chr7 : 140,278,313 – 140,279,187

874 bp 65 TFs 3 linked genes

This 874 bp open chromatin element is linked to KDM7A, SLC37A3, and MKRN1 and is bound by 65 transcription factors.

Linked Genes

3 genes

Gene	Dist. to TSS	Distance	Link type
KDM7A	101.8 kb	Distal	Multiome
SLC37A3	119.7 kb	Distal	Multiome
MKRN1	200.7 kb	Distal	Multiome

Chromatin Accessibility

Genome Browser

Genomic view centred on this element. Tracks include ATAC-seq accessibility, RNA-seq expression, TF binding peaks, and element-to-gene loop arcs across the ESC → DE time course.

Transcription factors with ChIP-seq peak overlap or TOBIAS motif footprint evidence at this element.

TF Binding

65 transcription factors

ATF2 1 dataset

Motif DE_60h DE_60h-ATF2_MA1632.2 10 bp overlap

ATF4 1 dataset

Motif DE_60h DE_60h-ATF4_MA0833.3 10 bp overlap

DMRTA2 1 dataset

Motif DE_72h DE_72h-DMRTA2_MA1478.2 6 bp overlap

DUX4 4 datasets

Motif DE_60h DE_60h-DUX4_MA0468.1 11 bp overlap

ChIP HEK293 GSE75791.DUX4.HEK293 319 bp overlap

ChIP WA01 GSE94322.DUX4.WA01 403 bp overlap

DUXA 1 dataset

Motif DE_60h DE_60h-DUXA_MA0884.2 13 bp overlap

Dux 4 datasets

Motif DE_60h DE_60h-Dux_MA0611.3 11 bp overlap

Motif DE_72h DE_72h-Dux_MA0611.3 11 bp overlap

EOMES 1 dataset

ChIP hESC GSE26097.EOMES.hESC 334 bp overlap

FOS::JUN 1 dataset

Motif DE_60h DE_60h-FOSJUN_MA1126.2 10 bp overlap

FOSB::JUN 1 dataset

Motif DE_60h DE_60h-FOSBJUN_MA1127.1 11 bp overlap

FOXA2 2 datasets

ChIP DE DE-FOXA2-1 616 bp overlap

ChIP DE DE-FOXA2-2 652 bp overlap

FOXE1 1 dataset

Motif DE_60h DE_60h-FOXE1_MA1487.3 12 bp overlap

FOXN3 1 dataset

Motif DE_60h DE_60h-FOXN3_MA1489.1 8 bp overlap

GATA1 2 datasets

Motif DE_72h DE_72h-GATA1_MA0035.5 7 bp overlap

ChIP K-562 GSE107726.GATA1.K-562 273 bp overlap

GATA1::TAL1 1 dataset

Motif DE_72h DE_72h-GATA1TAL1_MA0140.3 17 bp overlap

GATA2 1 dataset

ChIP TF1 GSE73207.GATA2.TF1 169 bp overlap

GATA3 3 datasets

ChIP MCF-7 GSE122847.GATA3.MCF-7 206 bp overlap

ChIP MCF-7 GSE133072.GATA3.MCF-7 180 bp overlap

ChIP MCF-7_sgScr GSE133072.GATA3.MCF-7_sgScr 237 bp overlap

GATA4 3 datasets

ChIP DE DE-GATA4-1 747 bp overlap

ChIP DE DE-GATA4-2 870 bp overlap

ChIP foregut GSE117136.GATA4.foregut 604 bp overlap

GATA6 6 datasets

ChIP DE DE-GATA6-1 671 bp overlap

ChIP DE DE-GATA6-2 759 bp overlap

ChIP DE_D2 S55-DE-d2-GATA6-exp2 682 bp overlap

ChIP endoderm_KO GSE117136.GATA6.endoderm_KO 407 bp overlap

ChIP foregut GSE117136.GATA6.foregut 574 bp overlap

ChIP foregut_KO GSE117136.GATA6.foregut_KO 302 bp overlap

Gfi1B 1 dataset

Motif DE_72h DE_72h-Gfi1B_MA0483.2 10 bp overlap

HMBOX1 1 dataset

Motif DE_72h DE_72h-HMBOX1_MA0895.2 7 bp overlap

JUN 2 datasets

Motif DE_60h DE_60h-JUN_MA0488.2 10 bp overlap

ChIP DE_D2 S02-DE-d2-JUN-exp1 275 bp overlap

LHX6 1 dataset

Motif DE_60h DE_60h-LHX6_MA0658.2 8 bp overlap

MEIS1 1 dataset

Motif DE_72h DE_72h-MEIS1_MA0498.3 5 bp overlap

MYB 1 dataset

Motif DE_72h DE_72h-MYB_MA0100.4 6 bp overlap

Mecom 1 dataset

