chr2 : 40,458,304 – 40,458,980
676 bp 104 TFs 2 linked genes
This 676 bp open chromatin element is linked to SLC8A1 and ENSG00000288992 and is bound by 104 transcription factors.
Linked Genes
2 genes
Gene↕ Expression Dist. to TSS↑ Distance↕ Link type↕
SLC8A1 6.2 kb Proximal Proximity
ENSG00000288992 6.6 kb Proximal Proximity
Chromatin Accessibility

Genome Browser

Genomic view centred on this element. Tracks include ATAC-seq accessibility, RNA-seq expression, TF binding peaks, and element-to-gene loop arcs across the ESC → DE time course.

View limited to ±500 kb around this element.
For the full data, please see the UCSC track linked below.
chr2:40,453,304 – 40,463,980
This element Other elements Gene links ATAC-seq RNA-seq

Transcription factors with ChIP-seq peak overlap or TOBIAS motif footprint evidence at this element.

TF Binding
104 transcription factors
Source
Cell type
AFF4 1 dataset
ChIP HeLa_EGF GSE40632.AFF4.HeLa_EGF 147 bp overlap
ARID1A 1 dataset
ChIP NGP GSE134626.ARID1A.NGP 251 bp overlap
ASCL1 5 datasets
Motif DE_60h DE_60h-ASCL1_MA1631.2 9 bp overlap
Motif DE_72h DE_72h-ASCL1_MA1631.2 9 bp overlap
ChIP NCI-H2107 GSE69394.ASCL1.NCI-H2107 123 bp overlap
ChIP NCI-H889 GSE69394.ASCL1.NCI-H889 148 bp overlap
ChIP SCLC_ASCLP GSE61197.ASCL1.SCLC_ASCLP 161 bp overlap
BNC2 2 datasets
ChIP SK-N-SH ENCFF174EMC 425 bp overlap
ChIP SK-N-SH_all-trans-retinoic-acid_6-uM_48-hour ENCSR754GYI.BNC2.SK-N-SH_all-trans-retinoic-acid_6-uM_48-hour 222 bp overlap
BRD4 7 datasets
ChIP Hs-352-Sk_PAX3-FOXO1-vector GSE83725.BRD4.Hs-352-Sk_PAX3-FOXO1-vector 364 bp overlap
ChIP Kelly_resistant GSE103030.BRD4.Kelly_resistant 539 bp overlap
ChIP Kelly_resistant_JQ1 GSE103030.BRD4.Kelly_resistant_JQ1 396 bp overlap
ChIP Kelly_sensitive GSE103030.BRD4.Kelly_sensitive 504 bp overlap
ChIP RH4_shCHD4 GSE140115.BRD4.RH4_shCHD4 220 bp overlap
ChIP SK-N-BE2-C_Naive-veh GSE107706.BRD4.SK-N-BE2-C_Naive-veh 510 bp overlap
ChIP SK-N-BE2-C_Resistant-veh GSE107706.BRD4.SK-N-BE2-C_Resistant-veh 498 bp overlap
CASZ1 2 datasets
ChIP rhabdomyosarcoma_DOX GSE126142.CASZ1.rhabdomyosarcoma_DOX 395 bp overlap
ChIP rhabdomyosarcoma_Trametinib GSE126143.CASZ1.rhabdomyosarcoma_Trametinib 493 bp overlap
CEBPB 1 dataset
ChIP HeLa-S3 ENCFF722WEG 265 bp overlap
CHD2 2 datasets
ChIP SK-N-SH ENCFF669KMB 361 bp overlap
