chr21 : 45,977,133 – 45,977,741
608 bp 72 TFs 3 linked genes
This 608 bp open chromatin element is linked to ENSG00000289224, ENSG00000274248, and COL6A1 and is bound by 72 transcription factors.
Linked Genes
3 genes
Distance
Gene↕ Expression Dist. to TSS↑ Distance↕ Link type↕
ENSG00000289224 at TSS At TSS Proximity
ENSG00000274248 2.6 kb Proximal Proximity
COL6A1 4.0 kb Proximal Proximity
Chromatin Accessibility

Genome Browser

Genomic view centred on this element. Tracks include ATAC-seq accessibility, RNA-seq expression, TF binding peaks, and element-to-gene loop arcs across the ESC → DE time course.

View limited to ±500 kb around this element.
For the full data, please see the UCSC track linked below.
chr21:45,972,133 – 45,982,741
This element Other elements Gene links ATAC-seq RNA-seq

Transcription factors with ChIP-seq peak overlap or TOBIAS motif footprint evidence at this element.

TF Binding
72 transcription factors
Source
Cell type
AGO1 2 datasets
ChIP Hep-G2 ENCSR555ZMV.AGO1.Hep-G2 183 bp overlap
ChIP Hep-G2 GSE120104.AGO1.Hep-G2 183 bp overlap
ARID2 1 dataset
ChIP Aska-SS_shSSX GSE108025.ARID2.Aska-SS_shSSX 117 bp overlap
ASH2L 1 dataset
ChIP WA01 ENCSR850KIP.ASH2L.WA01 312 bp overlap
ATRX 1 dataset
ChIP metastatic-neuroblastoma_SKNMM GSE100148.ATRX.metastatic-neuroblastoma_SKNMM 271 bp overlap
BCOR 4 datasets
ChIP WA01 GSE104690.BCOR.WA01 212 bp overlap
ChIP WA01 GSE104690.BCOR.WA01 266 bp overlap
ChIP WA01_RNF2-R GSE104690.BCOR.WA01_RNF2-R 608 bp overlap
ChIP WA01_RNF2-R_Doxycyclin GSE104690.BCOR.WA01_RNF2-R_Doxycyclin 520 bp overlap
BRD1 1 dataset
ChIP HUES-64 GSE104059.BRD1.HUES-64 297 bp overlap
BRD4 16 datasets
ChIP 402-91 GSE111253.BRD4.402-91 321 bp overlap
ChIP BE2C GSE80151.BRD4.BE2C 326 bp overlap
ChIP CLL_patient2_4h_CpG_BET GSE109411.BRD4.CLL_patient2_4h_CpG_BET 193 bp overlap
ChIP Kelly_resistant GSE103030.BRD4.Kelly_resistant 356 bp overlap
ChIP Kelly_resistant_JQ1 GSE103030.BRD4.Kelly_resistant_JQ1 208 bp overlap
ChIP Kelly_sensitive GSE103030.BRD4.Kelly_sensitive 87 bp overlap
ChIP Kelly_sensitive GSE103030.BRD4.Kelly_sensitive 406 bp overlap
ChIP SK-N-BE2-C GSE80151.BRD4.SK-N-BE2-C 326 bp overlap
ChIP SK-N-BE2-C_Naive-veh GSE107706.BRD4.SK-N-BE2-C_Naive-veh 259 bp overlap
