chr4 : 99,084,444 – 99,085,306

862 bp 89 TFs 2 linked genes

This 862 bp open chromatin element is linked to ADH5 and ENSG00000246090 and is bound by 89 transcription factors.

Linked Genes

2 genes

Gene	Expression	Dist. to TSS	Distance	Link type
ADH5		3.4 kb	Proximal	Proximity
ENSG00000246090		3.6 kb	Proximal	Proximity

Chromatin Accessibility

Genome Browser

Genomic view centred on this element. Tracks include ATAC-seq accessibility, RNA-seq expression, TF binding peaks, and element-to-gene loop arcs across the ESC → DE time course.

Transcription factors with ChIP-seq peak overlap or TOBIAS motif footprint evidence at this element.

TF Binding

89 transcription factors

Crx 1 dataset

Motif DE_60h DE_60h-Crx_MA0467.3 6 bp overlap

DMRT3 1 dataset

Motif DE_60h DE_60h-DMRT3_MA0610.2 7 bp overlap

DMRTA1 1 dataset

Motif DE_60h DE_60h-DMRTA1_MA1707.2 10 bp overlap

DMRTC2 1 dataset

Motif DE_60h DE_60h-DMRTC2_MA1479.2 11 bp overlap

EBF3 1 dataset

Motif DE_60h DE_60h-EBF3_MA1637.2 9 bp overlap

EMSY 1 dataset

ChIP K562 ENCFF511ZZZ 275 bp overlap

EOMES 1 dataset

ChIP hESC GSE26097.EOMES.hESC 554 bp overlap

ESR1 1 dataset

ChIP U2OS_100nM-E2 GSE151039.ESR1.U2OS_100nM-E2 143 bp overlap

ESRRA 1 dataset

Motif DE_60h DE_60h-ESRRA_MA0592.4 9 bp overlap

ESRRB 1 dataset

Motif DE_60h DE_60h-ESRRB_MA0141.4 10 bp overlap

Ebf2 1 dataset

Motif DE_60h DE_60h-Ebf2_MA1604.2 9 bp overlap

FEZF2 2 datasets

Motif DE_60h DE_60h-FEZF2_MA2341.1 8 bp overlap

FOS 1 dataset

ChIP HCT-116_A7A GSE152144.FOS.HCT-116_A7A 433 bp overlap

FOXA2 2 datasets

ChIP DE DE-FOXA2-1 658 bp overlap

ChIP DE DE-FOXA2-2 554 bp overlap

GATA2 1 dataset

Motif DE_60h DE_60h-GATA2_MA0036.4 7 bp overlap

GATA4 3 datasets

ChIP DE DE-GATA4-1 717 bp overlap

ChIP DE DE-GATA4-2 820 bp overlap

Motif DE_60h DE_60h-GATA4_MA0482.3 8 bp overlap

GATA5 1 dataset

Motif DE_60h DE_60h-GATA5_MA0766.3 8 bp overlap

GATA6 7 datasets

ChIP DE DE-GATA6-1 716 bp overlap

ChIP DE DE-GATA6-2 840 bp overlap

Motif DE_60h DE_60h-GATA6_MA1104.3 8 bp overlap

ChIP DE_D1 S14-DE-d1-GATA6-exp1 329 bp overlap

ChIP DE_D2 S55-DE-d2-GATA6-exp2 757 bp overlap

ChIP HUES-8_DE_JNKi GSE109524.GATA6.HUES-8_DE_JNKi 575 bp overlap

ChIP endoderm_KO GSE117136.GATA6.endoderm_KO 703 bp overlap

GFI1 1 dataset

Motif DE_60h DE_60h-GFI1_MA0038.3 11 bp overlap

GSC 1 dataset

Motif DE_60h DE_60h-GSC_MA0648.2 6 bp overlap

GSC2 1 dataset

Motif DE_60h DE_60h-GSC2_MA0891.2 6 bp overlap

Gata3 1 dataset

Motif DE_60h DE_60h-Gata3_MA0037.5 8 bp overlap

Gfi1B 1 dataset

Motif DE_60h DE_60h-Gfi1B_MA0483.2 10 bp overlap

HOXA4 1 dataset

Motif DE_60h DE_60h-HOXA4_MA1496.2 7 bp overlap