ChIP SK-N-SH ENCSR274SLQ.CHD2.SK-N-SH 247 bp overlap
CHD4 1 dataset
ChIP SCMC GSE155861.CHD4.SCMC 676 bp overlap
CTCF 3 datasets
ChIP Kelly_resistant GSE103030.CTCF.Kelly_resistant 135 bp overlap
ChIP Kelly_sensitive GSE103030.CTCF.Kelly_sensitive 107 bp overlap
ChIP islet ERP004003.CTCF.islet 188 bp overlap
CTCFL 1 dataset
ChIP Kelly_resistant GSE103030.CTCFL.Kelly_resistant 117 bp overlap
EBF3_P177L 1 dataset
ChIP SK-N-SH GSE90682.EBF3_P177L.SK-N-SH 321 bp overlap
EP300 2 datasets
ChIP SK-N-SH ENCFF829RWA 377 bp overlap
ChIP SK-N-SH ENCSR000EHV.EP300.SK-N-SH 339 bp overlap
ESR1 1 dataset
ChIP breast-cancer_3487 GSE126004.ESR1.breast-cancer_3487 385 bp overlap
ESRRG 1 dataset
ChIP cardiomyocyte GSE113760.ESRRG.cardiomyocyte 386 bp overlap
ETS1 1 dataset
ChIP cardiomyocyte_D9 GSE129986.ETS1.cardiomyocyte_D9 211 bp overlap
EZH2 3 datasets
ChIP A673 ENCFF790MVL 574 bp overlap
ChIP A673 ENCFF790MVL 382 bp overlap
ChIP RH30_DMSO GSE85169.EZH2.RH30_DMSO 388 bp overlap
FIGLA 2 datasets
Motif DE_60h DE_60h-FIGLA_MA0820.2 6 bp overlap
Motif DE_72h DE_72h-FIGLA_MA0820.2 6 bp overlap
FOS 1 dataset
ChIP HeLa-S3 ENCSR000EZE.FOS.HeLa-S3 195 bp overlap
FOXA1 1 dataset
ChIP breast-cancer_3487 GSE126004.FOXA1.breast-cancer_3487 298 bp overlap
FOXA2 2 datasets
ChIP DE DE-FOXA2-1 504 bp overlap
ChIP DE DE-FOXA2-2 450 bp overlap
FOXJ3 1 dataset
ChIP SK-N-SH ENCFF124KVL 441 bp overlap
FOXL2 1 dataset
ChIP HGrC1_C134W-TGF GSE138496.FOXL2.HGrC1_C134W-TGF 189 bp overlap
FOXN3 1 dataset
Motif DE_60h DE_60h-FOXN3_MA1489.1 8 bp overlap
Foxl2 1 dataset
Motif DE_60h DE_60h-Foxl2_MA1607.2 10 bp overlap
GATA2 4 datasets
ChIP SH-SY5Y ENCFF485YIB 202 bp overlap
ChIP SH-SY5Y ENCSR000EYB.GATA2.SH-SY5Y 508 bp overlap
ChIP SK-N-SH ENCFF764OZD 157 bp overlap
ChIP SK-N-SH ENCSR706VOO.GATA2.SK-N-SH 500 bp overlap
GATA3 3 datasets
ChIP Kelly GSE65664.GATA3.Kelly 511 bp overlap
ChIP SH-SY5Y ENCSR000EXZ.GATA3.SH-SY5Y 329 bp overlap
ChIP SK-N-BE2-C GSE94822.GATA3.SK-N-BE2-C 433 bp overlap
GATA4 8 datasets
ChIP DE DE-GATA4-1 485 bp overlap
ChIP DE DE-GATA4-2 580 bp overlap
ChIP G296S_4 GSE85628.GATA4.G296S_4 284 bp overlap
ChIP Hep-G2 GSE135714.GATA4.Hep-G2 465 bp overlap
ChIP cardiomyocyte_5 GSE85628.GATA4.cardiomyocyte_5 314 bp overlap
ChIP foregut GSE117136.GATA4.foregut 453 bp overlap
ChIP pancreatic-progenitor GSE117136.GATA4.pancreatic-progenitor 460 bp overlap