ChIP SK-N-BE2-C_Resistant-veh GSE107706.BRD4.SK-N-BE2-C_Resistant-veh 99 bp overlap
ChIP SK-N-BE2-C_Resistant-veh GSE107706.BRD4.SK-N-BE2-C_Resistant-veh 381 bp overlap
ChIP SUM1315_DMSO GSE63581.BRD4.SUM1315_DMSO 257 bp overlap
ChIP SUM159PT_scramble GSE131097.BRD4.SUM159PT_scramble 576 bp overlap
ChIP retina_AB1-FW15 GSE86981.BRD4.retina_AB1-FW15 331 bp overlap
ChIP retina_AB1-FW20 GSE86981.BRD4.retina_AB1-FW20 268 bp overlap
ChIP retina_AB1-FW23 GSE86981.BRD4.retina_AB1-FW23 260 bp overlap
CDK8 1 dataset
ChIP myometrium_PT916 GSE128230.CDK8.myometrium_PT916 94 bp overlap
CHD7 1 dataset
ChIP WA01 ENCSR000AVA.CHD7.WA01 132 bp overlap
CTBP2 2 datasets
ChIP H1 ENCFF329MAX 355 bp overlap
ChIP WA01 ENCSR000EUO.CTBP2.WA01 413 bp overlap
CTCF 5 datasets
ChIP Kelly_sensitive GSE103030.CTCF.Kelly_sensitive 123 bp overlap
ChIP astrocyte of the spinal cord ENCFF213GKL 261 bp overlap
ChIP astrocyte_spinal_cord ENCSR000DSU.CTCF.astrocyte_spinal_cord 159 bp overlap
ChIP fibroblast_SKIN_LEG ENCSR000DPG.CTCF.fibroblast_SKIN_LEG 90 bp overlap
ChIP uterus ENCSR392SFJ.CTCF.uterus 150 bp overlap
EP300 3 datasets
ChIP Ishikawa ENCSR000BUE.EP300.Ishikawa 224 bp overlap
ChIP SK-N-SH ENCSR000EHV.EP300.SK-N-SH 134 bp overlap
ChIP WA01 ENCSR000AUQ.EP300.WA01 146 bp overlap
ESR1 1 dataset
ChIP Ishikawa_DMSO_D538G_clone3 GSE132426.ESR1.Ishikawa_DMSO_D538G_clone3 203 bp overlap
ETS1 4 datasets
ChIP cardiomyocyte_D0 GSE129986.ETS1.cardiomyocyte_D0 608 bp overlap
ChIP cardiomyocyte_D2 GSE129986.ETS1.cardiomyocyte_D2 422 bp overlap
ChIP cardiomyocyte_D5 GSE129986.ETS1.cardiomyocyte_D5 301 bp overlap
ChIP cardiomyocyte_D9 GSE129986.ETS1.cardiomyocyte_D9 135 bp overlap
ETV1 2 datasets
ChIP GIST-T1 GSE106624.ETV1.GIST-T1 297 bp overlap
ChIP GIST-T1 GSE80443.ETV1.GIST-T1 203 bp overlap
GATA6 1 dataset
ChIP HUES-8_DE_ctrl GSE109524.GATA6.HUES-8_DE_ctrl 259 bp overlap
GLIS1 2 datasets
ChIP HEK293 ENCFF299RSE 460 bp overlap
ChIP HEK293 ENCSR482BBZ.GLIS1.HEK293 411 bp overlap
GLIS2 4 datasets
ChIP HCT-116_5FU GSE125927.GLIS2.HCT-116_5FU 293 bp overlap
ChIP HCT-116_DMSO GSE125927.GLIS2.HCT-116_DMSO 266 bp overlap
ChIP HEK293 ENCFF446EIF 430 bp overlap
ChIP HEK293 ENCSR535DIA.GLIS2.HEK293 273 bp overlap
GLIS3 1 dataset
ChIP H9_plus GSE109562.GLIS3.H9_plus 608 bp overlap
