chr3:156,628,812–156,629,757

chr3 : 156,628,812 – 156,629,757

945 bp 108 TFs 5 linked genes

This 945 bp open chromatin element is linked to 5 target genes and is bound by 108 transcription factors.

Linked Genes

5 genes

Gene	Expression	Dist. to TSS	Distance	Link type
TIPARP		45.2 kb	Distal	Multiome
SSR3		74.2 kb	Distal	Multiome
LINC00886		122.2 kb	Distal	Multiome
LEKR1		197.0 kb	Distal	Multiome
ENSG00000243176		545.9 kb	Distal	Multiome+HiCAR

Chromatin Accessibility

Genome Browser

Genomic view centred on this element. Tracks include ATAC-seq accessibility, RNA-seq expression, TF binding peaks, and element-to-gene loop arcs across the ESC → DE time course.

Transcription factors with ChIP-seq peak overlap or TOBIAS motif footprint evidence at this element.

TF Binding

108 transcription factors

ChIP LNCaP_R1881 GSE69043.AR.LNCaP_R1881 196 bp overlap

ARID1A 1 dataset

ChIP MCF-7_4-hydroxytamoxifen GSE123284.ARID1A.MCF-7_4-hydroxytamoxifen 343 bp overlap

BCL6B 2 datasets

Motif DE_48h DE_48h-BCL6B_MA0731.1 17 bp overlap

Motif DE_60h DE_60h-BCL6B_MA0731.1 17 bp overlap

BRD4 4 datasets

ChIP PC-3_GDC-R GSE137207.BRD4.PC-3_GDC-R 199 bp overlap

ChIP SUM159PT_100nMtrametinib300nMJQ1_24h GSE87418.BRD4.SUM159PT_100nMtrametinib300nMJQ1_24h 120 bp overlap

ChIP SUM159PT_100nMtrametinib_24h GSE87418.BRD4.SUM159PT_100nMtrametinib_24h 233 bp overlap

