif DE_60h DE_60h-DLX6_MA0882.2 6 bp overlap
DUX4 4 datasets
Motif DE_48h DE_48h-DUX4_MA0468.1 11 bp overlap
Motif DE_48h DE_48h-DUX4_MA0468.1 11 bp overlap
Motif DE_60h DE_60h-DUX4_MA0468.1 11 bp overlap
ChIP WA01 GSE94322.DUX4.WA01 227 bp overlap
DUXA 2 datasets
Motif DE_48h DE_48h-DUXA_MA0884.2 13 bp overlap
Motif DE_60h DE_60h-DUXA_MA0884.2 13 bp overlap
Dlx3 2 datasets
Motif DE_48h DE_48h-Dlx3_MA0880.2 6 bp overlap
Motif DE_60h DE_60h-Dlx3_MA0880.2 6 bp overlap
Dlx4 2 datasets
Motif DE_48h DE_48h-Dlx4_MA0881.2 6 bp overlap
Motif DE_60h DE_60h-Dlx4_MA0881.2 6 bp overlap
Dmbx1 1 dataset
Motif DE_48h DE_48h-Dmbx1_MA0883.2 10 bp overlap
Dux 2 datasets
Motif DE_48h DE_48h-Dux_MA0611.3 11 bp overlap
Motif DE_60h DE_60h-Dux_MA0611.3 11 bp overlap
E2F7 1 dataset
Motif DE_48h DE_48h-E2F7_MA0758.1 14 bp overlap
EGR2 1 dataset
ChIP HEK293 ENCFF336LFH 357 bp overlap
EOMES 1 dataset
ChIP hESC GSE26097.EOMES.hESC 292 bp overlap
EZH2 1 dataset
ChIP THP-1 GSE135024.EZH2.THP-1 540 bp overlap
FEZF2 3 datasets
Motif DE_48h DE_48h-FEZF2_MA2341.1 8 bp overlap
Motif DE_60h DE_60h-FEZF2_MA2341.1 8 bp overlap
Motif DE_72h DE_72h-FEZF2_MA2341.1 8 bp overlap
FOS 2 datasets
Motif DE_48h DE_48h-FOS_MA0476.2 8 bp overlap
Motif DE_60h DE_60h-FOS_MA0476.2 8 bp overlap
FOSL1::JUND 2 datasets
Motif DE_48h DE_48h-FOSL1JUND_MA1142.2 8 bp overlap
Motif DE_60h DE_60h-FOSL1JUND_MA1142.2 8 bp overlap
FOXA2 2 datasets
ChIP DE DE-FOXA2-1 483 bp overlap
ChIP DE DE-FOXA2-2 504 bp overlap
FOXO1::ELF1 2 datasets
Motif DE_60h DE_60h-FOXO1ELF1_MA1953.2 13 bp overlap
Motif DE_72h DE_72h-FOXO1ELF1_MA1953.2 13 bp overlap
FOXP2 2 datasets
Motif DE_60h DE_60h-FOXP2_MA0593.2 9 bp overlap
Motif DE_72h DE_72h-FOXP2_MA0593.2 9 bp overlap
Foxl2 2 datasets
Motif DE_60h DE_60h-Foxl2_MA1607.2 10 bp overlap
Motif DE_72h DE_72h-Foxl2_MA1607.2 10 bp overlap
GATA4 5 datasets
ChIP DE DE-GATA4-1 602 bp overlap
ChIP DE DE-GATA4-2 609 bp overlap
Motif DE_48h DE_48h-GATA4_MA0482.3 8 bp overlap
Motif DE_72h DE_72h-GATA4_MA0482.3 8 bp overlap
ChIP foregut GSE117136.GATA4.foregut 467 bp overlap
GATA5 2 datasets
Motif DE_48h DE_48h-GATA5_MA0766.3 8 bp overlap
Motif DE_72h DE_72h-GATA5_MA0766.3 8 bp overlap
GATA6 10 datasets
ChIP DE DE-GATA6-1 664 bp overlap
ChIP DE DE-GATA6-2 636 bp overlap
ChIP DE_D1 S09-DE-d1-GATA6-exp1 528 bp overlap
ChIP DE_D1 S14-DE-d1-GATA6-exp1 563 bp overlap
ChIP DE_D1 S41-DE-d1-GATA6-exp2 490 bp overlap
ChIP DE_D2 S55-DE-d2-GATA6-exp2 609 bp overlap