HAND2 3 datasets
ChIP CLB-Ga GSE90683.HAND2.CLB-Ga 351 bp overlap
ChIP Kelly GSE94822.HAND2.Kelly 340 bp overlap
ChIP SK-N-BE2-C GSE94822.HAND2.SK-N-BE2-C 225 bp overlap
HDAC2 1 dataset
ChIP WA01 ENCSR000AVB.HDAC2.WA01 160 bp overlap
HNRNPK 1 dataset
ChIP Hep-G2 GSE120104.HNRNPK.Hep-G2 189 bp overlap
IKZF3 2 datasets
ChIP HEK293 ENCSR304AMN.IKZF3.HEK293 213 bp overlap
ChIP pre-B-cell GSE107886.IKZF3.pre-B-cell 233 bp overlap
JARID2 1 dataset
ChIP MRC-5_IPS25_MEG3 GSE48515.JARID2.MRC-5_IPS25_MEG3 203 bp overlap
JUN 1 dataset
ChIP DE_D2 S02-DE-d2-JUN-exp1 260 bp overlap
KDM4A 2 datasets
ChIP H1 ENCFF078LED 373 bp overlap
ChIP H1 ENCFF078LED 474 bp overlap
KLF1 2 datasets
ChIP HEK293 ENCSR859BMR.KLF1.HEK293 242 bp overlap
ChIP HEK293 GSE76494.KLF1.HEK293 187 bp overlap
KLF17 2 datasets
ChIP HEK293 ENCFF658MHR 380 bp overlap
ChIP HEK293 ENCSR065WUF.KLF17.HEK293 386 bp overlap
KLF9 1 dataset
ChIP GBM1A GSE62211.KLF9.GBM1A 160 bp overlap
MAZ 2 datasets
ChIP HEK293 ENCSR290SSQ.MAZ.HEK293 211 bp overlap
ChIP IMR-90 ENCSR000EFF.MAZ.IMR-90 104 bp overlap
MED1 1 dataset
ChIP myoblast GSE60026.MED1.myoblast 268 bp overlap
MYCN 6 datasets
ChIP BE2C GSE80151.MYCN.BE2C 235 bp overlap
ChIP Kelly GSE94782.MYCN.Kelly 376 bp overlap
ChIP Kelly_sensitive GSE115249.MYCN.Kelly_sensitive 213 bp overlap
ChIP NB-1643 GSE138295.MYCN.NB-1643 283 bp overlap
ChIP NB-1643 GSE94782.MYCN.NB-1643 192 bp overlap
ChIP SK-N-BE2-C GSE80151.MYCN.SK-N-BE2-C 235 bp overlap
NANOG 1 dataset
ChIP HUES-8 GSE109524.NANOG.HUES-8 344 bp overlap
NFKB1 2 datasets
ChIP HEK293T GSE129618.NFKB1.HEK293T 266 bp overlap
ChIP HEK293T_2KR GSE129618.NFKB1.HEK293T_2KR 319 bp overlap
OSR2 3 datasets
ChIP HEK293 ENCFF875BDB 319 bp overlap
ChIP HEK293 ENCSR324LTM.OSR2.HEK293 256 bp overlap
ChIP HEK293 GSE76494.OSR2.HEK293 147 bp overlap
PATZ1 1 dataset
ChIP HEK293 ENCSR966ULI.PATZ1.HEK293 247 bp overlap
PCBP1 2 datasets
ChIP Hep-G2 ENCSR872EVQ.PCBP1.Hep-G2 97 bp overlap
ChIP Hep-G2 GSE120104.PCBP1.Hep-G2 97 bp overlap
PCGF1 2 datasets
ChIP WA01 GSE104690.PCGF1.WA01 99 bp overlap
ChIP WA01 GSE104690.PCGF1.WA01 393 bp overlap
PHIP 1 dataset
ChIP HCT-116_MLL1-KO__ab833 GSE101646.PHIP.HCT-116_MLL1-KO__ab833 196 bp overlap
POLR2A 4 datasets