HOXB4 1 dataset

Motif DE_60h DE_60h-HOXB4_MA1499.2 6 bp overlap

HOXC4 1 dataset

Motif DE_60h DE_60h-HOXC4_MA1504.2 6 bp overlap

HOXD12::ELK1 1 dataset

Motif DE_60h DE_60h-HOXD12ELK1_MA1958.2 13 bp overlap

HOXD4 1 dataset

Motif DE_60h DE_60h-HOXD4_MA1507.2 6 bp overlap

Hnf1A 2 datasets

Motif DE_36h DE_36h-Hnf1A_MA1991.2 10 bp overlap

Motif DE_60h DE_60h-Hnf1A_MA1991.2 10 bp overlap

Hoxd13 1 dataset

Motif DE_60h DE_60h-Hoxd13_MA0909.4 7 bp overlap

IRF2 1 dataset

Motif DE_60h DE_60h-IRF2_MA0051.2 16 bp overlap

IRF3 2 datasets

Motif DE_36h DE_36h-IRF3_MA1418.2 17 bp overlap

Motif DE_60h DE_60h-IRF3_MA1418.2 17 bp overlap

IRF4 1 dataset

Motif DE_60h DE_60h-IRF4_MA1419.2 14 bp overlap

IRF5 1 dataset

Motif DE_60h DE_60h-IRF5_MA1420.1 14 bp overlap

IRF7 2 datasets

Motif DE_36h DE_36h-IRF7_MA0772.2 13 bp overlap

Motif DE_60h DE_60h-IRF7_MA0772.2 13 bp overlap

IRF8 1 dataset

Motif DE_60h DE_60h-IRF8_MA0652.2 13 bp overlap

IRF9 2 datasets

Motif DE_36h DE_36h-IRF9_MA0653.1 15 bp overlap

Motif DE_60h DE_60h-IRF9_MA0653.1 15 bp overlap

Irf1 2 datasets

Motif DE_36h DE_36h-Irf1_MA0050.4 11 bp overlap

Motif DE_60h DE_60h-Irf1_MA0050.4 11 bp overlap

MAFF 4 datasets

ChIP HeLa-S3 ENCSR140DSL.MAFF.HeLa-S3 152 bp overlap

ChIP HepG2 ENCFF452YUT 142 bp overlap

ChIP K-562 ENCSR000EGI.MAFF.K-562 206 bp overlap

ChIP K562 ENCFF071YKK 281 bp overlap

MAFG 2 datasets

ChIP K-562 ENCSR818DQV.MAFG.K-562 365 bp overlap

ChIP K562 ENCFF455EEO 445 bp overlap

MAFK 8 datasets

ChIP A549 ENCFF371EPR 238 bp overlap

ChIP HeLa-S3 ENCSR000ECK.MAFK.HeLa-S3 231 bp overlap

ChIP Hep-G2 ENCSR000EDZ.MAFK.Hep-G2 201 bp overlap

ChIP HepG2 ENCFF743ZOF 151 bp overlap

ChIP HepG2 ENCFF767LDG 257 bp overlap

ChIP IMR-90 ENCFF336DHZ 271 bp overlap

ChIP K-562 ENCSR000EGX.MAFK.K-562 163 bp overlap

ChIP K562 ENCFF380WHM 281 bp overlap

MEIS1 1 dataset

Motif DE_60h DE_60h-MEIS1_MA0498.3 5 bp overlap

MSC 1 dataset

Motif DE_60h DE_60h-MSC_MA0665.1 10 bp overlap

MYBL2 1 dataset

ChIP A-673 GSE119971.MYBL2.A-673 202 bp overlap

MZF1 1 dataset

Motif DE_60h DE_60h-MZF1_MA0056.3 8 bp overlap

Mecom 1 dataset

Motif DE_60h DE_60h-Mecom_MA0029.2 11 bp overlap

NFATC3 1 dataset

Motif DE_60h DE_60h-NFATC3_MA0625.3 6 bp overlap

NR1D1 1 dataset

Motif DE_60h DE_60h-NR1D1_MA1531.2 14 bp overlap

NR1D2 1 dataset

Motif DE_60h DE_60h-NR1D2_MA1532.2 15 bp overlap

NR1I2 1 dataset

Motif DE_60h DE_60h-NR1I2_MA1533.2 15 bp overlap

Nfatc1 1 dataset

Motif DE_60h DE_60h-Nfatc1_MA0624.3 6 bp overlap

Nr2e1 1 dataset

Motif DE_60h DE_60h-Nr2e1_MA0676.1 9 bp overlap

Nr5A2 1 dataset

Motif DE_60h DE_60h-Nr5A2_MA0505.3 9 bp overlap