ChIP HUES-8_DE_JNKi GSE109524.GATA6.HUES-8_DE_JNKi 597 bp overlap
ChIP HUES-8_DE_ctrl GSE109524.GATA6.HUES-8_DE_ctrl 477 bp overlap
ChIP endoderm_KO GSE117136.GATA6.endoderm_KO 465 bp overlap
ChIP foregut GSE117136.GATA6.foregut 477 bp overlap
GBX2 2 datasets
Motif DE_48h DE_48h-GBX2_MA0890.2 6 bp overlap
Motif DE_60h DE_60h-GBX2_MA0890.2 6 bp overlap
GLIS1 2 datasets
ChIP HEK293 ENCFF299RSE 183 bp overlap
ChIP HEK293 ENCSR482BBZ.GLIS1.HEK293 342 bp overlap
GLIS2 2 datasets
Motif DE_48h DE_48h-GLIS2_MA0736.1 14 bp overlap
Motif DE_60h DE_60h-GLIS2_MA0736.1 14 bp overlap
GLIS3 2 datasets
Motif DE_48h DE_48h-GLIS3_MA0737.1 14 bp overlap
Motif DE_60h DE_60h-GLIS3_MA0737.1 14 bp overlap
GSC 1 dataset
Motif DE_72h DE_72h-GSC_MA0648.2 6 bp overlap
GSC2 1 dataset
Motif DE_72h DE_72h-GSC2_MA0891.2 6 bp overlap
Gfi1B 1 dataset
Motif DE_48h DE_48h-Gfi1B_MA0483.2 10 bp overlap
HAND2 1 dataset
Motif DE_48h DE_48h-HAND2_MA1638.2 6 bp overlap
HESX1 2 datasets
Motif DE_48h DE_48h-HESX1_MA0894.2 6 bp overlap
Motif DE_60h DE_60h-HESX1_MA0894.2 6 bp overlap
HOXA7 2 datasets
Motif DE_48h DE_48h-HOXA7_MA1498.3 6 bp overlap
Motif DE_60h DE_60h-HOXA7_MA1498.3 6 bp overlap
JUN 3 datasets
ChIP DE_D2 S02-DE-d2-JUN-exp1 289 bp overlap
ChIP DE_D2 S54-DE-d2-JUN-exp2 291 bp overlap
ChIP MCF-7_DMSO GSE157385.JUN.MCF-7_DMSO 384 bp overlap
Jun 2 datasets
Motif DE_48h DE_48h-Jun_MA0489.3 8 bp overlap
Motif DE_60h DE_60h-Jun_MA0489.3 8 bp overlap
LBX2 2 datasets
Motif DE_48h DE_48h-LBX2_MA0699.2 6 bp overlap
Motif DE_60h DE_60h-LBX2_MA0699.2 6 bp overlap
LHX2 2 datasets
Motif DE_48h DE_48h-LHX2_MA0700.3 6 bp overlap
Motif DE_60h DE_60h-LHX2_MA0700.3 6 bp overlap
MEIS1 1 dataset
Motif DE_48h DE_48h-MEIS1_MA0498.3 5 bp overlap
MGA::EVX1 2 datasets
Motif DE_48h DE_48h-MGAEVX1_MA1960.2 11 bp overlap
Motif DE_60h DE_60h-MGAEVX1_MA1960.2 11 bp overlap
MSANTD3 2 datasets
Motif DE_60h DE_60h-MSANTD3_MA1523.2 7 bp overlap
Motif DE_72h DE_72h-MSANTD3_MA1523.2 7 bp overlap
MSX1 2 datasets
Motif DE_48h DE_48h-MSX1_MA0666.3 6 bp overlap
Motif DE_60h DE_60h-MSX1_MA0666.3 6 bp overlap
MSX2 2 datasets
Motif DE_48h DE_48h-MSX2_MA0708.3 6 bp overlap
Motif DE_60h DE_60h-MSX2_MA0708.3 6 bp overlap
MXI1 2 datasets
Motif DE_48h DE_48h-MXI1_MA1108.3 6 bp overlap
Motif DE_72h DE_72h-MXI1_MA1108.3 6 bp overlap
MZF1 1 dataset
Motif DE_48h DE_48h-MZF1_MA0056.3 8 bp overlap
Msx3 2 datasets
Motif DE_48h DE_48h-Msx3_MA0709.2 6 bp overlap
Motif DE_60h DE_60h-Msx3_MA0709.2 6 bp overlap
