chr5 : 35,317,354 – 35,318,124
770 bp 100 TFs 2 linked genes
This 770 bp open chromatin element is linked to PRLR and SPEF2 and is bound by 100 transcription factors.
Linked Genes
2 genes
Gene↕ Expression Dist. to TSS↑ Distance↕ Link type↕
PRLR 87.3 kb Distal Multiome
SPEF2 300.1 kb Distal Multiome
Chromatin Accessibility

Genome Browser

Genomic view centred on this element. Tracks include ATAC-seq accessibility, RNA-seq expression, TF binding peaks, and element-to-gene loop arcs across the ESC → DE time course.

View limited to ±500 kb around this element.
For the full data, please see the UCSC track linked below.
chr5:35,312,354 – 35,323,124
This element Other elements Gene links ATAC-seq RNA-seq

Transcription factors with ChIP-seq peak overlap or TOBIAS motif footprint evidence at this element.

TF Binding
100 transcription factors
Source
Cell type
ASCL1 3 datasets
Motif DE_48h DE_48h-ASCL1_MA1631.2 9 bp overlap
Motif DE_60h DE_60h-ASCL1_MA1631.2 9 bp overlap
Motif DE_72h DE_72h-ASCL1_MA1631.2 9 bp overlap
ATF7 1 dataset
ChIP GM12878 ENCSR014YCR.ATF7.GM12878 136 bp overlap
BRD3 1 dataset
ChIP H-1_DE GSE126661.BRD3.H-1_DE 272 bp overlap
BRD4 1 dataset
ChIP HCC1395 GSE63581.BRD4.HCC1395 98 bp overlap
CRY1 2 datasets
ChIP U2OS GSE130602.CRY1.U2OS 278 bp overlap
ChIP U2OS_DMSO GSE130506.CRY1.U2OS_DMSO 277 bp overlap
Cebpa 1 dataset
ChIP BLaER1 ENCFF896HSY 251 bp overlap
Crx 3 datasets
Motif DE_36h DE_36h-Crx_MA0467.3 6 bp overlap
Motif DE_48h DE_48h-Crx_MA0467.3 6 bp overlap
Motif DE_60h DE_60h-Crx_MA0467.3 6 bp overlap
DPF2 2 datasets
ChIP GM12878 ENCFF681AJV 75 bp overlap
ChIP GM12878 ENCSR509FWH.DPF2.GM12878 69 bp overlap
Dmbx1 3 datasets
Motif DE_36h DE_36h-Dmbx1_MA0883.2 10 bp overlap
Motif DE_48h DE_48h-Dmbx1_MA0883.2 10 bp overlap
Motif DE_60h DE_60h-Dmbx1_MA0883.2 10 bp overlap
E2F6 1 dataset
Motif DE_48h DE_48h-E2F6_MA0471.3 8 bp overlap
E2F8 1 dataset
Motif DE_48h DE_48h-E2F8_MA0865.3 9 bp overlap
ELF3 1 dataset
Motif DE_48h DE_48h-ELF3_MA0640.3 9 bp overlap
EOMES 1 dataset
ChIP hESC GSE26097.EOMES.hESC 337 bp overlap
ERF::FOXI1 3 datasets
Motif DE_36h DE_36h-ERFFOXI1_MA1935.2 10 bp overlap
Motif DE_48h DE_48h-ERFFOXI1_MA1935.2 10 bp overlap
Motif DE_60h DE_60h-ERFFOXI1_MA1935.2 10 bp overlap
ERF::FOXO1 3 datasets
Motif DE_36h DE_36h-ERFFOXO1_MA1936.2 12 bp overlap
Motif DE_48h DE_48h-ERFFOXO1_MA1936.2 12 bp overlap
Motif DE_60h DE_60h-ERFFOXO1_MA1936.2 12 bp overlap