ChIP SUM159PT_shMYC_dox_48h GSE87418.BRD4.SUM159PT_shMYC_dox_48h 315 bp overlap

Bach1::Mafk 3 datasets

Motif DE_36h DE_36h-Bach1Mafk_MA0591.2 12 bp overlap

Motif DE_48h DE_48h-Bach1Mafk_MA0591.2 12 bp overlap

Motif DE_60h DE_60h-Bach1Mafk_MA0591.2 12 bp overlap

CEBPG 1 dataset

ChIP K562 ENCFF783ADE 62 bp overlap

CREBBP 2 datasets

ChIP PC-3 GSE147455.CREBBP.PC-3 241 bp overlap

ChIP PC-3_GDC-resist GSE147455.CREBBP.PC-3_GDC-resist 334 bp overlap

Motif DE_48h DE_48h-EBF1_MA0154.5 11 bp overlap

ChIP PDAC_SHCTR GSE64557.ELF3.PDAC_SHCTR 82 bp overlap

EOMES 1 dataset

ChIP hESC GSE26097.EOMES.hESC 245 bp overlap

EP300 3 datasets

ChIP PC-3 GSE147455.EP300.PC-3 179 bp overlap

ChIP upper lobe of left lung ENCFF024QBJ 261 bp overlap

ChIP upper lobe of left lung ENCFF024QBJ 257 bp overlap

ChIP MCF-7_D538G GSE148277.ESR1.MCF-7_D538G 222 bp overlap

ESR2 2 datasets

Motif DE_48h DE_48h-ESR2_MA0258.2 15 bp overlap

Motif DE_60h DE_60h-ESR2_MA0258.2 15 bp overlap

EWSR1-FLI1 2 datasets

Motif DE_48h DE_48h-EWSR1-FLI1_MA0149.1 18 bp overlap

Motif DE_60h DE_60h-EWSR1-FLI1_MA0149.1 18 bp overlap

Motif DE_48h DE_48h-Ebf4_MA2122.1 11 bp overlap

Elf5 2 datasets

Motif DE_48h DE_48h-Elf5_MA0136.4 8 bp overlap

Motif DE_60h DE_60h-Elf5_MA0136.4 8 bp overlap

FEZF2 2 datasets

Motif DE_48h DE_48h-FEZF2_MA2341.1 8 bp overlap

Motif DE_60h DE_60h-FEZF2_MA2341.1 8 bp overlap

FIGLA 3 datasets

Motif DE_48h DE_48h-FIGLA_MA0820.2 6 bp overlap

Motif DE_60h DE_60h-FIGLA_MA0820.2 6 bp overlap

Motif DE_60h DE_60h-FIGLA_MA0820.2 6 bp overlap

FOXA2 3 datasets

ChIP DE DE-FOXA2-1 751 bp overlap

ChIP DE DE-FOXA2-2 215 bp overlap

ChIP DE DE-FOXA2-2 495 bp overlap

GATA2 3 datasets

ChIP LNCaP GSE38391.GATA2.LNCaP 150 bp overlap

ChIP LNCaP GSE52725.GATA2.LNCaP 150 bp overlap

ChIP LNCaP_CSFCS GSE69043.GATA2.LNCaP_CSFCS 233 bp overlap

GATA3 6 datasets

ChIP Kelly GSE65664.GATA3.Kelly 161 bp overlap

ChIP MCF-7 ENCFF352QVM 481 bp overlap

ChIP MCF-7 ENCFF437NQS 93 bp overlap

ChIP MCF-7 GSE51274.GATA3.MCF-7 213 bp overlap

ChIP MCF-7_E2 GSE60270.GATA3.MCF-7_E2 146 bp overlap

ChIP T-47D GSE51274.GATA3.T-47D 284 bp overlap

GATA3_Nter 2 datasets

ChIP T-47D_CR3flp GSE99479.GATA3_Nter.T-47D_CR3flp 345 bp overlap