NEUROG2 1 dataset
Motif DE_48h DE_48h-NEUROG2_MA1642.2 7 bp overlap
NFATC3 2 datasets
Motif DE_48h DE_48h-NFATC3_MA0625.3 6 bp overlap
Motif DE_72h DE_72h-NFATC3_MA0625.3 6 bp overlap
NFATC4 2 datasets
Motif DE_48h DE_48h-NFATC4_MA1525.3 9 bp overlap
Motif DE_72h DE_72h-NFATC4_MA1525.3 9 bp overlap
NFIB 1 dataset
Motif DE_72h DE_72h-NFIB_MA1643.2 17 bp overlap
NFIC 1 dataset
Motif DE_72h DE_72h-NFIC_MA1527.2 15 bp overlap
NKX2-2 1 dataset
Motif DE_48h DE_48h-NKX2-2_MA1645.2 8 bp overlap
NKX2-4 3 datasets
Motif DE_48h DE_48h-NKX2-4_MA2003.2 8 bp overlap
Motif DE_60h DE_60h-NKX2-4_MA2003.2 8 bp overlap
Motif DE_72h DE_72h-NKX2-4_MA2003.2 8 bp overlap
NKX2-8 3 datasets
Motif DE_48h DE_48h-NKX2-8_MA0673.2 8 bp overlap
Motif DE_60h DE_60h-NKX2-8_MA0673.2 8 bp overlap
Motif DE_72h DE_72h-NKX2-8_MA0673.2 8 bp overlap
Nfatc1 2 datasets
Motif DE_48h DE_48h-Nfatc1_MA0624.3 6 bp overlap
Motif DE_72h DE_72h-Nfatc1_MA0624.3 6 bp overlap
Nkx2-1 3 datasets
Motif DE_48h DE_48h-Nkx2-1_MA1994.2 7 bp overlap
Motif DE_60h DE_60h-Nkx2-1_MA1994.2 7 bp overlap
Motif DE_72h DE_72h-Nkx2-1_MA1994.2 7 bp overlap
Nobox 2 datasets
Motif DE_48h DE_48h-Nobox_MA0125.2 6 bp overlap
Motif DE_60h DE_60h-Nobox_MA0125.2 6 bp overlap
Nr2F6 2 datasets
Motif DE_48h DE_48h-Nr2F6_MA0728.1 15 bp overlap
Motif DE_60h DE_60h-Nr2F6_MA0728.1 15 bp overlap
OTX1 1 dataset
Motif DE_72h DE_72h-OTX1_MA0711.2 6 bp overlap
OTX2 1 dataset
Motif DE_72h DE_72h-OTX2_MA0712.3 7 bp overlap
PGR 1 dataset
ChIP T-47D_PROG GSE68355.PGR.T-47D_PROG 147 bp overlap
PHOX2A 2 datasets
Motif DE_48h DE_48h-PHOX2A_MA0713.1 11 bp overlap
Motif DE_60h DE_60h-PHOX2A_MA0713.1 11 bp overlap
PITX1 1 dataset
Motif DE_72h DE_72h-PITX1_MA0682.3 6 bp overlap
PITX2 1 dataset
Motif DE_72h DE_72h-PITX2_MA1547.2 8 bp overlap
PITX3 1 dataset
Motif DE_72h DE_72h-PITX3_MA0714.2 6 bp overlap
PRDM9 3 datasets
Motif DE_48h DE_48h-PRDM9_MA1723.2 20 bp overlap
Motif DE_60h DE_60h-PRDM9_MA1723.2 20 bp overlap
Motif DE_72h DE_72h-PRDM9_MA1723.2 20 bp overlap
PROP1 2 datasets
Motif DE_48h DE_48h-PROP1_MA0715.1 11 bp overlap
Motif DE_60h DE_60h-PROP1_MA0715.1 11 bp overlap
Pax7 2 datasets
Motif DE_48h DE_48h-Pax7_MA0680.3 10 bp overlap
Motif DE_60h DE_60h-Pax7_MA0680.3 10 bp overlap
Ptf1A 1 dataset
Motif DE_48h DE_48h-Ptf1A_MA1618.2 9 bp overlap
RARA 1 dataset
Motif DE_48h DE_48h-RARA_MA0729.1 18 bp overlap
RAX 2 datasets
Motif DE_48h DE_48h-RAX_MA0718.2 6 bp overlap
Motif DE_60h DE_60h-RAX_MA0718.2 6 bp overlap