ESR1 4 datasets
ChIP Ishikawa_C2-3 GSE147141.ESR1.Ishikawa_C2-3 60 bp overlap
ChIP Ishikawa_E2_D538G_clone2 GSE132426.ESR1.Ishikawa_E2_D538G_clone2 128 bp overlap
ChIP MCF-7_estradiol-Dex_4h GSE99626.ESR1.MCF-7_estradiol-Dex_4h 89 bp overlap
ChIP MCF-7_estradiol_4h GSE99626.ESR1.MCF-7_estradiol_4h 73 bp overlap
ETV1 3 datasets
Motif DE_36h DE_36h-ETV1_MA0761.3 9 bp overlap
Motif DE_48h DE_48h-ETV1_MA0761.3 9 bp overlap
Motif DE_60h DE_60h-ETV1_MA0761.3 9 bp overlap
ETV2::FOXI1 3 datasets
Motif DE_36h DE_36h-ETV2FOXI1_MA1942.2 11 bp overlap
Motif DE_48h DE_48h-ETV2FOXI1_MA1942.2 11 bp overlap
Motif DE_60h DE_60h-ETV2FOXI1_MA1942.2 11 bp overlap
ETV5::FOXI1 3 datasets
Motif DE_36h DE_36h-ETV5FOXI1_MA1946.2 12 bp overlap
Motif DE_48h DE_48h-ETV5FOXI1_MA1946.2 12 bp overlap
Motif DE_60h DE_60h-ETV5FOXI1_MA1946.2 12 bp overlap
ETV5::FOXO1 3 datasets
Motif DE_36h DE_36h-ETV5FOXO1_MA1947.2 10 bp overlap
Motif DE_48h DE_48h-ETV5FOXO1_MA1947.2 10 bp overlap
Motif DE_60h DE_60h-ETV5FOXO1_MA1947.2 10 bp overlap
FIGLA 3 datasets
Motif DE_48h DE_48h-FIGLA_MA0820.2 6 bp overlap
Motif DE_60h DE_60h-FIGLA_MA0820.2 6 bp overlap
Motif DE_72h DE_72h-FIGLA_MA0820.2 6 bp overlap
FOXA2 2 datasets
ChIP DE DE-FOXA2-1 346 bp overlap
ChIP DE DE-FOXA2-2 310 bp overlap
FOXJ2::ELF1 3 datasets
Motif DE_36h DE_36h-FOXJ2ELF1_MA1952.2 11 bp overlap
Motif DE_48h DE_48h-FOXJ2ELF1_MA1952.2 11 bp overlap
Motif DE_60h DE_60h-FOXJ2ELF1_MA1952.2 11 bp overlap
FOXO1::ELF1 3 datasets
Motif DE_36h DE_36h-FOXO1ELF1_MA1953.2 13 bp overlap
Motif DE_48h DE_48h-FOXO1ELF1_MA1953.2 13 bp overlap
Motif DE_60h DE_60h-FOXO1ELF1_MA1953.2 13 bp overlap
FOXO1::ELK1 3 datasets
Motif DE_36h DE_36h-FOXO1ELK1_MA1954.2 13 bp overlap
Motif DE_48h DE_48h-FOXO1ELK1_MA1954.2 13 bp overlap
Motif DE_60h DE_60h-FOXO1ELK1_MA1954.2 13 bp overlap
FOXO1::ELK3 3 datasets
Motif DE_36h DE_36h-FOXO1ELK3_MA1955.2 13 bp overlap
Motif DE_48h DE_48h-FOXO1ELK3_MA1955.2 13 bp overlap
Motif DE_60h DE_60h-FOXO1ELK3_MA1955.2 13 bp overlap
GATA4 2 datasets
ChIP DE DE-GATA4-1 528 bp overlap
ChIP DE DE-GATA4-2 770 bp overlap
GATA6 11 datasets
ChIP DE DE-GATA6-1 524 bp overlap
ChIP DE DE-GATA6-2 770 bp overlap
ChIP DE_D1 S09-DE-d1-GATA6-exp1 66 bp overlap
ChIP DE_D1 S09-DE-d1-GATA6-exp1 525 bp overlap
ChIP DE_D1 S14-DE-d1-GATA6-exp1 514 bp overlap
ChIP DE_D1 S41-DE-d1-GATA6-exp2 428 bp overlap
ChIP DE_D2 S55-DE-d2-GATA6-exp2 517 bp overlap