ChIP pancreatic-progenitor_PP1 GSE104840.GATA4.pancreatic-progenitor_PP1 476 bp overlap
GATA6 8 datasets
ChIP DE DE-GATA6-1 487 bp overlap
ChIP DE DE-GATA6-2 625 bp overlap
ChIP DE_D2 S55-DE-d2-GATA6-exp2 494 bp overlap
ChIP endoderm_KO GSE117136.GATA6.endoderm_KO 394 bp overlap
ChIP foregut GSE117136.GATA6.foregut 417 bp overlap
ChIP pancreatic-progenitor GSE117136.GATA6.pancreatic-progenitor 352 bp overlap
ChIP pancreatic-progenitor_KO GSE117136.GATA6.pancreatic-progenitor_KO 391 bp overlap
ChIP pancreatic-progenitor_PP1 GSE104840.GATA6.pancreatic-progenitor_PP1 455 bp overlap
HAND2 3 datasets
ChIP CLB-Ga GSE90683.HAND2.CLB-Ga 485 bp overlap
ChIP Kelly GSE94822.HAND2.Kelly 289 bp overlap
ChIP SK-N-BE2-C GSE94822.HAND2.SK-N-BE2-C 599 bp overlap
HDAC2 2 datasets
ChIP RH4_DMSO-6H GSE116344.HDAC2.RH4_DMSO-6H 303 bp overlap
ChIP RH4_Entinostat-6H GSE116344.HDAC2.RH4_Entinostat-6H 316 bp overlap
HDAC3 1 dataset
ChIP RH4_DMSO-6H GSE116344.HDAC3.RH4_DMSO-6H 237 bp overlap
ISL1 1 dataset
ChIP SK-N-BE2-C GSE94822.ISL1.SK-N-BE2-C 600 bp overlap
KDM1A 2 datasets
ChIP SH-SY5Y_B0_SHLSD18A GSE58258.KDM1A.SH-SY5Y_B0_SHLSD18A 218 bp overlap
ChIP SH-SY5Y_B3 GSE58258.KDM1A.SH-SY5Y_B3 385 bp overlap
MAF::NFE2 2 datasets
Motif DE_60h DE_60h-MAFNFE2_MA0501.2 11 bp overlap
Motif DE_72h DE_72h-MAFNFE2_MA0501.2 11 bp overlap
MAFB 1 dataset
ChIP islet ERP004003.MAFB.islet 343 bp overlap
MAFF 1 dataset
ChIP HeLa-S3 ENCSR140DSL.MAFF.HeLa-S3 102 bp overlap
MAFG::NFE2L1 2 datasets
Motif DE_60h DE_60h-MAFGNFE2L1_MA0089.3 11 bp overlap
Motif DE_72h DE_72h-MAFGNFE2L1_MA0089.3 11 bp overlap
MAFK 2 datasets
ChIP Hep-G2 ENCSR000EDZ.MAFK.Hep-G2 80 bp overlap
ChIP IMR-90 ENCFF336DHZ 152 bp overlap
MAX 1 dataset
ChIP HeLa-S3 ENCSR000EZF.MAX.HeLa-S3 260 bp overlap
MED1 1 dataset
ChIP G296S_4 GSE85628.MED1.G296S_4 126 bp overlap
MEIS1 5 datasets
Motif DE_60h DE_60h-MEIS1_MA0498.3 5 bp overlap
Motif DE_60h DE_60h-MEIS1_MA0498.3 5 bp overlap
Motif DE_60h DE_60h-MEIS1_MA0498.3 5 bp overlap
Motif DE_72h DE_72h-MEIS1_MA0498.3 5 bp overlap
Motif DE_72h DE_72h-MEIS1_MA0498.3 5 bp overlap
MEIS3 2 datasets
Motif DE_60h DE_60h-MEIS3_MA0775.2 7 bp overlap
Motif DE_72h DE_72h-MEIS3_MA0775.2 7 bp overlap
MTA2 1 dataset
ChIP RH4 GSE155861.MTA2.RH4 410 bp overlap
MXI1 2 datasets
ChIP SK-N-SH ENCFF746HVJ 491 bp overlap