RHOXF1 1 dataset
Motif DE_72h DE_72h-RHOXF1_MA0719.2 6 bp overlap
SMAD2 1 dataset
ChIP endoderm GSE29422.SMAD2.endoderm 179 bp overlap
SMAD2-3 3 datasets
ChIP HUES-8_DE GSE109524.SMAD2-3.HUES-8_DE 543 bp overlap
ChIP HUES-8_DE_JNKi GSE109524.SMAD2-3.HUES-8_DE_JNKi 432 bp overlap
ChIP HUES-8_DE_ctrl GSE109524.SMAD2-3.HUES-8_DE_ctrl 301 bp overlap
SMAD2_3 5 datasets
ChIP DE_D1 S07-DE-d1-SMAD2_3-exp1 268 bp overlap
ChIP DE_D1 S12-DE-d1-SMAD2_3-exp1 417 bp overlap
ChIP DE_D1 S39-DE-d1-SMAD2_3-exp2 385 bp overlap
ChIP DE_D2 S01-DE-d2-SMAD2_3-exp1 505 bp overlap
ChIP DE_D2 S53-DE-d2-SMAD2_3-exp2 522 bp overlap
SOX15 3 datasets
Motif DE_48h DE_48h-SOX15_MA1152.2 7 bp overlap
Motif DE_60h DE_60h-SOX15_MA1152.2 7 bp overlap
Motif DE_72h DE_72h-SOX15_MA1152.2 7 bp overlap
SOX17 1 dataset
ChIP DE_D2 DED2-SOX17_Batch_II 689 bp overlap
SOX17_M 1 dataset
ChIP DE_D2 DED2-SOX17-M_Batch_II 757 bp overlap
SP5 7 datasets
Motif DE_48h DE_48h-SP5_MA1965.2 6 bp overlap
Motif DE_48h DE_48h-SP5_MA1965.2 6 bp overlap
Motif DE_48h DE_48h-SP5_MA1965.2 6 bp overlap
Motif DE_60h DE_60h-SP5_MA1965.2 6 bp overlap
Motif DE_60h DE_60h-SP5_MA1965.2 6 bp overlap
Motif DE_60h DE_60h-SP5_MA1965.2 6 bp overlap
Motif DE_72h DE_72h-SP5_MA1965.2 6 bp overlap
Sox6 3 datasets
Motif DE_48h DE_48h-Sox6_MA0515.1 10 bp overlap
Motif DE_60h DE_60h-Sox6_MA0515.1 10 bp overlap
Motif DE_72h DE_72h-Sox6_MA0515.1 10 bp overlap
Sox7 3 datasets
Motif DE_48h DE_48h-Sox7_MA2095.1 10 bp overlap
Motif DE_60h DE_60h-Sox7_MA2095.1 10 bp overlap
Motif DE_72h DE_72h-Sox7_MA2095.1 10 bp overlap
TBX18 3 datasets
Motif DE_48h DE_48h-TBX18_MA1565.2 9 bp overlap
Motif DE_60h DE_60h-TBX18_MA1565.2 9 bp overlap
Motif DE_72h DE_72h-TBX18_MA1565.2 9 bp overlap
TFAP4 2 datasets
Motif DE_48h DE_48h-TFAP4_MA1570.1 10 bp overlap
Motif DE_72h DE_72h-TFAP4_MA1570.1 10 bp overlap
TWIST1 1 dataset
Motif DE_48h DE_48h-TWIST1_MA1123.3 8 bp overlap
USF1 2 datasets
Motif DE_48h DE_48h-USF1_MA0093.4 10 bp overlap
Motif DE_72h DE_72h-USF1_MA0093.4 10 bp overlap
Wt1 4 datasets
Motif DE_48h DE_48h-Wt1_MA1627.2 10 bp overlap
Motif DE_48h DE_48h-Wt1_MA1627.2 10 bp overlap
Motif DE_60h DE_60h-Wt1_MA1627.2 10 bp overlap
Motif DE_60h DE_60h-Wt1_MA1627.2 10 bp overlap
ZBTB18 2 datasets
Motif DE_48h DE_48h-ZBTB18_MA0698.2 11 bp overlap
Motif DE_60h DE_60h-ZBTB18_MA0698.2 11 bp overlap
ZBTB26 2 datasets
Motif DE_48h DE_48h-ZBTB26_MA1579.2 8 bp overlap
Motif DE_60h DE_60h-ZBTB26_MA1579.2 8 bp overlap
ZBTB6 3 datasets
