chr4 : 173,343,696 – 173,344,345

649 bp 92 TFs 2 linked genes

This 649 bp open chromatin element is linked to ENSG00000288728 and HMGB2 and is bound by 92 transcription factors.

Linked Genes

2 genes

Gene	Expression	Dist. to TSS	Distance	Link type
ENSG00000288728		8.9 kb	Proximal	Proximity
HMGB2		9.3 kb	Proximal	Proximity

Chromatin Accessibility

Genome Browser

Genomic view centred on this element. Tracks include ATAC-seq accessibility, RNA-seq expression, TF binding peaks, and element-to-gene loop arcs across the ESC → DE time course.

Transcription factors with ChIP-seq peak overlap or TOBIAS motif footprint evidence at this element.

TF Binding

92 transcription factors

Atoh1 2 datasets

Motif DE_48h DE_48h-Atoh1_MA1467.3 7 bp overlap

Motif DE_60h DE_60h-Atoh1_MA1467.3 7 bp overlap

CDK6 1 dataset

ChIP KB_IL GSE52469.CDK6.KB_IL 100 bp overlap

CDX2 2 datasets

Motif DE_48h DE_48h-CDX2_MA0465.3 8 bp overlap

Motif DE_60h DE_60h-CDX2_MA0465.3 8 bp overlap

CTCF 1 dataset

Motif DE_60h DE_60h-CTCF_MA0139.2 15 bp overlap

Crx 3 datasets

Motif DE_48h DE_48h-Crx_MA0467.3 6 bp overlap

Motif DE_60h DE_60h-Crx_MA0467.3 6 bp overlap

Motif DE_72h DE_72h-Crx_MA0467.3 6 bp overlap

EED 1 dataset

ChIP ProEs GSE59087.EED.ProEs 214 bp overlap

EOMES 1 dataset

ChIP hESC GSE26097.EOMES.hESC 195 bp overlap

ERF::FIGLA 1 dataset

Motif DE_60h DE_60h-ERFFIGLA_MA1934.2 13 bp overlap

ERF::FOXI1 1 dataset

Motif DE_60h DE_60h-ERFFOXI1_MA1935.2 10 bp overlap

ERF::FOXO1 2 datasets

Motif DE_48h DE_48h-ERFFOXO1_MA1936.2 12 bp overlap

Motif DE_60h DE_60h-ERFFOXO1_MA1936.2 12 bp overlap

ERG 1 dataset

ChIP arterial-endothelial-cells GSE128382.ERG.arterial-endothelial-cells 157 bp overlap

ESR1 2 datasets

ChIP MCF-7_SHFOXA1_E2 ERP000380.ESR1.MCF-7_SHFOXA1_E2 118 bp overlap

ChIP MDA-MB-134-VI_ESTROGEN GSE51022.ESR1.MDA-MB-134-VI_ESTROGEN 277 bp overlap

ETV2::FIGLA 1 dataset

Motif DE_60h DE_60h-ETV2FIGLA_MA1941.2 13 bp overlap

ETV5::FIGLA 1 dataset

Motif DE_60h DE_60h-ETV5FIGLA_MA1945.2 14 bp overlap

FOXA2 2 datasets

ChIP DE DE-FOXA2-1 609 bp overlap

ChIP DE DE-FOXA2-2 621 bp overlap

FOXP2 2 datasets

Motif DE_48h DE_48h-FOXP2_MA0593.2 9 bp overlap

Motif DE_60h DE_60h-FOXP2_MA0593.2 9 bp overlap

Foxj3 2 datasets

Motif DE_48h DE_48h-Foxj3_MA0851.2 9 bp overlap

Motif DE_60h DE_60h-Foxj3_MA0851.2 9 bp overlap

GATA2 2 datasets

ChIP SH-SY5Y ENCSR000EYB.GATA2.SH-SY5Y 200 bp overlap

ChIP TF1 GSE73207.GATA2.TF1 302 bp overlap

GATA3 2 datasets

ChIP BE2C GSE65664.GATA3.BE2C 166 bp overlap

ChIP SK-N-BE2-C GSE94822.GATA3.SK-N-BE2-C 199 bp overlap

GATA3_Nter 1 dataset

ChIP T-47D_CR3flp GSE99479.GATA3_Nter.T-47D_CR3flp 159 bp overlap

GATA4 5 datasets

ChIP DE DE-GATA4-1 610 bp overlap

ChIP DE DE-GATA4-2 649 bp overlap

ChIP foregut GSE117136.GATA4.foregut 395 bp overlap

ChIP pancreatic-progenitor GSE117136.GATA4.pancreatic-progenitor 281 bp overlap

ChIP pancreatic-progenitor_PP1 GSE104840.GATA4.pancreatic-progenitor_PP1 305 bp overlap