ChIP T-47D_flp-ctrl GSE99479.GATA3_Nter.T-47D_flp-ctrl 191 bp overlap

GATA4 5 datasets

ChIP DE DE-GATA4-1 767 bp overlap

ChIP DE DE-GATA4-2 945 bp overlap

ChIP YCC-3 GSE51705.GATA4.YCC-3 223 bp overlap

ChIP foregut GSE117136.GATA4.foregut 291 bp overlap

ChIP pancreatic-progenitor GSE117136.GATA4.pancreatic-progenitor 598 bp overlap

GATA6 13 datasets

ChIP Caco-2_PROLIF GSE23436.GATA6.Caco-2_PROLIF 146 bp overlap

ChIP DE DE-GATA6-1 783 bp overlap

ChIP DE DE-GATA6-2 882 bp overlap

ChIP DE_D1 S09-DE-d1-GATA6-exp1 599 bp overlap

ChIP DE_D1 S14-DE-d1-GATA6-exp1 794 bp overlap

ChIP DE_D1 S41-DE-d1-GATA6-exp2 663 bp overlap

ChIP DE_D2 S55-DE-d2-GATA6-exp2 829 bp overlap

ChIP HUES-8_DE_JNKi GSE109524.GATA6.HUES-8_DE_JNKi 820 bp overlap

ChIP HUES-8_DE_ctrl GSE109524.GATA6.HUES-8_DE_ctrl 671 bp overlap

ChIP HUG1N GSE51936.GATA6.HUG1N 160 bp overlap

ChIP YCC-3 GSE51705.GATA6.YCC-3 317 bp overlap

ChIP YCC-3 GSE51705.GATA6.YCC-3 199 bp overlap

ChIP endoderm_KO GSE117136.GATA6.endoderm_KO 723 bp overlap

GFI1 4 datasets

Motif DE_48h DE_48h-GFI1_MA0038.3 11 bp overlap

Motif DE_48h DE_48h-GFI1_MA0038.3 11 bp overlap

Motif DE_60h DE_60h-GFI1_MA0038.3 11 bp overlap

Motif DE_60h DE_60h-GFI1_MA0038.3 11 bp overlap

GFI1B 2 datasets

ChIP HEK293 ENCSR445PDR.GFI1B.HEK293 223 bp overlap

ChIP K-562 ENCSR509GDT.GFI1B.K-562 111 bp overlap

GLIS1 1 dataset

ChIP HEK293 ENCSR482BBZ.GLIS1.HEK293 448 bp overlap

GRHL2 3 datasets

Motif DE_48h DE_48h-GRHL2_MA1105.3 8 bp overlap

Motif DE_60h DE_60h-GRHL2_MA1105.3 8 bp overlap

ChIP MCF-7_E2_45min GSE109820.GRHL2.MCF-7_E2_45min 179 bp overlap

HDAC1 1 dataset

ChIP K-562 ENCSR387UWP.HDAC1.K-562 244 bp overlap

HDAC2 1 dataset

ChIP PC-3 GSE147455.HDAC2.PC-3 404 bp overlap

HNF4A 2 datasets

Motif DE_48h DE_48h-HNF4A_MA0114.5 9 bp overlap

Motif DE_60h DE_60h-HNF4A_MA0114.5 9 bp overlap

HNF4G 2 datasets

Motif DE_48h DE_48h-HNF4G_MA0484.3 9 bp overlap

Motif DE_60h DE_60h-HNF4G_MA0484.3 9 bp overlap

HOXB8 1 dataset

ChIP CFPAC-1_HOXB8-OE GSE119930.HOXB8.CFPAC-1_HOXB8-OE 276 bp overlap

HOXC13 2 datasets

Motif DE_48h DE_48h-HOXC13_MA0907.2 9 bp overlap

Motif DE_60h DE_60h-HOXC13_MA0907.2 9 bp overlap

ChIP MCF-7_hyperthermia-15min GSE137558.HSF1.MCF-7_hyperthermia-15min 201 bp overlap