ChIP sigmoid colon ENCFF725QFT 281 bp overlap
ChIP sigmoid colon ENCFF748YVT 359 bp overlap
ChIP uterus ENCFF208ADI 343 bp overlap
ChIP vagina ENCFF384GAB 362 bp overlap
POU5F1 3 datasets
ChIP DE_D1 DED1-OCT4_Batch_II 608 bp overlap
ChIP HUES-8 GSE109524.POU5F1.HUES-8 281 bp overlap
ChIP SKM-1 GSE93706.POU5F1.SKM-1 259 bp overlap
POU5F1_M 1 dataset
ChIP DE_D1 DED1-OCT4-M_Batch_II 608 bp overlap
RBBP5 2 datasets
ChIP WA01 ENCSR000AQC.RBBP5.WA01 70 bp overlap
ChIP WA01 ENCSR000AQC.RBBP5.WA01 330 bp overlap
RELA 1 dataset
ChIP 786-O GSE86092.RELA.786-O 70 bp overlap
SAP30 1 dataset
ChIP WA01 ENCSR000ATR.SAP30.WA01 284 bp overlap
SIN3A 1 dataset
ChIP WA01 ENCSR000EBO.SIN3A.WA01 290 bp overlap
SIRT6 1 dataset
ChIP SK-MEL-239_L-C-B GSE102813.SIRT6.SK-MEL-239_L-C-B 365 bp overlap
SMAD2-3 2 datasets
ChIP HUES-8_DE_JNKi GSE109524.SMAD2-3.HUES-8_DE_JNKi 344 bp overlap
ChIP HUES-8_DE_ctrl GSE109524.SMAD2-3.HUES-8_DE_ctrl 396 bp overlap
SMAD2_3 4 datasets
ChIP DE_D1 S07-DE-d1-SMAD2_3-exp1 277 bp overlap
ChIP DE_D1 S12-DE-d1-SMAD2_3-exp1 252 bp overlap
ChIP DE_D1 S39-DE-d1-SMAD2_3-exp2 348 bp overlap
ChIP DE_D2 S01-DE-d2-SMAD2_3-exp1 383 bp overlap
SMARCA4 2 datasets
ChIP HS-SY-2_HA-tagged GSE108926.SMARCA4.HS-SY-2_HA-tagged 455 bp overlap
ChIP SYO-1 GSE108025.SMARCA4.SYO-1 100 bp overlap
SMARCC1 6 datasets
ChIP HS-SY-2 GSE108025.SMARCC1.HS-SY-2 608 bp overlap
ChIP SYO-1_shCt GSE139053.SMARCC1.SYO-1_shCt 420 bp overlap
ChIP SYO-1_shRING1A-B GSE139053.SMARCC1.SYO-1_shRING1A-B 143 bp overlap
ChIP SYO-1_shRING1A-B GSE139053.SMARCC1.SYO-1_shRING1A-B 227 bp overlap
ChIP hiPSC GSE124903.SMARCC1.hiPSC 537 bp overlap
ChIP hiPSC_WT GSE124903.SMARCC1.hiPSC_WT 191 bp overlap
SREBP2 1 dataset
ChIP HCC70 GSE126380.SREBP2.HCC70 116 bp overlap
SS18 4 datasets
ChIP Aska-SS GSE108025.SS18.Aska-SS 105 bp overlap
ChIP Aska-SS_BAF47KO1 GSE108025.SS18.Aska-SS_BAF47KO1 608 bp overlap
ChIP SYO-1_shCt GSE139053.SS18.SYO-1_shCt 608 bp overlap
ChIP SYO-1_shRING1A-B GSE139053.SS18.SYO-1_shRING1A-B 91 bp overlap
STAT3 5 datasets
ChIP MDA-MB-157_EtOH GSE85579.STAT3.MDA-MB-157_EtOH 275 bp overlap
ChIP T-47D_JC4751 GSE126004.STAT3.T-47D_JC4751 220 bp overlap
ChIP T-47D_JC5054 GSE126004.STAT3.T-47D_JC5054 158 bp overlap
ChIP T-47D_JC5056 GSE126004.STAT3.T-47D_JC5056 299 bp overlap