Motif DE_48h DE_48h-ZBTB6_MA1581.2 9 bp overlap
Motif DE_60h DE_60h-ZBTB6_MA1581.2 9 bp overlap
Motif DE_72h DE_72h-ZBTB6_MA1581.2 9 bp overlap
ZFHX2 1 dataset
ChIP HEK293 ENCFF167TUA 411 bp overlap
ZFP14 2 datasets
Motif DE_48h DE_48h-ZFP14_MA1972.1 15 bp overlap
Motif DE_60h DE_60h-ZFP14_MA1972.1 15 bp overlap
ZFP42 1 dataset
Motif DE_48h DE_48h-ZFP42_MA1651.2 13 bp overlap
ZFX 1 dataset
ChIP MCF-7 GSE102616.ZFX.MCF-7 439 bp overlap
ZIC1 2 datasets
Motif DE_60h DE_60h-ZIC1_MA0696.1 14 bp overlap
Motif DE_72h DE_72h-ZIC1_MA0696.1 14 bp overlap
ZIC4 2 datasets
Motif DE_48h DE_48h-ZIC4_MA0751.2 14 bp overlap
Motif DE_60h DE_60h-ZIC4_MA0751.2 14 bp overlap
ZIC5 2 datasets
Motif DE_48h DE_48h-ZIC5_MA1584.2 15 bp overlap
Motif DE_60h DE_60h-ZIC5_MA1584.2 15 bp overlap
ZNF135 6 datasets
Motif DE_48h DE_48h-ZNF135_MA1587.1 14 bp overlap
Motif DE_48h DE_48h-ZNF135_MA1587.1 14 bp overlap
Motif DE_60h DE_60h-ZNF135_MA1587.1 14 bp overlap
Motif DE_60h DE_60h-ZNF135_MA1587.1 14 bp overlap
Motif DE_72h DE_72h-ZNF135_MA1587.1 14 bp overlap
Motif DE_72h DE_72h-ZNF135_MA1587.1 14 bp overlap
ZNF140 1 dataset
Motif DE_48h DE_48h-ZNF140_MA1589.2 19 bp overlap
ZNF143 3 datasets
Motif DE_48h DE_48h-ZNF143_MA0088.2 16 bp overlap
Motif DE_60h DE_60h-ZNF143_MA0088.2 16 bp overlap
ChIP MCF-7 GSE76454.ZNF143.MCF-7 85 bp overlap
ZNF257 3 datasets
Motif DE_48h DE_48h-ZNF257_MA1710.2 10 bp overlap
Motif DE_60h DE_60h-ZNF257_MA1710.2 10 bp overlap
Motif DE_72h DE_72h-ZNF257_MA1710.2 10 bp overlap
ZNF263 5 datasets
Motif DE_48h DE_48h-ZNF263_MA0528.3 7 bp overlap
Motif DE_48h DE_48h-ZNF263_MA0528.3 7 bp overlap
Motif DE_60h DE_60h-ZNF263_MA0528.3 7 bp overlap
Motif DE_60h DE_60h-ZNF263_MA0528.3 7 bp overlap
Motif DE_72h DE_72h-ZNF263_MA0528.3 7 bp overlap
ZNF460 3 datasets
Motif DE_48h DE_48h-ZNF460_MA1596.1 16 bp overlap
Motif DE_60h DE_60h-ZNF460_MA1596.1 16 bp overlap
Motif DE_72h DE_72h-ZNF460_MA1596.1 16 bp overlap
ZNF550 1 dataset
ChIP Hep-G2 ENCSR198BHH.ZNF550.Hep-G2 206 bp overlap
ZNF740 1 dataset
Motif DE_48h DE_48h-ZNF740_MA0753.3 10 bp overlap
ZNF76 2 datasets
Motif DE_48h DE_48h-ZNF76_MA1716.2 17 bp overlap
Motif DE_60h DE_60h-ZNF76_MA1716.2 17 bp overlap
ZNF770 3 datasets
Motif DE_48h DE_48h-ZNF770_MA2099.1 8 bp overlap
Motif DE_60h DE_60h-ZNF770_MA2099.1 8 bp overlap
Motif DE_72h DE_72h-ZNF770_MA2099.1 8 bp overlap
ZNF85 1 dataset
Motif DE_48h DE_48h-ZNF85_MA1720.2 12 bp overlap
Huangfu Lab · Publications · Resources · Contact