chr1 : 167,148,291 – 167,148,891
600 bp 99 TFs 3 linked genes
This 600 bp open chromatin element is linked to GPA33, POU2F1, and TADA1 and is bound by 99 transcription factors.
Linked Genes
3 genes
Gene↕ Expression Dist. to TSS↑ Distance↕ Link type↕
GPA33 17.9 kb Distal Multiome
POU2F1 72.3 kb Distal Multiome
TADA1 272.3 kb Distal Multiome
Chromatin Accessibility

Genome Browser

Genomic view centred on this element. Tracks include ATAC-seq accessibility, RNA-seq expression, TF binding peaks, and element-to-gene loop arcs across the ESC → DE time course.

View limited to ±500 kb around this element.
For the full data, please see the UCSC track linked below.
chr1:167,143,291 – 167,153,891
This element Other elements Gene links ATAC-seq RNA-seq

Transcription factors with ChIP-seq peak overlap or TOBIAS motif footprint evidence at this element.

TF Binding
99 transcription factors
Source
Cell type
AR 1 dataset
ChIP breast-cancer_ENOB-2854 GSE128018.AR.breast-cancer_ENOB-2854 228 bp overlap
ASH2L 2 datasets
ChIP H1 ENCFF399KAM 600 bp overlap
ChIP WA01 ENCSR850KIP.ASH2L.WA01 493 bp overlap
ATF2 1 dataset
ChIP WA01 ENCSR000BQU.ATF2.WA01 144 bp overlap
Ascl2 3 datasets
Motif DE_48h DE_48h-Ascl2_MA0816.1 10 bp overlap
Motif DE_60h DE_60h-Ascl2_MA0816.1 10 bp overlap
Motif DE_72h DE_72h-Ascl2_MA0816.1 10 bp overlap
BHLHE22 6 datasets
Motif DE_48h DE_48h-BHLHE22_MA1635.2 6 bp overlap
Motif DE_48h DE_48h-BHLHE22_MA1635.2 6 bp overlap
Motif DE_60h DE_60h-BHLHE22_MA1635.2 6 bp overlap
Motif DE_60h DE_60h-BHLHE22_MA1635.2 6 bp overlap
Motif DE_72h DE_72h-BHLHE22_MA1635.2 6 bp overlap
Motif DE_72h DE_72h-BHLHE22_MA1635.2 6 bp overlap
BRD4 2 datasets
ChIP SUM159PT_100nMtrametinib_24h GSE87418.BRD4.SUM159PT_100nMtrametinib_24h 568 bp overlap
ChIP SUM159PT_100nMtrametinib_72h GSE87418.BRD4.SUM159PT_100nMtrametinib_72h 402 bp overlap
CHD7 1 dataset
ChIP hiPSC_derived_lt-NES GSE108506.CHD7.hiPSC_derived_lt-NES 376 bp overlap
CTCFL 3 datasets
Motif DE_48h DE_48h-CTCFL_MA1102.3 8 bp overlap
Motif DE_60h DE_60h-CTCFL_MA1102.3 8 bp overlap
Motif DE_72h DE_72h-CTCFL_MA1102.3 8 bp overlap
Crx 3 datasets
Motif DE_48h DE_48h-Crx_MA0467.3 6 bp overlap
Motif DE_60h DE_60h-Crx_MA0467.3 6 bp overlap
Motif DE_72h DE_72h-Crx_MA0467.3 6 bp overlap
DUX4 3 datasets
Motif DE_48h DE_48h-DUX4_MA0468.1 11 bp overlap
Motif DE_60h DE_60h-DUX4_MA0468.1 11 bp overlap
Motif DE_72h DE_72h-DUX4_MA0468.1 11 bp overlap
EOMES 1 dataset
ChIP hESC GSE26097.EOMES.hESC 241 bp overlap
EP300 1 dataset
ChIP WA01 ENCSR000BKK.EP300.WA01 245 bp overlap
FOXA2 1 dataset