OTX1 1 dataset

Motif DE_60h DE_60h-OTX1_MA0711.2 6 bp overlap

PITX1 1 dataset

Motif DE_60h DE_60h-PITX1_MA0682.3 6 bp overlap

PITX3 1 dataset

Motif DE_60h DE_60h-PITX3_MA0714.2 6 bp overlap

POLR2G 2 datasets

ChIP HepG2 ENCFF508UTS 120 bp overlap

ChIP HepG2 ENCFF508UTS 554 bp overlap

POU6F1 1 dataset

Motif DE_60h DE_60h-POU6F1_MA1549.2 7 bp overlap

PPARA::RXRA 1 dataset

Motif DE_60h DE_60h-PPARARXRA_MA1148.2 17 bp overlap

PPARD 1 dataset

Motif DE_60h DE_60h-PPARD_MA1550.2 14 bp overlap

Prdm5 1 dataset

Motif DE_60h DE_60h-Prdm5_MA1999.2 11 bp overlap

RARA::RXRG 1 dataset

Motif DE_60h DE_60h-RARARXRG_MA1149.2 17 bp overlap

RBPJ 1 dataset

Motif DE_60h DE_60h-RBPJ_MA1116.2 6 bp overlap

RHOXF1 1 dataset

Motif DE_60h DE_60h-RHOXF1_MA0719.2 6 bp overlap

RXRA::VDR 1 dataset

Motif DE_60h DE_60h-RXRAVDR_MA0074.1 15 bp overlap

RXRG 1 dataset

Motif DE_60h DE_60h-RXRG_MA1556.1 14 bp overlap

Rarb 1 dataset

Motif DE_60h DE_60h-Rarb_MA0858.1 17 bp overlap

SFPQ 1 dataset

ChIP LTAD_EtOH GSE94577.SFPQ.LTAD_EtOH 178 bp overlap

SMAD2-3 1 dataset

ChIP HUES-8_DE GSE109524.SMAD2-3.HUES-8_DE 587 bp overlap

SMAD2_3 2 datasets

ChIP DE_D2 S01-DE-d2-SMAD2_3-exp1 582 bp overlap

ChIP DE_D2 S53-DE-d2-SMAD2_3-exp2 377 bp overlap

SOX17 1 dataset

ChIP DE_D2 DED2-SOX17_Batch_II 336 bp overlap

SOX17_M 1 dataset

ChIP DE_D2 DED2-SOX17-M_Batch_II 519 bp overlap

SP5 1 dataset

Motif DE_60h DE_60h-SP5_MA1965.2 6 bp overlap

STAT1 1 dataset

ChIP HeLa-S3 ENCSR000EZK.STAT1.HeLa-S3 130 bp overlap

STAT1_pS727 1 dataset

ChIP SET-2 GSE100566.STAT1_pS727.SET-2 279 bp overlap

Stat2 2 datasets

Motif DE_36h DE_36h-Stat2_MA1623.2 10 bp overlap

Motif DE_60h DE_60h-Stat2_MA1623.2 10 bp overlap

TCF7L1 1 dataset

Motif DE_60h DE_60h-TCF7L1_MA1421.1 12 bp overlap

TCF7L2 2 datasets

Motif DE_36h DE_36h-TCF7L2_MA0523.2 9 bp overlap

Motif DE_60h DE_60h-TCF7L2_MA0523.2 9 bp overlap

TFAP2B 1 dataset

Motif DE_60h DE_60h-TFAP2B_MA0813.1 13 bp overlap

TRPS1 1 dataset

Motif DE_60h DE_60h-TRPS1_MA1970.2 8 bp overlap

ZNF316 1 dataset

ChIP K562 ENCFF838QCD 308 bp overlap

ZNF317 1 dataset

Motif DE_60h DE_60h-ZNF317_MA1593.2 8 bp overlap

ZNF384 1 dataset

Motif DE_60h DE_60h-ZNF384_MA1125.2 8 bp overlap

ZNF460 1 dataset

Motif DE_60h DE_60h-ZNF460_MA1596.1 16 bp overlap

ZNF558 1 dataset

Motif DE_60h DE_60h-ZNF558_MA2335.1 29 bp overlap

ZNF675 1 dataset

Motif DE_60h DE_60h-ZNF675_MA1714.2 19 bp overlap

ZNF684 1 dataset

Motif DE_60h DE_60h-ZNF684_MA1600.2 14 bp overlap

ZNF770 1 dataset

Motif DE_60h DE_60h-ZNF770_MA2099.1 8 bp overlap

Zfp961 1 dataset

Motif DE_60h DE_60h-Zfp961_MA2126.1 8 bp overlap