ChIP SK-N-SH ENCSR000EIA.MXI1.SK-N-SH 246 bp overlap
MYC 1 dataset
ChIP HeLa-S3 ENCSR000EZD.MYC.HeLa-S3 158 bp overlap
MYCN 6 datasets
ChIP COG-N-415 GSE138295.MYCN.COG-N-415 402 bp overlap
ChIP Kelly GSE94822.MYCN.Kelly 521 bp overlap
ChIP Kelly_sensitive GSE115249.MYCN.Kelly_sensitive 356 bp overlap
ChIP LA-N-5 GSE138295.MYCN.LA-N-5 328 bp overlap
ChIP RH4 GSE83726.MYCN.RH4 245 bp overlap
ChIP SK-N-BE2-C GSE94822.MYCN.SK-N-BE2-C 359 bp overlap
MYF5 1 dataset
ChIP Rh18 GSE84628.MYF5.Rh18 258 bp overlap
MYOD1 7 datasets
ChIP RD GSE137168.MYOD1.RD 375 bp overlap
ChIP RD_shSNAI2 GSE137168.MYOD1.RD_shSNAI2 365 bp overlap
ChIP RH30_DMSO GSE85169.MYOD1.RH30_DMSO 579 bp overlap
ChIP RH4 GSE83726.MYOD1.RH4 282 bp overlap
ChIP SMS-CTR GSE137168.MYOD1.SMS-CTR 419 bp overlap
ChIP myoblast GSE50413.MYOD1.myoblast 238 bp overlap
ChIP rhabdomyosarcoma GSE50413.MYOD1.rhabdomyosarcoma 232 bp overlap
MYOG 1 dataset
ChIP RH4_DMSO-6H GSE116344.MYOG.RH4_DMSO-6H 176 bp overlap
Msgn1 1 dataset
Motif DE_60h DE_60h-Msgn1_MA1524.3 10 bp overlap
NFYA 1 dataset
ChIP HeLa-S3 ENCFF016YWF 365 bp overlap
NKX3-1 1 dataset
ChIP islet ERP004003.NKX3-1.islet 327 bp overlap
NRF1 1 dataset
ChIP HeLa-S3 GSE108856.NRF1.HeLa-S3 402 bp overlap
Nfe2l2 2 datasets
Motif DE_60h DE_60h-Nfe2l2_MA0150.3 11 bp overlap
Motif DE_72h DE_72h-Nfe2l2_MA0150.3 11 bp overlap
PAX3-FOXO1 2 datasets
ChIP Hs-352-Sk_PAX3-FOXO1-vector GSE83725.PAX3-FOXO1.Hs-352-Sk_PAX3-FOXO1-vector 182 bp overlap
ChIP RH4 GSE140115.PAX3-FOXO1.RH4 194 bp overlap
PAX6 1 dataset
Motif DE_60h DE_60h-PAX6_MA0069.1 14 bp overlap
PDX1 1 dataset
ChIP hiPSC_derived_PPs GSE106949.PDX1.hiPSC_derived_PPs 162 bp overlap
PGR 2 datasets
Motif DE_60h DE_60h-PGR_MA2327.1 9 bp overlap
Motif DE_72h DE_72h-PGR_MA2327.1 9 bp overlap
PHOX2B 1 dataset
ChIP CLB-Ga GSE90683.PHOX2B.CLB-Ga 248 bp overlap
PITX3 1 dataset
ChIP SH-SY5Y GSE93275.PITX3.SH-SY5Y 528 bp overlap
POU4F2 1 dataset
ChIP HNPC_DIF GSE74814.POU4F2.HNPC_DIF 126 bp overlap
RAD21 1 dataset
ChIP SK-N-SH ENCFF747MAS 251 bp overlap
RBBP4 2 datasets
ChIP RH5 GSE155861.RBBP4.RH5 579 bp overlap
ChIP SCMC GSE155861.RBBP4.SCMC 630 bp overlap
RCOR1 2 datasets
ChIP SK-N-SH ENCFF518EXB 365 bp overlap
ChIP SK-N-SH ENCSR009TKN.RCOR1.SK-N-SH 408 bp overlap
RUNX1 1 dataset
ChIP SKH1 GSE87283.RUNX1.SKH1 189 bp overlap
SMAD2 1 dataset
