chr4 : 140,349,706 – 140,350,239
533 bp 64 TFs 5 linked genes
This 533 bp open chromatin element is linked to 5 target genes and is bound by 64 transcription factors.
Linked Genes
5 genes
Link type
Gene↕ Expression Dist. to TSS↑ Distance↕ Link type↕
SCOC 23.7 kb Distal Multiome
CLGN 77.6 kb Distal Multiome
ELMOD2 174.2 kb Distal Multiome
MAML3 195.8 kb Distal Multiome+HiCAR
MGST2 684.2 kb Distal Multiome+HiCAR
Chromatin Accessibility

Genome Browser

Genomic view centred on this element. Tracks include ATAC-seq accessibility, RNA-seq expression, TF binding peaks, and element-to-gene loop arcs across the ESC → DE time course.

View limited to ±500 kb around this element.
For the full data, please see the UCSC track linked below.
chr4:140,344,706 – 140,355,239
This element Other elements Gene links ATAC-seq RNA-seq

Transcription factors with ChIP-seq peak overlap or TOBIAS motif footprint evidence at this element.

TF Binding
64 transcription factors
Source
Cell type
CBX8 1 dataset
ChIP K-562 ENCSR000ATW.CBX8.K-562 97 bp overlap
CTCF 6 datasets
Motif DE_12h DE_12h-CTCF_MA1929.2 31 bp overlap
Motif DE_12h DE_12h-CTCF_MA1930.2 33 bp overlap
Motif DE_36h DE_36h-CTCF_MA1929.2 31 bp overlap
Motif DE_36h DE_36h-CTCF_MA1930.2 33 bp overlap
Motif DE_48h DE_48h-CTCF_MA1929.2 31 bp overlap
Motif DE_48h DE_48h-CTCF_MA1930.2 33 bp overlap
E2F6 3 datasets
Motif DE_12h DE_12h-E2F6_MA0471.3 8 bp overlap
Motif DE_36h DE_36h-E2F6_MA0471.3 8 bp overlap
Motif DE_48h DE_48h-E2F6_MA0471.3 8 bp overlap
EHF 3 datasets
Motif DE_12h DE_12h-EHF_MA0598.4 9 bp overlap
Motif DE_36h DE_36h-EHF_MA0598.4 9 bp overlap
Motif DE_48h DE_48h-EHF_MA0598.4 9 bp overlap
ELF1 3 datasets
Motif DE_12h DE_12h-ELF1_MA0473.4 9 bp overlap
Motif DE_36h DE_36h-ELF1_MA0473.4 9 bp overlap
Motif DE_48h DE_48h-ELF1_MA0473.4 9 bp overlap
ELF3 3 datasets
Motif DE_12h DE_12h-ELF3_MA0640.3 9 bp overlap
Motif DE_36h DE_36h-ELF3_MA0640.3 9 bp overlap
Motif DE_48h DE_48h-ELF3_MA0640.3 9 bp overlap
ELK4 3 datasets
Motif DE_12h DE_12h-ELK4_MA0076.3 9 bp overlap
Motif DE_36h DE_36h-ELK4_MA0076.3 9 bp overlap
Motif DE_48h DE_48h-ELK4_MA0076.3 9 bp overlap
EOMES 1 dataset
ChIP hESC GSE26097.EOMES.hESC 357 bp overlap
ESR1 1 dataset
ChIP breast-cancer_3487 GSE126004.ESR1.breast-cancer_3487 157 bp overlap
ETV1 3 datasets
Motif DE_12h DE_12h-ETV1_MA0761.3 9 bp overlap
Motif DE_36h DE_36h-ETV1_MA0761.3 9 bp overlap
Motif DE_48h DE_48h-ETV1_MA0761.3 9 bp overlap
Erg 3 datasets
Motif DE_12h DE_12h-Erg_MA0474.4 10 bp overlap