ChIP DE DE-FOXA2-1 313 bp overlap
FOXP1 1 dataset
ChIP H9 GSE31006.FOXP1.H9 159 bp overlap
GATA2 1 dataset
ChIP SH-SY5Y ENCSR000EYB.GATA2.SH-SY5Y 191 bp overlap
GATA4 3 datasets
ChIP DE DE-GATA4-1 378 bp overlap
ChIP DE DE-GATA4-2 412 bp overlap
ChIP foregut GSE117136.GATA4.foregut 259 bp overlap
GATA6 4 datasets
ChIP DE DE-GATA6-1 307 bp overlap
ChIP DE DE-GATA6-2 429 bp overlap
ChIP DE_D2 S55-DE-d2-GATA6-exp2 523 bp overlap
ChIP endoderm_KO GSE117136.GATA6.endoderm_KO 410 bp overlap
GFI1 3 datasets
Motif DE_48h DE_48h-GFI1_MA0038.3 11 bp overlap
Motif DE_60h DE_60h-GFI1_MA0038.3 11 bp overlap
Motif DE_72h DE_72h-GFI1_MA0038.3 11 bp overlap
GSC 3 datasets
Motif DE_48h DE_48h-GSC_MA0648.2 6 bp overlap
Motif DE_60h DE_60h-GSC_MA0648.2 6 bp overlap
Motif DE_72h DE_72h-GSC_MA0648.2 6 bp overlap
GSC2 3 datasets
Motif DE_48h DE_48h-GSC2_MA0891.2 6 bp overlap
Motif DE_60h DE_60h-GSC2_MA0891.2 6 bp overlap
Motif DE_72h DE_72h-GSC2_MA0891.2 6 bp overlap
HDAC2 1 dataset
ChIP WA01 ENCSR000BNR.HDAC2.WA01 209 bp overlap
HIC2 2 datasets
Motif DE_48h DE_48h-HIC2_MA0738.2 6 bp overlap
Motif DE_72h DE_72h-HIC2_MA0738.2 6 bp overlap
JUN 1 dataset
ChIP DE_D2 S02-DE-d2-JUN-exp1 303 bp overlap
JUND 1 dataset
ChIP WA01 ENCSR000BKP.JUND.WA01 117 bp overlap
MAX 1 dataset
ChIP WA01 ENCSR000EUP.MAX.WA01 138 bp overlap
MAZ 2 datasets
Motif DE_48h DE_48h-MAZ_MA1522.2 8 bp overlap
Motif DE_72h DE_72h-MAZ_MA1522.2 8 bp overlap
MSC 3 datasets
Motif DE_48h DE_48h-MSC_MA0665.1 10 bp overlap
Motif DE_60h DE_60h-MSC_MA0665.1 10 bp overlap
Motif DE_72h DE_72h-MSC_MA0665.1 10 bp overlap
MYBL2 1 dataset
ChIP A-673 GSE119971.MYBL2.A-673 230 bp overlap
MYOD1 2 datasets
ChIP RH30_DMSO GSE85169.MYOD1.RH30_DMSO 317 bp overlap
ChIP rhabdomyosarcoma GSE50413.MYOD1.rhabdomyosarcoma 111 bp overlap
MYOG 6 datasets
Motif DE_48h DE_48h-MYOG_MA0500.3 8 bp overlap
Motif DE_48h DE_48h-MYOG_MA0500.3 8 bp overlap
Motif DE_60h DE_60h-MYOG_MA0500.3 8 bp overlap
Motif DE_60h DE_60h-MYOG_MA0500.3 8 bp overlap
Motif DE_72h DE_72h-MYOG_MA0500.3 8 bp overlap
Motif DE_72h DE_72h-MYOG_MA0500.3 8 bp overlap
NANOG 5 datasets
ChIP HUES-8 GSE109524.NANOG.HUES-8 301 bp overlap
ChIP WA01 ENCSR000BMT.NANOG.WA01 210 bp overlap
ChIP WA01_3IL ERP004238.NANOG.WA01_3IL 260 bp overlap
ChIP WA09 GSE105028.NANOG.WA09 204 bp overlap
ChIP hESC GSE18292.NANOG.hESC 93 bp overlap
NCOR1 1 dataset
ChIP LS180_125 GSE39277.NCOR1.LS180_125 101 bp overlap
NEUROD1 1 dataset
ChIP D341-Med_shGFP GSE92582.NEUROD1.D341-Med_shGFP 183 bp overlap
NEUROG2 1 dataset
ChIP MRC-5_N_1DPT GSE75910.NEUROG2.MRC-5_N_1DPT 273 bp overlap
NFATC3 1 dataset