Motif DE_48h DE_48h-Hic1_MA0739.2 8 bp overlap

IKZF2 2 datasets

Motif DE_48h DE_48h-IKZF2_MA2326.1 6 bp overlap

Motif DE_60h DE_60h-IKZF2_MA2326.1 6 bp overlap

ChIP SK-N-BE2-C GSE94822.ISL1.SK-N-BE2-C 233 bp overlap

Motif DE_60h DE_60h-Isl1_MA1608.2 7 bp overlap

KLF4 2 datasets

Motif DE_48h DE_48h-KLF4_MA0039.5 8 bp overlap

Motif DE_60h DE_60h-KLF4_MA0039.5 8 bp overlap

KLF5 2 datasets

Motif DE_48h DE_48h-KLF5_MA0599.1 10 bp overlap

Motif DE_60h DE_60h-KLF5_MA0599.1 10 bp overlap

Motif DE_36h DE_36h-MAF_MA1520.2 13 bp overlap

Motif DE_48h DE_48h-MAF_MA1520.2 13 bp overlap

Motif DE_60h DE_60h-MAF_MA1520.2 13 bp overlap

MAF::NFE2 3 datasets

Motif DE_36h DE_36h-MAFNFE2_MA0501.2 11 bp overlap

Motif DE_48h DE_48h-MAFNFE2_MA0501.2 11 bp overlap

Motif DE_60h DE_60h-MAFNFE2_MA0501.2 11 bp overlap

MAFA 3 datasets

Motif DE_36h DE_36h-MAFA_MA1521.2 13 bp overlap

Motif DE_48h DE_48h-MAFA_MA1521.2 13 bp overlap

Motif DE_60h DE_60h-MAFA_MA1521.2 13 bp overlap

MAFG::NFE2L1 3 datasets

Motif DE_36h DE_36h-MAFGNFE2L1_MA0089.3 11 bp overlap

Motif DE_48h DE_48h-MAFGNFE2L1_MA0089.3 11 bp overlap

Motif DE_60h DE_60h-MAFGNFE2L1_MA0089.3 11 bp overlap

MAFK 3 datasets

Motif DE_36h DE_36h-MAFK_MA0496.4 10 bp overlap

Motif DE_48h DE_48h-MAFK_MA0496.4 10 bp overlap

Motif DE_60h DE_60h-MAFK_MA0496.4 10 bp overlap

Motif DE_48h DE_48h-MSC_MA0665.1 10 bp overlap

Motif DE_60h DE_60h-MSC_MA0665.1 10 bp overlap

MYOD1 3 datasets

Motif DE_48h DE_48h-MYOD1_MA0499.3 9 bp overlap

Motif DE_60h DE_60h-MYOD1_MA0499.3 9 bp overlap

ChIP RH30_DMSO GSE85169.MYOD1.RH30_DMSO 354 bp overlap

MZF1 2 datasets

Motif DE_48h DE_48h-MZF1_MA0056.3 8 bp overlap

Motif DE_60h DE_60h-MZF1_MA0056.3 8 bp overlap

Mafg 3 datasets

Motif DE_36h DE_36h-Mafg_MA0659.4 12 bp overlap

Motif DE_48h DE_48h-Mafg_MA0659.4 12 bp overlap

Motif DE_60h DE_60h-Mafg_MA0659.4 12 bp overlap

NANOG 1 dataset

ChIP WA01_3IL ERP004238.NANOG.WA01_3IL 181 bp overlap

NEUROD1 1 dataset

ChIP D283-Med GSE92582.NEUROD1.D283-Med 60 bp overlap

NFE2 2 datasets

ChIP K-562 ENCSR000FCC.NFE2.K-562 150 bp overlap

ChIP K562 ENCFF047YKA 405 bp overlap

Motif DE_48h DE_48h-NFYB_MA0502.3 9 bp overlap

NKX2-1 1 dataset

ChIP NCI-H1819 GSE39998.NKX2-1.NCI-H1819 787 bp overlap

NR2F2 1 dataset

ChIP MCF-7 ENCSR000BUY.NR2F2.MCF-7 135 bp overlap

Nanog 2 datasets

Motif DE_48h DE_48h-Nanog_MA2339.1 7 bp overlap

Motif DE_60h DE_60h-Nanog_MA2339.1 7 bp overlap