Motif DE_72h DE_72h-Mecom_MA0029.2 11 bp overlap

NEUROG2 1 dataset

Motif DE_60h DE_60h-NEUROG2_MA1642.2 7 bp overlap

NKX2-4 1 dataset

Motif DE_72h DE_72h-NKX2-4_MA2003.2 8 bp overlap

NRL 1 dataset

Motif DE_60h DE_60h-NRL_MA0842.3 12 bp overlap

PAX3 1 dataset

Motif DE_72h DE_72h-PAX3_MA1546.2 14 bp overlap

PAX5 1 dataset

Motif DE_72h DE_72h-PAX5_MA0014.4 8 bp overlap

PHOX2A 1 dataset

Motif DE_60h DE_60h-PHOX2A_MA0713.1 11 bp overlap

PHOX2B 2 datasets

Motif DE_60h DE_60h-PHOX2B_MA0681.3 12 bp overlap

POU1F1 1 dataset

Motif DE_60h DE_60h-POU1F1_MA0784.3 14 bp overlap

POU3F3 1 dataset

Motif DE_60h DE_60h-POU3F3_MA0788.1 13 bp overlap

PRDM1 2 datasets

Motif DE_60h DE_60h-PRDM1_MA0508.4 7 bp overlap

Motif DE_72h DE_72h-PRDM1_MA0508.4 7 bp overlap

PRDM9 1 dataset

Motif DE_72h DE_72h-PRDM9_MA1723.2 20 bp overlap

PROP1 1 dataset

Motif DE_60h DE_60h-PROP1_MA0715.1 11 bp overlap

Ptf1A 1 dataset

Motif DE_60h DE_60h-Ptf1A_MA1618.2 9 bp overlap

RARA 1 dataset

Motif DE_72h DE_72h-RARA_MA0729.1 18 bp overlap

Rarb 1 dataset

Motif DE_72h DE_72h-Rarb_MA0857.1 16 bp overlap

Rarg 1 dataset

Motif DE_72h DE_72h-Rarg_MA0859.2 15 bp overlap

Rfx6 1 dataset

Motif DE_72h DE_72h-Rfx6_MA1724.2 9 bp overlap

SMAD2-3 1 dataset

ChIP HUES-8_DE GSE109524.SMAD2-3.HUES-8_DE 373 bp overlap

SMAD2_3 2 datasets

ChIP DE_D2 S01-DE-d2-SMAD2_3-exp1 399 bp overlap

ChIP DE_D2 S53-DE-d2-SMAD2_3-exp2 364 bp overlap

SOX13 2 datasets

Motif DE_72h DE_72h-SOX13_MA1120.2 7 bp overlap

SOX17 1 dataset

ChIP DE_D2 DED2-SOX17_Batch_II 485 bp overlap

SOX17_M 1 dataset

ChIP DE_D2 DED2-SOX17-M_Batch_II 697 bp overlap

SOX2 2 datasets

Motif DE_72h DE_72h-SOX2_MA0143.5 7 bp overlap

SOX21 1 dataset

Motif DE_72h DE_72h-SOX21_MA0866.1 15 bp overlap

SP5 2 datasets

Motif DE_72h DE_72h-SP5_MA1965.2 6 bp overlap

Sox3 2 datasets

Motif DE_72h DE_72h-Sox3_MA0514.3 7 bp overlap

Sox5 1 dataset

Motif DE_72h DE_72h-Sox5_MA0087.3 8 bp overlap

Stat2 2 datasets

Motif DE_60h DE_60h-Stat2_MA1623.2 10 bp overlap

Motif DE_72h DE_72h-Stat2_MA1623.2 10 bp overlap

Stat6 1 dataset

Motif DE_72h DE_72h-Stat6_MA0520.2 10 bp overlap

TRPS1 1 dataset

ChIP T-47D GSE107013.TRPS1.T-47D 114 bp overlap

ZKSCAN5 1 dataset

Motif DE_72h DE_72h-ZKSCAN5_MA1652.2 9 bp overlap

ZNF189 1 dataset

Motif DE_72h DE_72h-ZNF189_MA1725.2 9 bp overlap

ZNF263 1 dataset

Motif DE_72h DE_72h-ZNF263_MA0528.3 7 bp overlap

ZNF316 2 datasets

ChIP K-562 ENCSR200JYP.ZNF316.K-562 283 bp overlap

ChIP K562 ENCFF281INV 130 bp overlap

ZNF320 1 dataset

Motif DE_72h DE_72h-ZNF320_MA1976.2 20 bp overlap

ZNF354A 1 dataset

Motif DE_60h DE_60h-ZNF354A_MA1978.2 20 bp overlap

ZNF382 1 dataset

Motif DE_72h DE_72h-ZNF382_MA1594.1 24 bp overlap

ZNF530 2 datasets

Motif DE_60h DE_60h-ZNF530_MA1981.2 14 bp overlap

Motif DE_72h DE_72h-ZNF530_MA1981.2 14 bp overlap

ZNF692 1 dataset

Motif DE_60h DE_60h-ZNF692_MA1986.2 8 bp overlap

ZNF85 1 dataset

Motif DE_60h DE_60h-ZNF85_MA1720.2 12 bp overlap