Motif DE_72h DE_72h-NFATC3_MA0625.3 6 bp overlap
NFYA 3 datasets
Motif DE_48h DE_48h-NFYA_MA0060.4 8 bp overlap
Motif DE_60h DE_60h-NFYA_MA0060.4 8 bp overlap
Motif DE_72h DE_72h-NFYA_MA0060.4 8 bp overlap
NFYC 3 datasets
Motif DE_48h DE_48h-NFYC_MA1644.2 7 bp overlap
Motif DE_60h DE_60h-NFYC_MA1644.2 7 bp overlap
Motif DE_72h DE_72h-NFYC_MA1644.2 7 bp overlap
NKX2-1 1 dataset
ChIP H9_derived-cIN GSE99937.NKX2-1.H9_derived-cIN 54 bp overlap
NR2C2 2 datasets
Motif DE_48h DE_48h-NR2C2_MA0504.2 14 bp overlap
Motif DE_72h DE_72h-NR2C2_MA0504.2 14 bp overlap
NR2F1 3 datasets
Motif DE_48h DE_48h-NR2F1_MA1538.1 15 bp overlap
Motif DE_60h DE_60h-NR2F1_MA1538.1 15 bp overlap
Motif DE_72h DE_72h-NR2F1_MA1538.1 15 bp overlap
NR2F6 3 datasets
Motif DE_48h DE_48h-NR2F6_MA1539.1 15 bp overlap
Motif DE_60h DE_60h-NR2F6_MA1539.1 15 bp overlap
Motif DE_72h DE_72h-NR2F6_MA1539.1 15 bp overlap
Neurod2 6 datasets
Motif DE_48h DE_48h-Neurod2_MA1993.2 6 bp overlap
Motif DE_48h DE_48h-Neurod2_MA1993.2 6 bp overlap
Motif DE_60h DE_60h-Neurod2_MA1993.2 6 bp overlap
Motif DE_60h DE_60h-Neurod2_MA1993.2 6 bp overlap
Motif DE_72h DE_72h-Neurod2_MA1993.2 6 bp overlap
Motif DE_72h DE_72h-Neurod2_MA1993.2 6 bp overlap
Nfat5 1 dataset
Motif DE_72h DE_72h-Nfat5_MA0606.3 8 bp overlap
Nfatc1 1 dataset
Motif DE_72h DE_72h-Nfatc1_MA0624.3 6 bp overlap
OTX1 3 datasets
Motif DE_48h DE_48h-OTX1_MA0711.2 6 bp overlap
Motif DE_60h DE_60h-OTX1_MA0711.2 6 bp overlap
Motif DE_72h DE_72h-OTX1_MA0711.2 6 bp overlap
Olig2 6 datasets
Motif DE_48h DE_48h-Olig2_MA1997.2 6 bp overlap
Motif DE_48h DE_48h-Olig2_MA1997.2 6 bp overlap
Motif DE_60h DE_60h-Olig2_MA1997.2 6 bp overlap
Motif DE_60h DE_60h-Olig2_MA1997.2 6 bp overlap
Motif DE_72h DE_72h-Olig2_MA1997.2 6 bp overlap
Motif DE_72h DE_72h-Olig2_MA1997.2 6 bp overlap
PAX2 3 datasets
Motif DE_48h DE_48h-PAX2_MA0067.3 16 bp overlap
Motif DE_60h DE_60h-PAX2_MA0067.3 16 bp overlap
Motif DE_72h DE_72h-PAX2_MA0067.3 16 bp overlap
PITX1 3 datasets
Motif DE_48h DE_48h-PITX1_MA0682.3 6 bp overlap
Motif DE_60h DE_60h-PITX1_MA0682.3 6 bp overlap
Motif DE_72h DE_72h-PITX1_MA0682.3 6 bp overlap
PITX3 3 datasets
Motif DE_48h DE_48h-PITX3_MA0714.2 6 bp overlap
Motif DE_60h DE_60h-PITX3_MA0714.2 6 bp overlap
Motif DE_72h DE_72h-PITX3_MA0714.2 6 bp overlap
POU4F2 1 dataset
ChIP HNPC_DIF GSE74814.POU4F2.HNPC_DIF 236 bp overlap
RBBP5 1 dataset
ChIP WA01 ENCSR000AQC.RBBP5.WA01 260 bp overlap
RHOXF1 3 datasets
Motif DE_48h DE_48h-RHOXF1_MA0719.2 6 bp overlap
Motif DE_60h DE_60h-RHOXF1_MA0719.2 6 bp overlap
Motif DE_72h DE_72h-RHOXF1_MA0719.2 6 bp overlap