Nfe2l2 3 datasets

Motif DE_36h DE_36h-Nfe2l2_MA0150.3 11 bp overlap

Motif DE_48h DE_48h-Nfe2l2_MA0150.3 11 bp overlap

Motif DE_60h DE_60h-Nfe2l2_MA0150.3 11 bp overlap

PHIP 2 datasets

ChIP HCT-116_MLL1-KO__ab833 GSE101646.PHIP.HCT-116_MLL1-KO__ab833 101 bp overlap

ChIP HCT-116_MLL1-KO__ab833 GSE101646.PHIP.HCT-116_MLL1-KO__ab833 358 bp overlap

POLR2A 1 dataset

ChIP stomach ENCFF820WZN 345 bp overlap

Prdm5 1 dataset

Motif DE_60h DE_60h-Prdm5_MA1999.2 11 bp overlap

Ptf1A 2 datasets

Motif DE_48h DE_48h-Ptf1A_MA1620.2 8 bp overlap

Motif DE_60h DE_60h-Ptf1A_MA1620.2 8 bp overlap

Motif DE_48h DE_48h-RARA_MA0730.1 17 bp overlap

RARA::RXRG 1 dataset

Motif DE_48h DE_48h-RARARXRG_MA1149.2 17 bp overlap

RBPJ 2 datasets

Motif DE_48h DE_48h-RBPJ_MA1116.2 6 bp overlap

Motif DE_60h DE_60h-RBPJ_MA1116.2 6 bp overlap

Motif DE_48h DE_48h-REL_MA0101.1 10 bp overlap

Motif DE_60h DE_60h-REL_MA0101.1 10 bp overlap

ChIP LNCaP_SICTR_TNFA GSE83860.RELA.LNCaP_SICTR_TNFA 277 bp overlap

RORA 4 datasets

Motif DE_48h DE_48h-RORA_MA0071.1 10 bp overlap

Motif DE_48h DE_48h-RORA_MA0072.2 11 bp overlap

Motif DE_60h DE_60h-RORA_MA0071.1 10 bp overlap

Motif DE_60h DE_60h-RORA_MA0072.2 11 bp overlap

RORB 2 datasets

Motif DE_48h DE_48h-RORB_MA1150.2 10 bp overlap

Motif DE_60h DE_60h-RORB_MA1150.2 10 bp overlap

RORC 2 datasets

Motif DE_48h DE_48h-RORC_MA1151.2 10 bp overlap

Motif DE_60h DE_60h-RORC_MA1151.2 10 bp overlap

RUNX1_mut 1 dataset

ChIP CD34 GSE111917.RUNX1_mut.CD34 254 bp overlap

Motif DE_48h DE_48h-Rarb_MA0858.1 17 bp overlap

SCRT1 2 datasets

Motif DE_48h DE_48h-SCRT1_MA0743.3 10 bp overlap

Motif DE_60h DE_60h-SCRT1_MA0743.3 10 bp overlap

SCRT2 3 datasets

Motif DE_48h DE_48h-SCRT2_MA0744.3 10 bp overlap

Motif DE_60h DE_60h-SCRT2_MA0744.3 10 bp overlap

ChIP HEK293 ENCFF711QQB 261 bp overlap

SMAD2-3 2 datasets

ChIP HUES-8_DE GSE109524.SMAD2-3.HUES-8_DE 638 bp overlap

ChIP HUES-8_DE_JNKi GSE109524.SMAD2-3.HUES-8_DE_JNKi 449 bp overlap

SMAD2_3 2 datasets

ChIP DE_D2 S01-DE-d2-SMAD2_3-exp1 341 bp overlap

ChIP DE_D2 S53-DE-d2-SMAD2_3-exp2 789 bp overlap

SMAD3 2 datasets

ChIP HCC1954 GSE104760.SMAD3.HCC1954 379 bp overlap

ChIP HCC1954_TGFb GSE104760.SMAD3.HCC1954_TGFb 209 bp overlap

SMARCA4 2 datasets

ChIP BIN-67_lentivirus-SMARCA4 GSE117734.SMARCA4.BIN-67_lentivirus-SMARCA4 55 bp overlap

ChIP endometrial-epithelial-cells_KO GSE106660.SMARCA4.endometrial-epithelial-cells_KO 316 bp overlap