ChIP endoderm GSE29422.SMAD2.endoderm 145 bp overlap
SMAD2-3 3 datasets
ChIP HGrC1_C134W-TGF GSE138496.SMAD2-3.HGrC1_C134W-TGF 162 bp overlap
ChIP HGrC1_WT-TGF GSE138496.SMAD2-3.HGrC1_WT-TGF 172 bp overlap
ChIP HUES-8_DE GSE109524.SMAD2-3.HUES-8_DE 676 bp overlap
SMAD2_3 1 dataset
ChIP DE_D2 S01-DE-d2-SMAD2_3-exp1 331 bp overlap
SMAD4 1 dataset
ChIP endoderm GSE29422.SMAD4.endoderm 170 bp overlap
SMARCA4 5 datasets
ChIP A-549_AG15688 GSE132290.SMARCA4.A-549_AG15688 234 bp overlap
ChIP NGP GSE134626.SMARCA4.NGP 499 bp overlap
ChIP NGP_ARID1A-het GSE134626.SMARCA4.NGP_ARID1A-het 191 bp overlap
ChIP NGP_ARID1A-mut1 GSE134626.SMARCA4.NGP_ARID1A-mut1 188 bp overlap
ChIP NGP_ARID1A-mut2 GSE134626.SMARCA4.NGP_ARID1A-mut2 147 bp overlap
SMARCC1 1 dataset
ChIP Aska-SS GSE108025.SMARCC1.Aska-SS 218 bp overlap
SMC1A-B 1 dataset
ChIP Kelly_shLUC-res GSE115248.SMC1A-B.Kelly_shLUC-res 170 bp overlap
SNAI1 2 datasets
Motif DE_60h DE_60h-SNAI1_MA1558.2 7 bp overlap
Motif DE_72h DE_72h-SNAI1_MA1558.2 7 bp overlap
SNAI2 6 datasets
ChIP RD GSE137168.SNAI2.RD 259 bp overlap
ChIP SK-N-SH ENCFF449PID 337 bp overlap
ChIP SMS-CTR GSE137168.SNAI2.SMS-CTR 214 bp overlap
ChIP SMS-CTR_D48 GSE137168.SNAI2.SMS-CTR_D48 212 bp overlap
ChIP SMS-CTR_T48 GSE137168.SNAI2.SMS-CTR_T48 223 bp overlap
ChIP SMS-CTR_shSNAI2 GSE137168.SNAI2.SMS-CTR_shSNAI2 271 bp overlap
SOX10 1 dataset
Motif DE_60h DE_60h-SOX10_MA0442.3 6 bp overlap
SOX17_M 1 dataset
ChIP DE_D2 DED2-SOX17-M_Batch_II 330 bp overlap
SOX4 1 dataset
Motif DE_60h DE_60h-SOX4_MA0867.3 8 bp overlap
SS18 1 dataset
ChIP SYO-1_shRING1A-B GSE139053.SS18.SYO-1_shRING1A-B 420 bp overlap
SS18-SSX 1 dataset
ChIP fibroblast_78aa-SSX-Tail GSE139053.SS18-SSX.fibroblast_78aa-SSX-Tail 342 bp overlap
STAT1 1 dataset
ChIP HeLa-S3 ENCSR000EZK.STAT1.HeLa-S3 144 bp overlap
STAT3 1 dataset
ChIP breast-cancer_3487 GSE126004.STAT3.breast-cancer_3487 260 bp overlap
TAL1 1 dataset
ChIP PRIMA5 GSE33850.TAL1.PRIMA5 188 bp overlap
TBX2 2 datasets
ChIP Kelly GSE94822.TBX2.Kelly 413 bp overlap
ChIP SK-N-BE2-C GSE94822.TBX2.SK-N-BE2-C 358 bp overlap
TBX5 6 datasets
ChIP G296S GSE85628.TBX5.G296S 294 bp overlap
ChIP G296S_2 GSE85628.TBX5.G296S_2 294 bp overlap
ChIP G296S_4 GSE85628.TBX5.G296S_4 237 bp overlap
ChIP cardiomyocyte_5 GSE85628.TBX5.cardiomyocyte_5 357 bp overlap