ChIP HUES-8_DE_JNKi GSE109524.GATA6.HUES-8_DE_JNKi 649 bp overlap
ChIP HUES-8_DE_ctrl GSE109524.GATA6.HUES-8_DE_ctrl 57 bp overlap
ChIP HUES-8_DE_ctrl GSE109524.GATA6.HUES-8_DE_ctrl 525 bp overlap
ChIP endoderm_KO GSE117136.GATA6.endoderm_KO 343 bp overlap
GSC 3 datasets
Motif DE_36h DE_36h-GSC_MA0648.2 6 bp overlap
Motif DE_48h DE_48h-GSC_MA0648.2 6 bp overlap
Motif DE_60h DE_60h-GSC_MA0648.2 6 bp overlap
GSC2 3 datasets
Motif DE_36h DE_36h-GSC2_MA0891.2 6 bp overlap
Motif DE_48h DE_48h-GSC2_MA0891.2 6 bp overlap
Motif DE_60h DE_60h-GSC2_MA0891.2 6 bp overlap
HNRNPK 2 datasets
ChIP Hep-G2 ENCSR519QAA.HNRNPK.Hep-G2 193 bp overlap
ChIP Hep-G2 GSE120104.HNRNPK.Hep-G2 325 bp overlap
Hnf1A 3 datasets
Motif DE_48h DE_48h-Hnf1A_MA1991.2 10 bp overlap
Motif DE_60h DE_60h-Hnf1A_MA1991.2 10 bp overlap
Motif DE_72h DE_72h-Hnf1A_MA1991.2 10 bp overlap
IKZF1 3 datasets
Motif DE_36h DE_36h-IKZF1_MA1508.2 8 bp overlap
Motif DE_48h DE_48h-IKZF1_MA1508.2 8 bp overlap
Motif DE_60h DE_60h-IKZF1_MA1508.2 8 bp overlap
IKZF2 5 datasets
Motif DE_36h DE_36h-IKZF2_MA2326.1 6 bp overlap
Motif DE_48h DE_48h-IKZF2_MA2326.1 6 bp overlap
Motif DE_60h DE_60h-IKZF2_MA2326.1 6 bp overlap
ChIP GM12878 ENCFF238LYK 116 bp overlap
ChIP GM12878 ENCFF918AID 53 bp overlap
Ikzf3 1 dataset
Motif DE_48h DE_48h-Ikzf3_MA1992.2 9 bp overlap
JUN 3 datasets
ChIP DE_D1 S40-DE-d1-JUN-exp2 68 bp overlap
ChIP DE_D2 S02-DE-d2-JUN-exp1 409 bp overlap
ChIP HUES-8_DE_ctrl GSE109524.JUN.HUES-8_DE_ctrl 64 bp overlap
KLF1 1 dataset
Motif DE_48h DE_48h-KLF1_MA0493.3 8 bp overlap
KLF2 1 dataset
Motif DE_48h DE_48h-KLF2_MA1515.2 8 bp overlap
KLF4 1 dataset
Motif DE_48h DE_48h-KLF4_MA0039.5 8 bp overlap
KLF5 2 datasets
Motif DE_48h DE_48h-KLF5_MA0599.1 10 bp overlap
Motif DE_48h DE_48h-KLF5_MA0599.1 10 bp overlap
Lef1 3 datasets
Motif DE_48h DE_48h-Lef1_MA0768.3 8 bp overlap
Motif DE_60h DE_60h-Lef1_MA0768.3 8 bp overlap
Motif DE_72h DE_72h-Lef1_MA0768.3 8 bp overlap
MSANTD3 3 datasets
Motif DE_36h DE_36h-MSANTD3_MA1523.2 7 bp overlap
Motif DE_48h DE_48h-MSANTD3_MA1523.2 7 bp overlap
Motif DE_60h DE_60h-MSANTD3_MA1523.2 7 bp overlap
MTA2 1 dataset
ChIP GM12878 ENCSR293QAR.MTA2.GM12878 231 bp overlap
MXI1 2 datasets
Motif DE_48h DE_48h-MXI1_MA1108.3 6 bp overlap
Motif DE_60h DE_60h-MXI1_MA1108.3 6 bp overlap
MYOD1 3 datasets
ChIP RD GSE137168.MYOD1.RD 208 bp overlap
ChIP RH4 GSE83726.MYOD1.RH4 202 bp overlap
ChIP rhabdomyosarcoma GSE50413.MYOD1.rhabdomyosarcoma 156 bp overlap