Motif DE_36h DE_36h-Erg_MA0474.4 10 bp overlap
Motif DE_48h DE_48h-Erg_MA0474.4 10 bp overlap
FEZF1 1 dataset
ChIP HEK293 GSE76494.FEZF1.HEK293 179 bp overlap
FOXA1 2 datasets
ChIP breast-cancer_Veh-2856 GSE128018.FOXA1.breast-cancer_Veh-2856 212 bp overlap
ChIP breast-cancer_Veh-2860 GSE128018.FOXA1.breast-cancer_Veh-2860 180 bp overlap
GABPA 3 datasets
Motif DE_12h DE_12h-GABPA_MA0062.4 10 bp overlap
Motif DE_36h DE_36h-GABPA_MA0062.4 10 bp overlap
Motif DE_48h DE_48h-GABPA_MA0062.4 10 bp overlap
GATA4 2 datasets
ChIP DE DE-GATA4-1 415 bp overlap
ChIP DE DE-GATA4-2 387 bp overlap
GATA6 9 datasets
ChIP DE DE-GATA6-1 441 bp overlap
ChIP DE DE-GATA6-2 451 bp overlap
ChIP DE_D1 S09-DE-d1-GATA6-exp1 533 bp overlap
ChIP DE_D1 S14-DE-d1-GATA6-exp1 533 bp overlap
ChIP DE_D1 S41-DE-d1-GATA6-exp2 533 bp overlap
ChIP DE_D2 S55-DE-d2-GATA6-exp2 477 bp overlap
ChIP HUES-8_DE_JNKi GSE109524.GATA6.HUES-8_DE_JNKi 533 bp overlap
ChIP HUES-8_DE_ctrl GSE109524.GATA6.HUES-8_DE_ctrl 533 bp overlap
ChIP endoderm_KO GSE117136.GATA6.endoderm_KO 449 bp overlap
GFI1 2 datasets
Motif DE_12h DE_12h-GFI1_MA0038.3 11 bp overlap
Motif DE_36h DE_36h-GFI1_MA0038.3 11 bp overlap
Hmx2 2 datasets
Motif DE_12h DE_12h-Hmx2_MA0897.2 15 bp overlap
Motif DE_36h DE_36h-Hmx2_MA0897.2 15 bp overlap
IRF3 3 datasets
Motif DE_12h DE_12h-IRF3_MA1418.2 17 bp overlap
Motif DE_36h DE_36h-IRF3_MA1418.2 17 bp overlap
Motif DE_48h DE_48h-IRF3_MA1418.2 17 bp overlap
ISL2 3 datasets
Motif DE_12h DE_12h-ISL2_MA0914.2 6 bp overlap
Motif DE_36h DE_36h-ISL2_MA0914.2 6 bp overlap
Motif DE_48h DE_48h-ISL2_MA0914.2 6 bp overlap
Ikzf3 3 datasets
Motif DE_12h DE_12h-Ikzf3_MA1992.2 9 bp overlap
Motif DE_36h DE_36h-Ikzf3_MA1992.2 9 bp overlap
Motif DE_48h DE_48h-Ikzf3_MA1992.2 9 bp overlap
Irf1 3 datasets
Motif DE_12h DE_12h-Irf1_MA0050.4 11 bp overlap
Motif DE_36h DE_36h-Irf1_MA0050.4 11 bp overlap
Motif DE_48h DE_48h-Irf1_MA0050.4 11 bp overlap
JUN 4 datasets
ChIP DE_D1 S08-DE-d1-JUN-exp1 256 bp overlap
ChIP DE_D1 S40-DE-d1-JUN-exp2 328 bp overlap
ChIP HAEC_oxpapc_4h GSE89970.JUN.HAEC_oxpapc_4h 229 bp overlap
ChIP HUES-8_DE_ctrl GSE109524.JUN.HUES-8_DE_ctrl 331 bp overlap
MEIS1 3 datasets
Motif DE_12h DE_12h-MEIS1_MA0498.3 5 bp overlap
Motif DE_36h DE_36h-MEIS1_MA0498.3 5 bp overlap
Motif DE_48h DE_48h-MEIS1_MA0498.3 5 bp overlap
Mecom 2 datasets
Motif DE_12h DE_12h-Mecom_MA0029.2 11 bp overlap
Motif DE_36h DE_36h-Mecom_MA0029.2 11 bp overlap
NANOG 6 datasets
ChIP HUES-8 GSE109524.NANOG.HUES-8 353 bp overlap
ChIP WA01 ERP004238.NANOG.WA01 205 bp overlap