GATA6 6 datasets

ChIP DE DE-GATA6-1 591 bp overlap

ChIP DE DE-GATA6-2 618 bp overlap

ChIP DE_D2 S55-DE-d2-GATA6-exp2 406 bp overlap

ChIP HUES-8_DE_JNKi GSE109524.GATA6.HUES-8_DE_JNKi 274 bp overlap

ChIP endoderm_KO GSE117136.GATA6.endoderm_KO 364 bp overlap

ChIP foregut GSE117136.GATA6.foregut 368 bp overlap

GSC 3 datasets

Motif DE_48h DE_48h-GSC_MA0648.2 6 bp overlap

Motif DE_60h DE_60h-GSC_MA0648.2 6 bp overlap

Motif DE_72h DE_72h-GSC_MA0648.2 6 bp overlap

GSC2 3 datasets

Motif DE_48h DE_48h-GSC2_MA0891.2 6 bp overlap

Motif DE_60h DE_60h-GSC2_MA0891.2 6 bp overlap

Motif DE_72h DE_72h-GSC2_MA0891.2 6 bp overlap

GTF2B 1 dataset

ChIP IMR-90_TERT GSE38303.GTF2B.IMR-90_TERT 140 bp overlap

HAND2 3 datasets

Motif DE_48h DE_48h-HAND2_MA1638.2 6 bp overlap

Motif DE_60h DE_60h-HAND2_MA1638.2 6 bp overlap

ChIP SK-N-BE2-C GSE94822.HAND2.SK-N-BE2-C 463 bp overlap

HOXA3 3 datasets

Motif DE_48h DE_48h-HOXA3_MA2119.1 7 bp overlap

Motif DE_60h DE_60h-HOXA3_MA2119.1 7 bp overlap

Motif DE_72h DE_72h-HOXA3_MA2119.1 7 bp overlap

HOXA4 3 datasets

Motif DE_48h DE_48h-HOXA4_MA1496.2 7 bp overlap

Motif DE_60h DE_60h-HOXA4_MA1496.2 7 bp overlap

Motif DE_72h DE_72h-HOXA4_MA1496.2 7 bp overlap

HOXB4 3 datasets

Motif DE_48h DE_48h-HOXB4_MA1499.2 6 bp overlap

Motif DE_60h DE_60h-HOXB4_MA1499.2 6 bp overlap

Motif DE_72h DE_72h-HOXB4_MA1499.2 6 bp overlap

HOXC4 3 datasets

Motif DE_48h DE_48h-HOXC4_MA1504.2 6 bp overlap

Motif DE_60h DE_60h-HOXC4_MA1504.2 6 bp overlap

Motif DE_72h DE_72h-HOXC4_MA1504.2 6 bp overlap

HOXD4 3 datasets

Motif DE_48h DE_48h-HOXD4_MA1507.2 6 bp overlap

Motif DE_60h DE_60h-HOXD4_MA1507.2 6 bp overlap

Motif DE_72h DE_72h-HOXD4_MA1507.2 6 bp overlap

Hand1::Tcf3 2 datasets

Motif DE_48h DE_48h-Hand1Tcf3_MA0092.2 9 bp overlap

Motif DE_60h DE_60h-Hand1Tcf3_MA0092.2 9 bp overlap

Hoxa13 2 datasets

Motif DE_48h DE_48h-Hoxa13_MA0650.4 8 bp overlap

Motif DE_60h DE_60h-Hoxa13_MA0650.4 8 bp overlap

Hoxd13 2 datasets

Motif DE_48h DE_48h-Hoxd13_MA0909.4 7 bp overlap

Motif DE_60h DE_60h-Hoxd13_MA0909.4 7 bp overlap

IKZF1 1 dataset