MZF1 3 datasets
Motif DE_36h DE_36h-MZF1_MA0056.3 8 bp overlap
Motif DE_48h DE_48h-MZF1_MA0056.3 8 bp overlap
Motif DE_60h DE_60h-MZF1_MA0056.3 8 bp overlap
Mafb 3 datasets
Motif DE_48h DE_48h-Mafb_MA0117.3 11 bp overlap
Motif DE_60h DE_60h-Mafb_MA0117.3 11 bp overlap
Motif DE_72h DE_72h-Mafb_MA0117.3 11 bp overlap
NANOG 1 dataset
ChIP WA01_3IL ERP004238.NANOG.WA01_3IL 337 bp overlap
NRL 3 datasets
Motif DE_48h DE_48h-NRL_MA0842.3 12 bp overlap
Motif DE_60h DE_60h-NRL_MA0842.3 12 bp overlap
Motif DE_72h DE_72h-NRL_MA0842.3 12 bp overlap
Nr2F6 1 dataset
Motif DE_48h DE_48h-Nr2F6_MA0728.1 15 bp overlap
OTX1 3 datasets
Motif DE_36h DE_36h-OTX1_MA0711.2 6 bp overlap
Motif DE_48h DE_48h-OTX1_MA0711.2 6 bp overlap
Motif DE_60h DE_60h-OTX1_MA0711.2 6 bp overlap
OTX2 3 datasets
Motif DE_36h DE_36h-OTX2_MA0712.3 7 bp overlap
Motif DE_48h DE_48h-OTX2_MA0712.3 7 bp overlap
Motif DE_60h DE_60h-OTX2_MA0712.3 7 bp overlap
PAX3-FOXO1 2 datasets
ChIP Hs-352-Sk_PAX3-FOXO1-vector GSE83725.PAX3-FOXO1.Hs-352-Sk_PAX3-FOXO1-vector 241 bp overlap
ChIP RH4 GSE140115.PAX3-FOXO1.RH4 166 bp overlap
PITX1 3 datasets
Motif DE_36h DE_36h-PITX1_MA0682.3 6 bp overlap
Motif DE_48h DE_48h-PITX1_MA0682.3 6 bp overlap
Motif DE_60h DE_60h-PITX1_MA0682.3 6 bp overlap
PITX3 3 datasets
Motif DE_36h DE_36h-PITX3_MA0714.2 6 bp overlap
Motif DE_48h DE_48h-PITX3_MA0714.2 6 bp overlap
Motif DE_60h DE_60h-PITX3_MA0714.2 6 bp overlap
RARA 1 dataset
Motif DE_48h DE_48h-RARA_MA0729.1 18 bp overlap
RELA 1 dataset
ChIP FaDu_LPS GSE132018.RELA.FaDu_LPS 203 bp overlap
RHOXF1 3 datasets
Motif DE_36h DE_36h-RHOXF1_MA0719.2 6 bp overlap
Motif DE_48h DE_48h-RHOXF1_MA0719.2 6 bp overlap
Motif DE_60h DE_60h-RHOXF1_MA0719.2 6 bp overlap
SATB1 2 datasets
ChIP MCF-10A_ICRF GSE123292.SATB1.MCF-10A_ICRF 151 bp overlap
ChIP MCF-10A_dHD GSE123292.SATB1.MCF-10A_dHD 184 bp overlap
SKIL 1 dataset
ChIP GM12878 ENCSR212YKD.SKIL.GM12878 115 bp overlap
SMAD2 1 dataset
ChIP endoderm GSE29422.SMAD2.endoderm 242 bp overlap
SMAD2-3 4 datasets
ChIP HUES-8_DE GSE109524.SMAD2-3.HUES-8_DE 638 bp overlap
ChIP HUES-8_DE_JNKi GSE109524.SMAD2-3.HUES-8_DE_JNKi 565 bp overlap
ChIP HUES-8_DE_ctrl GSE109524.SMAD2-3.HUES-8_DE_ctrl 226 bp overlap
ChIP HUES-8_DE_ctrl GSE109524.SMAD2-3.HUES-8_DE_ctrl 277 bp overlap
SMAD2_3 7 datasets
ChIP DE_D1 S07-DE-d1-SMAD2_3-exp1 60 bp overlap
ChIP DE_D1 S07-DE-d1-SMAD2_3-exp1 272 bp overlap