ChIP T-47D_JC5062 GSE126004.STAT3.T-47D_JC5062 198 bp overlap
SUZ12 2 datasets
ChIP WA01 ENCSR000ATS.SUZ12.WA01 65 bp overlap
ChIP WA01 ENCSR000ATS.SUZ12.WA01 170 bp overlap
T 1 dataset
ChIP H9_ENDODERM GSE60606.T.H9_ENDODERM 185 bp overlap
TBX2 1 dataset
ChIP Kelly GSE94822.TBX2.Kelly 141 bp overlap
TCF12 2 datasets
ChIP Ishikawa ENCSR000BUV.TCF12.Ishikawa 220 bp overlap
ChIP WA01 ENCSR000BIT.TCF12.WA01 88 bp overlap
TFAP2B 1 dataset
ChIP SK-N-SH ENCFF869XXQ 364 bp overlap
TFAP2C 3 datasets
ChIP UCLA1-hESCs_TFAP2C--_1d_TFAP2C_Induc GSE101074.TFAP2C.UCLA1-hESCs_TFAP2C--_1d_TFAP2C_Induc 53 bp overlap
ChIP UCLA1-hESCs_TFAP2C--_1d_TFAP2C_Induc GSE101074.TFAP2C.UCLA1-hESCs_TFAP2C--_1d_TFAP2C_Induc 329 bp overlap
ChIP UCLA1-hESCs_TFAP2C--_2d_TFAP2C_Induc GSE101074.TFAP2C.UCLA1-hESCs_TFAP2C--_2d_TFAP2C_Induc 518 bp overlap
TRIM28 2 datasets
ChIP WIBR3_NAIVE GSE84382.TRIM28.WIBR3_NAIVE 81 bp overlap
ChIP hESC GSE115387.TRIM28.hESC 209 bp overlap
TWIST1 2 datasets
ChIP BE2C GSE80151.TWIST1.BE2C 429 bp overlap
ChIP SK-N-BE2-C GSE80151.TWIST1.SK-N-BE2-C 429 bp overlap
ZFX 1 dataset
ChIP HEK293T_FLAG GSE145160.ZFX.HEK293T_FLAG 320 bp overlap
ZIC2 1 dataset
ChIP HEK293 ENCFF033NQQ 314 bp overlap
ZNF143 2 datasets
ChIP WA01 ENCSR000EBW.ZNF143.WA01 108 bp overlap
ChIP WA01 ENCSR000EBW.ZNF143.WA01 255 bp overlap
ZNF148 2 datasets
ChIP K-562 GSE121133.ZNF148.K-562 256 bp overlap
ChIP K-562 GSE121133.ZNF148.K-562 66 bp overlap
ZNF263 6 datasets
ChIP HEK293T GSE78099.ZNF263.HEK293T 115 bp overlap
ChIP HEK293T GSE78099.ZNF263.HEK293T 222 bp overlap
ChIP Hep-G2 ENCSR313MMD.ZNF263.Hep-G2 111 bp overlap
ChIP K562 ENCFF640RNA 298 bp overlap
ChIP WTC11 ENCFF893RTM 368 bp overlap
ChIP WTC11 ENCFF893RTM 437 bp overlap
ZNF281 1 dataset
ChIP K-562 GSE121133.ZNF281.K-562 202 bp overlap
ZNF341 3 datasets
ChIP HEK293 ENCFF944VMC 395 bp overlap
ChIP HEK293 ENCSR185FOY.ZNF341.HEK293 282 bp overlap
ChIP HEK293 GSE76494.ZNF341.HEK293 141 bp overlap
ZNF423 1 dataset
ChIP WTC11 ENCFF574PBR 221 bp overlap
ZNF444 2 datasets
ChIP MCF-7 ENCFF602QFR 320 bp overlap
ChIP MCF-7 ENCSR038XIA.ZNF444.MCF-7 304 bp overlap
ZNF468 1 dataset
ChIP HEK293T GSE78099.ZNF468.HEK293T 429 bp overlap
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