ChIP K-562 ENCSR395HWC.IKZF1.K-562 302 bp overlap

IRF2 1 dataset

ChIP keratinocyte_DOX GSE135677.IRF2.keratinocyte_DOX 182 bp overlap

IRF5 1 dataset

Motif DE_60h DE_60h-IRF5_MA1420.1 14 bp overlap

ISL1 1 dataset

ChIP SK-N-BE2-C GSE94822.ISL1.SK-N-BE2-C 553 bp overlap

ISL2 2 datasets

Motif DE_48h DE_48h-ISL2_MA0914.2 6 bp overlap

Motif DE_60h DE_60h-ISL2_MA0914.2 6 bp overlap

KLF3 2 datasets

Motif DE_48h DE_48h-KLF3_MA1516.2 10 bp overlap

Motif DE_60h DE_60h-KLF3_MA1516.2 10 bp overlap

KLF4 1 dataset

ChIP hiPSC GSE56567.KLF4.hiPSC 175 bp overlap

MYCN 1 dataset

ChIP Kelly GSE94822.MYCN.Kelly 129 bp overlap

NANOG 4 datasets

ChIP HUES-8 GSE109524.NANOG.HUES-8 489 bp overlap

ChIP WA01_3IL ERP004238.NANOG.WA01_3IL 181 bp overlap

ChIP WA09 GSE105028.NANOG.WA09 480 bp overlap

ChIP hESC GSE18292.NANOG.hESC 118 bp overlap

NEUROG2 2 datasets

Motif DE_48h DE_48h-NEUROG2_MA1642.2 7 bp overlap

Motif DE_60h DE_60h-NEUROG2_MA1642.2 7 bp overlap

NFATC3 1 dataset

Motif DE_60h DE_60h-NFATC3_MA0625.3 6 bp overlap

NFKB1 1 dataset

ChIP L1236 GSE63736.NFKB1.L1236 154 bp overlap

NKX2-3 2 datasets

Motif DE_48h DE_48h-NKX2-3_MA0672.2 8 bp overlap

Motif DE_60h DE_60h-NKX2-3_MA0672.2 8 bp overlap

NKX6-3 3 datasets

Motif DE_48h DE_48h-NKX6-3_MA1530.2 8 bp overlap

Motif DE_60h DE_60h-NKX6-3_MA1530.2 8 bp overlap

Motif DE_72h DE_72h-NKX6-3_MA1530.2 8 bp overlap

NR6A1 2 datasets

Motif DE_48h DE_48h-NR6A1_MA1541.2 14 bp overlap

Motif DE_60h DE_60h-NR6A1_MA1541.2 14 bp overlap

NUTM1 1 dataset

ChIP embryonic-kidney_induced GSE133122.NUTM1.embryonic-kidney_induced 649 bp overlap

Nfatc1 1 dataset

Motif DE_60h DE_60h-Nfatc1_MA0624.3 6 bp overlap

Nfatc2 1 dataset

Motif DE_60h DE_60h-Nfatc2_MA0152.3 8 bp overlap

Nkx3-1 2 datasets

Motif DE_48h DE_48h-Nkx3-1_MA0124.3 7 bp overlap

Motif DE_60h DE_60h-Nkx3-1_MA0124.3 7 bp overlap

Nkx3-2 2 datasets

Motif DE_48h DE_48h-Nkx3-2_MA0122.4 10 bp overlap

Motif DE_60h DE_60h-Nkx3-2_MA0122.4 10 bp overlap

ONECUT1 1 dataset

ChIP pancreatic-progenitor_PP1 GSE104840.ONECUT1.pancreatic-progenitor_PP1 427 bp overlap