SNAI2 2 datasets

Motif DE_48h DE_48h-SNAI2_MA0745.3 8 bp overlap

Motif DE_60h DE_60h-SNAI2_MA0745.3 8 bp overlap

SOX17 1 dataset

ChIP DE_D2 DED2-SOX17_Batch_II 256 bp overlap

SOX17_M 1 dataset

ChIP DE_D2 DED2-SOX17-M_Batch_II 720 bp overlap

ChIP HT29 GSE63629.SOX9.HT29 188 bp overlap

SPI1 6 datasets

ChIP CD34_FETAL GSE70660.SPI1.CD34_FETAL 171 bp overlap

ChIP CTV-1_FLAG_15perc GSE128835.SPI1.CTV-1_FLAG_15perc 251 bp overlap

ChIP DC_96h_donorM GSE128834.SPI1.DC_96h_donorM 166 bp overlap

ChIP GM12891 ENCSR000BIJ.SPI1.GM12891 128 bp overlap

ChIP K-562 GSE70482.SPI1.K-562 218 bp overlap

ChIP K-562 ENCSR000BGW.SPI1.K-562 100 bp overlap

STAT3 1 dataset

ChIP monocyte_IL10 GSE120943.STAT3.monocyte_IL10 142 bp overlap

STAT5B 1 dataset

ChIP CD8_H9 GSE64713.STAT5B.CD8_H9 234 bp overlap

ChIP H9_ENDODERM GSE60606.T.H9_ENDODERM 182 bp overlap

TBX5 2 datasets

ChIP cardiomyocyte GSE85628.TBX5.cardiomyocyte 475 bp overlap

ChIP cardiomyocyte_1 GSE85628.TBX5.cardiomyocyte_1 475 bp overlap

TEAD1 1 dataset

ChIP keratinocyte GSE138727.TEAD1.keratinocyte 59 bp overlap

TEAD4 1 dataset

ChIP PC-9_2DF_DMSO GSE131687.TEAD4.PC-9_2DF_DMSO 99 bp overlap

TRPS1 1 dataset

ChIP MCF-7 GSE133072.TRPS1.MCF-7 315 bp overlap

Tfcp2l1 1 dataset

Motif DE_48h DE_48h-Tfcp2l1_MA0145.2 14 bp overlap

VEZF1 3 datasets

Motif DE_36h DE_36h-VEZF1_MA1578.2 6 bp overlap

Motif DE_48h DE_48h-VEZF1_MA1578.2 6 bp overlap

Motif DE_60h DE_60h-VEZF1_MA1578.2 6 bp overlap

ChIP Hep-G2_NC GSE120104.YY1.Hep-G2_NC 234 bp overlap

ChIP Hep-G2_RBM25-KD GSE120104.YY1.Hep-G2_RBM25-KD 387 bp overlap

ZBTB20 1 dataset

ChIP HEK293 ENCSR460MBI.ZBTB20.HEK293 288 bp overlap

ZEB1 3 datasets

Motif DE_48h DE_48h-ZEB1_MA0103.4 6 bp overlap

Motif DE_60h DE_60h-ZEB1_MA0103.4 6 bp overlap

Motif DE_60h DE_60h-ZEB1_MA0103.4 6 bp overlap

ZFP64 2 datasets

ChIP HEK293 GSE76494.ZFP64.HEK293 241 bp overlap

ChIP Hep-G2 ENCSR487CPI.ZFP64.Hep-G2 158 bp overlap

ZIC1 2 datasets

Motif DE_48h DE_48h-ZIC1_MA0696.1 14 bp overlap

Motif DE_60h DE_60h-ZIC1_MA0696.1 14 bp overlap

ZIC4 2 datasets

Motif DE_48h DE_48h-ZIC4_MA0751.2 14 bp overlap

Motif DE_60h DE_60h-ZIC4_MA0751.2 14 bp overlap

ZKSCAN1 3 datasets

Motif DE_36h DE_36h-ZKSCAN1_MA1585.2 9 bp overlap

Motif DE_48h DE_48h-ZKSCAN1_MA1585.2 9 bp overlap

Motif DE_60h DE_60h-ZKSCAN1_MA1585.2 9 bp overlap

ZNF281 2 datasets

Motif DE_48h DE_48h-ZNF281_MA1630.3 10 bp overlap

Motif DE_60h DE_60h-ZNF281_MA1630.3 10 bp overlap

ZNF449 2 datasets

Motif DE_48h DE_48h-ZNF449_MA1656.2 10 bp overlap

Motif DE_60h DE_60h-ZNF449_MA1656.2 10 bp overlap

ZNF460 2 datasets

Motif DE_48h DE_48h-ZNF460_MA1596.1 16 bp overlap

Motif DE_60h DE_60h-ZNF460_MA1596.1 16 bp overlap

ZNF547 4 datasets

Motif DE_36h DE_36h-ZNF547_MA2334.1 13 bp overlap

Motif DE_48h DE_48h-ZNF547_MA2334.1 13 bp overlap

Motif DE_48h DE_48h-ZNF547_MA2334.1 13 bp overlap

Motif DE_60h DE_60h-ZNF547_MA2334.1 13 bp overlap

ZNF740 3 datasets

Motif DE_36h DE_36h-ZNF740_MA0753.3 10 bp overlap

Motif DE_48h DE_48h-ZNF740_MA0753.3 10 bp overlap

Motif DE_60h DE_60h-ZNF740_MA0753.3 10 bp overlap

ZNF768 3 datasets

Motif DE_36h DE_36h-ZNF768_MA1731.2 9 bp overlap

Motif DE_48h DE_48h-ZNF768_MA1731.2 9 bp overlap

Motif DE_60h DE_60h-ZNF768_MA1731.2 9 bp overlap

ZSCAN16 2 datasets

Motif DE_48h DE_48h-ZSCAN16_MA2100.1 18 bp overlap

Motif DE_60h DE_60h-ZSCAN16_MA2100.1 18 bp overlap

Zfp809 2 datasets

Motif DE_48h DE_48h-Zfp809_MA2125.1 9 bp overlap

Motif DE_60h DE_60h-Zfp809_MA2125.1 9 bp overlap

Motif DE_36h DE_36h-Zfx_MA0146.3 10 bp overlap

Motif DE_48h DE_48h-Zfx_MA0146.3 10 bp overlap

Motif DE_60h DE_60h-Zfx_MA0146.3 10 bp overlap