ChIP DE_D1 S12-DE-d1-SMAD2_3-exp1 511 bp overlap
ChIP DE_D1 S39-DE-d1-SMAD2_3-exp2 70 bp overlap
ChIP DE_D2 S01-DE-d2-SMAD2_3-exp1 623 bp overlap
ChIP DE_D2 S53-DE-d2-SMAD2_3-exp2 75 bp overlap
ChIP DE_D2 S53-DE-d2-SMAD2_3-exp2 519 bp overlap
SMAD3 7 datasets
ChIP BG03_DIFF_48H GSE36578.SMAD3.BG03_DIFF_48H 235 bp overlap
ChIP HCC1954 GSE104760.SMAD3.HCC1954 71 bp overlap
ChIP HCC1954_TGFb GSE104760.SMAD3.HCC1954_TGFb 273 bp overlap
ChIP HMLE_Doxycicline_TGFb GSE104760.SMAD3.HMLE_Doxycicline_TGFb 60 bp overlap
ChIP NCI-H441 GSE51509.SMAD3.NCI-H441 404 bp overlap
ChIP NCI-H441_SIITTF1 GSE51509.SMAD3.NCI-H441_SIITTF1 383 bp overlap
ChIP endoderm GSE29422.SMAD3.endoderm 217 bp overlap
SMAD4 1 dataset
ChIP endoderm GSE29422.SMAD4.endoderm 220 bp overlap
SNAI1 3 datasets
Motif DE_48h DE_48h-SNAI1_MA1558.2 7 bp overlap
Motif DE_60h DE_60h-SNAI1_MA1558.2 7 bp overlap
Motif DE_72h DE_72h-SNAI1_MA1558.2 7 bp overlap
SNAI2 1 dataset
ChIP RD GSE137168.SNAI2.RD 219 bp overlap
SOX17 1 dataset
ChIP DE_D2 DED2-SOX17_Batch_II 431 bp overlap
SOX17_M 1 dataset
ChIP DE_D2 DED2-SOX17-M_Batch_II 550 bp overlap
SP5 3 datasets
Motif DE_48h DE_48h-SP5_MA1965.2 6 bp overlap
Motif DE_48h DE_48h-SP5_MA1965.2 6 bp overlap
Motif DE_60h DE_60h-SP5_MA1965.2 6 bp overlap
SREBF2 1 dataset
Motif DE_48h DE_48h-SREBF2_MA0596.1 10 bp overlap
Spz1 1 dataset
Motif DE_48h DE_48h-Spz1_MA0111.1 11 bp overlap
TBX21 1 dataset
ChIP GM12878 ENCSR739IHN.TBX21.GM12878 269 bp overlap
TCF12 3 datasets
Motif DE_48h DE_48h-TCF12_MA1648.2 7 bp overlap
Motif DE_60h DE_60h-TCF12_MA1648.2 7 bp overlap
Motif DE_72h DE_72h-TCF12_MA1648.2 7 bp overlap
TCF3 3 datasets
Motif DE_48h DE_48h-TCF3_MA0522.4 7 bp overlap
Motif DE_60h DE_60h-TCF3_MA0522.4 7 bp overlap
Motif DE_72h DE_72h-TCF3_MA0522.4 7 bp overlap
TCF4 3 datasets
Motif DE_48h DE_48h-TCF4_MA0830.3 8 bp overlap
Motif DE_60h DE_60h-TCF4_MA0830.3 8 bp overlap
Motif DE_72h DE_72h-TCF4_MA0830.3 8 bp overlap
TCF7 3 datasets
Motif DE_48h DE_48h-TCF7_MA0769.3 7 bp overlap
Motif DE_60h DE_60h-TCF7_MA0769.3 7 bp overlap
Motif DE_72h DE_72h-TCF7_MA0769.3 7 bp overlap
Tbx6 1 dataset
Motif DE_48h DE_48h-Tbx6_MA1567.3 9 bp overlap
ZBTB24 1 dataset
Motif DE_48h DE_48h-ZBTB24_MA2330.1 10 bp overlap
ZEB1 3 datasets
Motif DE_48h DE_48h-ZEB1_MA0103.4 6 bp overlap
Motif DE_60h DE_60h-ZEB1_MA0103.4 6 bp overlap
Motif DE_72h DE_72h-ZEB1_MA0103.4 6 bp overlap
ZNF143 1 dataset
ChIP FLP143HA_T4 GSE39263.ZNF143.FLP143HA_T4 145 bp overlap