ONECUT3 2 datasets

Motif DE_48h DE_48h-ONECUT3_MA0757.2 12 bp overlap

Motif DE_60h DE_60h-ONECUT3_MA0757.2 12 bp overlap

OTX1 3 datasets

Motif DE_48h DE_48h-OTX1_MA0711.2 6 bp overlap

Motif DE_60h DE_60h-OTX1_MA0711.2 6 bp overlap

Motif DE_72h DE_72h-OTX1_MA0711.2 6 bp overlap

OTX2 3 datasets

Motif DE_48h DE_48h-OTX2_MA0712.3 7 bp overlap

Motif DE_60h DE_60h-OTX2_MA0712.3 7 bp overlap

Motif DE_72h DE_72h-OTX2_MA0712.3 7 bp overlap

PATZ1 2 datasets

Motif DE_48h DE_48h-PATZ1_MA1961.2 11 bp overlap

Motif DE_60h DE_60h-PATZ1_MA1961.2 11 bp overlap

PHOX2B 1 dataset

ChIP SK-N-BE2-C GSE94822.PHOX2B.SK-N-BE2-C 172 bp overlap

PITX1 3 datasets

Motif DE_48h DE_48h-PITX1_MA0682.3 6 bp overlap

Motif DE_60h DE_60h-PITX1_MA0682.3 6 bp overlap

Motif DE_72h DE_72h-PITX1_MA0682.3 6 bp overlap

PITX2 3 datasets

Motif DE_48h DE_48h-PITX2_MA1547.2 8 bp overlap

Motif DE_60h DE_60h-PITX2_MA1547.2 8 bp overlap

Motif DE_72h DE_72h-PITX2_MA1547.2 8 bp overlap

PITX3 3 datasets

Motif DE_48h DE_48h-PITX3_MA0714.2 6 bp overlap

Motif DE_60h DE_60h-PITX3_MA0714.2 6 bp overlap

Motif DE_72h DE_72h-PITX3_MA0714.2 6 bp overlap

POU2F1::SOX2 1 dataset

Motif DE_60h DE_60h-POU2F1SOX2_MA1962.1 17 bp overlap

POU5F1 1 dataset

ChIP HUES-8 GSE109524.POU5F1.HUES-8 363 bp overlap

PSIP1 1 dataset

ChIP T-REx-293 GSE117155.PSIP1.T-REx-293 182 bp overlap

Pou5f1::Sox2 1 dataset

Motif DE_60h DE_60h-Pou5f1Sox2_MA0142.1 15 bp overlap

RBPJ 3 datasets

Motif DE_48h DE_48h-RBPJ_MA1116.2 6 bp overlap

Motif DE_60h DE_60h-RBPJ_MA1116.2 6 bp overlap

Motif DE_72h DE_72h-RBPJ_MA1116.2 6 bp overlap

REL 1 dataset

Motif DE_60h DE_60h-REL_MA0101.1 10 bp overlap

RELA 1 dataset

ChIP aortic-endothelial-cell_IL1B_D7 GSE139377.RELA.aortic-endothelial-cell_IL1B_D7 303 bp overlap

RHOXF1 3 datasets

Motif DE_48h DE_48h-RHOXF1_MA0719.2 6 bp overlap

Motif DE_60h DE_60h-RHOXF1_MA0719.2 6 bp overlap

Motif DE_72h DE_72h-RHOXF1_MA0719.2 6 bp overlap

SIN3A 1 dataset

ChIP HUVEC-C GSE103245.SIN3A.HUVEC-C 217 bp overlap

SMAD2-3 1 dataset

ChIP HUES-8_DE GSE109524.SMAD2-3.HUES-8_DE 371 bp overlap

SMAD2_3 1 dataset

ChIP DE_D2 S01-DE-d2-SMAD2_3-exp1 227 bp overlap

SMAD3 1 dataset

ChIP BG03 GSE21614.SMAD3.BG03 190 bp overlap

SMARCA4 1 dataset

ChIP hiPSC GSE124903.SMARCA4.hiPSC 201 bp overlap

SOX10 2 datasets

Motif DE_48h DE_48h-SOX10_MA0442.3 6 bp overlap

Motif DE_60h DE_60h-SOX10_MA0442.3 6 bp overlap

SOX17 1 dataset

ChIP DE_D2 DED2-SOX17_Batch_II 278 bp overlap

SOX17_M 1 dataset

ChIP DE_D2 DED2-SOX17-M_Batch_II 440 bp overlap

SOX2 1 dataset

ChIP hiPSC GSE56567.SOX2.hiPSC 236 bp overlap

SOX4 2 datasets

Motif DE_48h DE_48h-SOX4_MA0867.3 8 bp overlap

Motif DE_60h DE_60h-SOX4_MA0867.3 8 bp overlap

Six3 1 dataset

Motif DE_60h DE_60h-Six3_MA0631.2 11 bp overlap

Sox6 2 datasets

Motif DE_48h DE_48h-Sox6_MA0515.1 10 bp overlap

Motif DE_60h DE_60h-Sox6_MA0515.1 10 bp overlap

Stat5a::Stat5b 3 datasets

Motif DE_48h DE_48h-Stat5aStat5b_MA0519.2 9 bp overlap

Motif DE_60h DE_60h-Stat5aStat5b_MA0519.2 9 bp overlap

Motif DE_72h DE_72h-Stat5aStat5b_MA0519.2 9 bp overlap

Stat5b 3 datasets

Motif DE_48h DE_48h-Stat5b_MA1625.2 9 bp overlap

Motif DE_60h DE_60h-Stat5b_MA1625.2 9 bp overlap

Motif DE_72h DE_72h-Stat5b_MA1625.2 9 bp overlap

TBX2 1 dataset

ChIP Kelly GSE94822.TBX2.Kelly 213 bp overlap

TFAP4::FLI1 1 dataset

Motif DE_60h DE_60h-TFAP4FLI1_MA1967.2 14 bp overlap

ZKSCAN5 2 datasets

Motif DE_48h DE_48h-ZKSCAN5_MA1652.2 9 bp overlap

Motif DE_60h DE_60h-ZKSCAN5_MA1652.2 9 bp overlap

ZNF281 2 datasets

Motif DE_48h DE_48h-ZNF281_MA1630.3 10 bp overlap

Motif DE_60h DE_60h-ZNF281_MA1630.3 10 bp overlap

ZNF343 2 datasets

Motif DE_48h DE_48h-ZNF343_MA1711.2 16 bp overlap

Motif DE_60h DE_60h-ZNF343_MA1711.2 16 bp overlap

ZNF75A 3 datasets

Motif DE_48h DE_48h-ZNF75A_MA2097.1 12 bp overlap

Motif DE_60h DE_60h-ZNF75A_MA2097.1 12 bp overlap

Motif DE_72h DE_72h-ZNF75A_MA2097.1 12 bp overlap

ZNF8 1 dataset

Motif DE_60h DE_60h-ZNF8_MA1718.1 20 bp overlap