SMAD2 1 dataset
ChIP endoderm GSE29422.SMAD2.endoderm 203 bp overlap
SMAD2-3 1 dataset
ChIP HUES-8_DE GSE109524.SMAD2-3.HUES-8_DE 520 bp overlap
SMAD2_3 2 datasets
ChIP DE_D2 S01-DE-d2-SMAD2_3-exp1 454 bp overlap
ChIP DE_D2 S53-DE-d2-SMAD2_3-exp2 475 bp overlap
SMAD3 1 dataset
ChIP endoderm GSE29422.SMAD3.endoderm 174 bp overlap
SMARCA4 2 datasets
ChIP NPC_siCT GSE122631.SMARCA4.NPC_siCT 463 bp overlap
ChIP hiPSC_WT GSE124903.SMARCA4.hiPSC_WT 331 bp overlap
SMARCB1 1 dataset
ChIP hiPSC_WT GSE124903.SMARCB1.hiPSC_WT 175 bp overlap
SMARCC1 1 dataset
ChIP hiPSC_WT GSE124903.SMARCC1.hiPSC_WT 336 bp overlap
SOX13 3 datasets
Motif DE_48h DE_48h-SOX13_MA1120.2 7 bp overlap
Motif DE_60h DE_60h-SOX13_MA1120.2 7 bp overlap
Motif DE_72h DE_72h-SOX13_MA1120.2 7 bp overlap
SOX17 1 dataset
ChIP DE_D2 DED2-SOX17_Batch_II 299 bp overlap
SOX17_M 1 dataset
ChIP DE_D2 DED2-SOX17-M_Batch_II 311 bp overlap
SOX18 3 datasets
Motif DE_48h DE_48h-SOX18_MA1563.2 8 bp overlap
Motif DE_60h DE_60h-SOX18_MA1563.2 8 bp overlap
Motif DE_72h DE_72h-SOX18_MA1563.2 8 bp overlap
SOX2 6 datasets
Motif DE_48h DE_48h-SOX2_MA0143.5 7 bp overlap
Motif DE_60h DE_60h-SOX2_MA0143.5 7 bp overlap
Motif DE_72h DE_72h-SOX2_MA0143.5 7 bp overlap
ChIP HNSC GSE69479.SOX2.HNSC 366 bp overlap
ChIP hiPSC GSE56567.SOX2.hiPSC 235 bp overlap
ChIP hiPSC GSE67282.SOX2.hiPSC 212 bp overlap
SOX21 3 datasets
Motif DE_48h DE_48h-SOX21_MA0866.1 15 bp overlap
Motif DE_60h DE_60h-SOX21_MA0866.1 15 bp overlap
Motif DE_72h DE_72h-SOX21_MA0866.1 15 bp overlap
SOX4 6 datasets
Motif DE_48h DE_48h-SOX4_MA0867.3 8 bp overlap
Motif DE_48h DE_48h-SOX4_MA0867.3 8 bp overlap
Motif DE_60h DE_60h-SOX4_MA0867.3 8 bp overlap
Motif DE_60h DE_60h-SOX4_MA0867.3 8 bp overlap
Motif DE_72h DE_72h-SOX4_MA0867.3 8 bp overlap
Motif DE_72h DE_72h-SOX4_MA0867.3 8 bp overlap
SOX8 6 datasets
Motif DE_48h DE_48h-SOX8_MA0868.3 7 bp overlap
Motif DE_48h DE_48h-SOX8_MA0868.3 7 bp overlap
Motif DE_60h DE_60h-SOX8_MA0868.3 7 bp overlap
Motif DE_60h DE_60h-SOX8_MA0868.3 7 bp overlap
Motif DE_72h DE_72h-SOX8_MA0868.3 7 bp overlap
Motif DE_72h DE_72h-SOX8_MA0868.3 7 bp overlap
SOX9 6 datasets
Motif DE_48h DE_48h-SOX9_MA0077.2 8 bp overlap
Motif DE_48h DE_48h-SOX9_MA0077.2 8 bp overlap
Motif DE_60h DE_60h-SOX9_MA0077.2 8 bp overlap
Motif DE_60h DE_60h-SOX9_MA0077.2 8 bp overlap
Motif DE_72h DE_72h-SOX9_MA0077.2 8 bp overlap
Motif DE_72h DE_72h-SOX9_MA0077.2 8 bp overlap
SP1 2 datasets
ChIP H1 ENCFF263FUH 321 bp overlap
ChIP WA01 ENCSR000BIR.SP1.WA01 303 bp overlap
STAT1::STAT2 2 datasets