ChIP cardiomyocyte_7 GSE85628.TBX5.cardiomyocyte_7 274 bp overlap
ChIP hiPSC GSE81585.TBX5.hiPSC 223 bp overlap
TCF12 2 datasets
Motif DE_60h DE_60h-TCF12_MA1648.2 7 bp overlap
Motif DE_72h DE_72h-TCF12_MA1648.2 7 bp overlap
TCF3 2 datasets
Motif DE_60h DE_60h-TCF3_MA0522.4 7 bp overlap
Motif DE_72h DE_72h-TCF3_MA0522.4 7 bp overlap
TCF4 4 datasets
Motif DE_60h DE_60h-TCF4_MA0830.3 8 bp overlap
Motif DE_72h DE_72h-TCF4_MA0830.3 8 bp overlap
ChIP GEN2-2 GSE76147.TCF4.GEN2-2 181 bp overlap
ChIP SH-SY5Y GSE96915.TCF4.SH-SY5Y 194 bp overlap
TEAD4 2 datasets
ChIP BE2C GSE84389.TEAD4.BE2C 377 bp overlap
ChIP SK-N-BE2 GSE84389.TEAD4.SK-N-BE2 377 bp overlap
TFAP2A 1 dataset
Motif DE_60h DE_60h-TFAP2A_MA0003.5 9 bp overlap
TFAP2B 2 datasets
Motif DE_60h DE_60h-TFAP2B_MA0812.2 9 bp overlap
ChIP SK-N-SH ENCFF869XXQ 441 bp overlap
TFAP2C 1 dataset
Motif DE_60h DE_60h-TFAP2C_MA0814.3 9 bp overlap
TFAP2E 1 dataset
Motif DE_60h DE_60h-TFAP2E_MA1569.2 9 bp overlap
TRIM28 2 datasets
ChIP HEK293 ENCSR618HNF.TRIM28.HEK293 261 bp overlap
ChIP U2OS ENCSR000EYC.TRIM28.U2OS 379 bp overlap
TSHZ2 2 datasets
ChIP SK-N-SH ENCFF182EBB 381 bp overlap
ChIP SK-N-SH_all-trans-retinoic-acid_6-uM_48-hour ENCSR282NLQ.TSHZ2.SK-N-SH_all-trans-retinoic-acid_6-uM_48-hour 196 bp overlap
TWIST1 2 datasets
ChIP BE2C GSE80151.TWIST1.BE2C 151 bp overlap
ChIP SK-N-BE2-C GSE80151.TWIST1.SK-N-BE2-C 151 bp overlap
YY1 2 datasets
ChIP Hep-G2_NC GSE120104.YY1.Hep-G2_NC 293 bp overlap
ChIP Hep-G2_RBM25-KD GSE120104.YY1.Hep-G2_RBM25-KD 250 bp overlap
ZEB1 3 datasets
Motif DE_60h DE_60h-ZEB1_MA0103.4 6 bp overlap
Motif DE_72h DE_72h-ZEB1_MA0103.4 6 bp overlap
ChIP neuron_bipolar_doxy_4d ENCSR418KUS.ZEB1.neuron_bipolar_doxy_4d 175 bp overlap
ZIC1 2 datasets
Motif DE_60h DE_60h-ZIC1_MA0696.1 14 bp overlap
Motif DE_72h DE_72h-ZIC1_MA0696.1 14 bp overlap
ZNF213 1 dataset
Motif DE_60h DE_60h-ZNF213_MA2121.1 12 bp overlap
ZNF324 1 dataset
Motif DE_60h DE_60h-ZNF324_MA1977.2 14 bp overlap
ZNF652 1 dataset
Motif DE_60h DE_60h-ZNF652_MA1657.2 9 bp overlap
ZNF768 1 dataset
Motif DE_60h DE_60h-ZNF768_MA1731.2 9 bp overlap
Zic2 4 datasets
Motif DE_60h DE_60h-Zic2_MA1629.2 9 bp overlap
Motif DE_60h DE_60h-Zic2_MA1629.2 9 bp overlap
Motif DE_72h DE_72h-Zic2_MA1629.2 9 bp overlap
Motif DE_72h DE_72h-Zic2_MA1629.2 9 bp overlap
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