ChIP WA01_3IL ERP004238.NANOG.WA01_3IL 533 bp overlap
ChIP WA09 GSE105028.NANOG.WA09 258 bp overlap
ChIP WA09_heat-shock GSE105028.NANOG.WA09_heat-shock 238 bp overlap
ChIP hESC GSE18292.NANOG.hESC 133 bp overlap
NIPBL 1 dataset
ChIP hESC_WNT3A_ACTIVIN GSE64758.NIPBL.hESC_WNT3A_ACTIVIN 237 bp overlap
Nkx3-2 3 datasets
Motif DE_12h DE_12h-Nkx3-2_MA0122.4 10 bp overlap
Motif DE_36h DE_36h-Nkx3-2_MA0122.4 10 bp overlap
Motif DE_48h DE_48h-Nkx3-2_MA0122.4 10 bp overlap
ONECUT1 2 datasets
Motif DE_12h DE_12h-ONECUT1_MA0679.3 9 bp overlap
Motif DE_36h DE_36h-ONECUT1_MA0679.3 9 bp overlap
ONECUT3 2 datasets
Motif DE_12h DE_12h-ONECUT3_MA0757.2 12 bp overlap
Motif DE_36h DE_36h-ONECUT3_MA0757.2 12 bp overlap
PBX1 2 datasets
Motif DE_12h DE_12h-PBX1_MA0070.2 9 bp overlap
Motif DE_36h DE_36h-PBX1_MA0070.2 9 bp overlap
POU2F1 3 datasets
Motif DE_12h DE_12h-POU2F1_MA0785.2 9 bp overlap
Motif DE_36h DE_36h-POU2F1_MA0785.2 9 bp overlap
Motif DE_48h DE_48h-POU2F1_MA0785.2 9 bp overlap
POU3F4 3 datasets
Motif DE_12h DE_12h-POU3F4_MA0789.1 9 bp overlap
Motif DE_36h DE_36h-POU3F4_MA0789.1 9 bp overlap
Motif DE_48h DE_48h-POU3F4_MA0789.1 9 bp overlap
POU5F1 2 datasets
ChIP DE_D1 DED1-OCT4_Batch_II 296 bp overlap
ChIP NCCIT_SNF5 GSE36134.POU5F1.NCCIT_SNF5 468 bp overlap
POU5F1B 3 datasets
Motif DE_12h DE_12h-POU5F1B_MA0792.1 9 bp overlap
Motif DE_36h DE_36h-POU5F1B_MA0792.1 9 bp overlap
Motif DE_48h DE_48h-POU5F1B_MA0792.1 9 bp overlap
RBPJ 3 datasets
Motif DE_12h DE_12h-RBPJ_MA1116.2 6 bp overlap
Motif DE_36h DE_36h-RBPJ_MA1116.2 6 bp overlap
Motif DE_48h DE_48h-RBPJ_MA1116.2 6 bp overlap
RNF2 1 dataset
ChIP fibroblast GSE139053.RNF2.fibroblast 176 bp overlap
SMAD1 1 dataset
ChIP BG03 GSE36578.SMAD1.BG03 98 bp overlap
SMAD2 2 datasets
Motif DE_12h DE_12h-SMAD2_MA1964.2 6 bp overlap
Motif DE_36h DE_36h-SMAD2_MA1964.2 6 bp overlap
SMAD2-3 3 datasets
ChIP HUES-8_DE GSE109524.SMAD2-3.HUES-8_DE 453 bp overlap
ChIP HUES-8_DE_JNKi GSE109524.SMAD2-3.HUES-8_DE_JNKi 484 bp overlap
ChIP HUES-8_DE_ctrl GSE109524.SMAD2-3.HUES-8_DE_ctrl 479 bp overlap
SMAD2_3 4 datasets
ChIP DE_D1 S07-DE-d1-SMAD2_3-exp1 270 bp overlap
ChIP DE_D1 S12-DE-d1-SMAD2_3-exp1 360 bp overlap
ChIP DE_D1 S39-DE-d1-SMAD2_3-exp2 391 bp overlap
ChIP DE_D2 S01-DE-d2-SMAD2_3-exp1 313 bp overlap
SMARCA4 2 datasets
ChIP hiPSC GSE124903.SMARCA4.hiPSC 366 bp overlap
ChIP hiPSC_WT GSE124903.SMARCA4.hiPSC_WT 253 bp overlap
SMARCB1 1 dataset
ChIP hiPSC GSE124903.SMARCB1.hiPSC 224 bp overlap
SMARCC1 2 datasets