ZNF157 3 datasets
Motif DE_48h DE_48h-ZNF157_MA2331.1 21 bp overlap
Motif DE_60h DE_60h-ZNF157_MA2331.1 21 bp overlap
Motif DE_72h DE_72h-ZNF157_MA2331.1 21 bp overlap
ZNF175 3 datasets
Motif DE_36h DE_36h-ZNF175_MA2332.1 9 bp overlap
Motif DE_48h DE_48h-ZNF175_MA2332.1 9 bp overlap
Motif DE_60h DE_60h-ZNF175_MA2332.1 9 bp overlap
ZNF189 6 datasets
Motif DE_36h DE_36h-ZNF189_MA1725.2 9 bp overlap
Motif DE_48h DE_48h-ZNF189_MA1725.2 9 bp overlap
Motif DE_48h DE_48h-ZNF189_MA1725.2 9 bp overlap
Motif DE_60h DE_60h-ZNF189_MA1725.2 9 bp overlap
Motif DE_60h DE_60h-ZNF189_MA1725.2 9 bp overlap
Motif DE_72h DE_72h-ZNF189_MA1725.2 9 bp overlap
ZNF19 1 dataset
ChIP HEK293T GSE78099.ZNF19.HEK293T 333 bp overlap
ZNF24 3 datasets
Motif DE_36h DE_36h-ZNF24_MA1124.1 13 bp overlap
Motif DE_48h DE_48h-ZNF24_MA1124.1 13 bp overlap
Motif DE_60h DE_60h-ZNF24_MA1124.1 13 bp overlap
ZNF274 3 datasets
Motif DE_36h DE_36h-ZNF274_MA1592.2 12 bp overlap
Motif DE_48h DE_48h-ZNF274_MA1592.2 12 bp overlap
Motif DE_60h DE_60h-ZNF274_MA1592.2 12 bp overlap
ZNF317 3 datasets
Motif DE_48h DE_48h-ZNF317_MA1593.2 8 bp overlap
Motif DE_60h DE_60h-ZNF317_MA1593.2 8 bp overlap
Motif DE_72h DE_72h-ZNF317_MA1593.2 8 bp overlap
ZNF341 3 datasets
Motif DE_36h DE_36h-ZNF341_MA1655.2 8 bp overlap
Motif DE_48h DE_48h-ZNF341_MA1655.2 8 bp overlap
Motif DE_60h DE_60h-ZNF341_MA1655.2 8 bp overlap
ZNF549 1 dataset
Motif DE_48h DE_48h-ZNF549_MA1728.2 8 bp overlap
ZNF677 3 datasets
Motif DE_36h DE_36h-ZNF677_MA2101.1 12 bp overlap
Motif DE_48h DE_48h-ZNF677_MA2101.1 12 bp overlap
Motif DE_60h DE_60h-ZNF677_MA2101.1 12 bp overlap
ZNF687 1 dataset
ChIP GM12878 ENCFF233SGE 457 bp overlap
ZNF701 3 datasets
Motif DE_36h DE_36h-ZNF701_MA1987.2 17 bp overlap
Motif DE_48h DE_48h-ZNF701_MA1987.2 17 bp overlap
Motif DE_60h DE_60h-ZNF701_MA1987.2 17 bp overlap
ZNF816 1 dataset
Motif DE_48h DE_48h-ZNF816_MA1719.2 15 bp overlap
Zic1::Zic2 3 datasets
Motif DE_36h DE_36h-Zic1Zic2_MA1628.2 7 bp overlap
Motif DE_48h DE_48h-Zic1Zic2_MA1628.2 7 bp overlap
Motif DE_60h DE_60h-Zic1Zic2_MA1628.2 7 bp overlap
Zic2 3 datasets
Motif DE_36h DE_36h-Zic2_MA1629.2 9 bp overlap
Motif DE_48h DE_48h-Zic2_MA1629.2 9 bp overlap
Motif DE_60h DE_60h-Zic2_MA1629.2 9 bp overlap
Zic3 3 datasets
Motif DE_36h DE_36h-Zic3_MA0697.3 7 bp overlap
Motif DE_48h DE_48h-Zic3_MA0697.3 7 bp overlap
Motif DE_60h DE_60h-Zic3_MA0697.3 7 bp overlap