ChIP hiPSC GSE124903.SMARCC1.hiPSC 211 bp overlap
ChIP hiPSC_WT GSE124903.SMARCC1.hiPSC_WT 304 bp overlap
SOX14 2 datasets
Motif DE_12h DE_12h-SOX14_MA1562.2 9 bp overlap
Motif DE_36h DE_36h-SOX14_MA1562.2 9 bp overlap
SOX17 1 dataset
ChIP DE_D2 DED2-SOX17_Batch_II 321 bp overlap
SOX17_M 1 dataset
ChIP DE_D2 DED2-SOX17-M_Batch_II 387 bp overlap
STAT1::STAT2 3 datasets
Motif DE_12h DE_12h-STAT1STAT2_MA0517.2 13 bp overlap
Motif DE_36h DE_36h-STAT1STAT2_MA0517.2 13 bp overlap
Motif DE_48h DE_48h-STAT1STAT2_MA0517.2 13 bp overlap
STAT1_pS727 1 dataset
ChIP SET-2 GSE100566.STAT1_pS727.SET-2 261 bp overlap
Stat2 2 datasets
Motif DE_12h DE_12h-Stat2_MA1623.2 10 bp overlap
Motif DE_36h DE_36h-Stat2_MA1623.2 10 bp overlap
T 1 dataset
ChIP H9_MESODERM GSE60606.T.H9_MESODERM 271 bp overlap
TP53 3 datasets
Motif DE_12h DE_12h-TP53_MA0106.3 18 bp overlap
Motif DE_36h DE_36h-TP53_MA0106.3 18 bp overlap
Motif DE_48h DE_48h-TP53_MA0106.3 18 bp overlap
TP73 3 datasets
Motif DE_12h DE_12h-TP73_MA0861.2 16 bp overlap
Motif DE_36h DE_36h-TP73_MA0861.2 16 bp overlap
Motif DE_48h DE_48h-TP73_MA0861.2 16 bp overlap
ZIC2 1 dataset
ChIP HEK293 ENCFF033NQQ 155 bp overlap
ZNF10 1 dataset
ChIP HEK293T GSE78099.ZNF10.HEK293T 293 bp overlap
ZNF16 5 datasets
Motif DE_12h DE_12h-ZNF16_MA1654.2 21 bp overlap
Motif DE_12h DE_12h-ZNF16_MA1654.2 21 bp overlap
Motif DE_36h DE_36h-ZNF16_MA1654.2 21 bp overlap
Motif DE_36h DE_36h-ZNF16_MA1654.2 21 bp overlap
Motif DE_48h DE_48h-ZNF16_MA1654.2 21 bp overlap
ZNF324 3 datasets
Motif DE_12h DE_12h-ZNF324_MA1977.2 14 bp overlap
Motif DE_36h DE_36h-ZNF324_MA1977.2 14 bp overlap
Motif DE_48h DE_48h-ZNF324_MA1977.2 14 bp overlap
ZNF382 2 datasets
Motif DE_12h DE_12h-ZNF382_MA1594.1 24 bp overlap
Motif DE_36h DE_36h-ZNF382_MA1594.1 24 bp overlap
ZNF398 1 dataset
ChIP H9 GSE133630.ZNF398.H9 154 bp overlap
ZNF75D 3 datasets
Motif DE_12h DE_12h-ZNF75D_MA1601.2 12 bp overlap
Motif DE_36h DE_36h-ZNF75D_MA1601.2 12 bp overlap
Motif DE_48h DE_48h-ZNF75D_MA1601.2 12 bp overlap
ZSCAN4 1 dataset
Motif DE_36h DE_36h-ZSCAN4_MA1155.1 15 bp overlap
Zfp335 1 dataset
Motif DE_36h DE_36h-Zfp335_MA2002.2 7 bp overlap
Zfp809 3 datasets
Motif DE_12h DE_12h-Zfp809_MA2125.1 9 bp overlap
Motif DE_36h DE_36h-Zfp809_MA2125.1 9 bp overlap
Motif DE_48h DE_48h-Zfp809_MA2125.1 9 bp overlap
Zic2 3 datasets
Motif DE_12h DE_12h-Zic2_MA1629.2 9 bp overlap
Motif DE_36h DE_36h-Zic2_MA1629.2 9 bp overlap
Motif DE_48h DE_48h-Zic2_MA1629.2 9 bp overlap
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