Motif DE_48h DE_48h-STAT1STAT2_MA0517.2 13 bp overlap
Motif DE_72h DE_72h-STAT1STAT2_MA0517.2 13 bp overlap
Sox1 3 datasets
Motif DE_48h DE_48h-Sox1_MA0870.1 15 bp overlap
Motif DE_60h DE_60h-Sox1_MA0870.1 15 bp overlap
Motif DE_72h DE_72h-Sox1_MA0870.1 15 bp overlap
Sox17 3 datasets
Motif DE_48h DE_48h-Sox17_MA0078.3 10 bp overlap
Motif DE_60h DE_60h-Sox17_MA0078.3 10 bp overlap
Motif DE_72h DE_72h-Sox17_MA0078.3 10 bp overlap
Sox3 3 datasets
Motif DE_48h DE_48h-Sox3_MA0514.3 7 bp overlap
Motif DE_60h DE_60h-Sox3_MA0514.3 7 bp overlap
Motif DE_72h DE_72h-Sox3_MA0514.3 7 bp overlap
Sox5 6 datasets
Motif DE_48h DE_48h-Sox5_MA0087.3 8 bp overlap
Motif DE_48h DE_48h-Sox5_MA0087.3 8 bp overlap
Motif DE_60h DE_60h-Sox5_MA0087.3 8 bp overlap
Motif DE_60h DE_60h-Sox5_MA0087.3 8 bp overlap
Motif DE_72h DE_72h-Sox5_MA0087.3 8 bp overlap
Motif DE_72h DE_72h-Sox5_MA0087.3 8 bp overlap
Sox7 3 datasets
Motif DE_48h DE_48h-Sox7_MA2095.1 10 bp overlap
Motif DE_60h DE_60h-Sox7_MA2095.1 10 bp overlap
Motif DE_72h DE_72h-Sox7_MA2095.1 10 bp overlap
Stat2 3 datasets
Motif DE_48h DE_48h-Stat2_MA1623.2 10 bp overlap
Motif DE_60h DE_60h-Stat2_MA1623.2 10 bp overlap
Motif DE_72h DE_72h-Stat2_MA1623.2 10 bp overlap
TAF1 1 dataset
ChIP WA01 ENCSR000BHO.TAF1.WA01 147 bp overlap
TCF12 1 dataset
ChIP WA01 ENCSR000BIT.TCF12.WA01 275 bp overlap
TCF3 1 dataset
ChIP NPC GSE154479.TCF3.NPC 491 bp overlap
TFAP4::FLI1 3 datasets
Motif DE_48h DE_48h-TFAP4FLI1_MA1967.2 14 bp overlap
Motif DE_60h DE_60h-TFAP4FLI1_MA1967.2 14 bp overlap
Motif DE_72h DE_72h-TFAP4FLI1_MA1967.2 14 bp overlap
THRB 2 datasets
Motif DE_48h DE_48h-THRB_MA1574.2 13 bp overlap
Motif DE_72h DE_72h-THRB_MA1574.2 13 bp overlap
Tcf12 6 datasets
Motif DE_48h DE_48h-Tcf12_MA0521.3 6 bp overlap
Motif DE_48h DE_48h-Tcf12_MA0521.3 6 bp overlap
Motif DE_60h DE_60h-Tcf12_MA0521.3 6 bp overlap
Motif DE_60h DE_60h-Tcf12_MA0521.3 6 bp overlap
Motif DE_72h DE_72h-Tcf12_MA0521.3 6 bp overlap
Motif DE_72h DE_72h-Tcf12_MA0521.3 6 bp overlap
Thap11 3 datasets
Motif DE_48h DE_48h-Thap11_MA1573.2 14 bp overlap
Motif DE_60h DE_60h-Thap11_MA1573.2 14 bp overlap
Motif DE_72h DE_72h-Thap11_MA1573.2 14 bp overlap
Twist2 6 datasets
Motif DE_48h DE_48h-Twist2_MA0633.3 6 bp overlap
Motif DE_48h DE_48h-Twist2_MA0633.3 6 bp overlap
Motif DE_60h DE_60h-Twist2_MA0633.3 6 bp overlap
Motif DE_60h DE_60h-Twist2_MA0633.3 6 bp overlap
Motif DE_72h DE_72h-Twist2_MA0633.3 6 bp overlap
Motif DE_72h DE_72h-Twist2_MA0633.3 6 bp overlap
VDR 1 dataset
ChIP THP-1_2h_1-25-OH-2D3 GSE89431.VDR.THP-1_2h_1-25-OH-2D3 168 bp overlap
YY1 1 dataset
ChIP WA01 ENCSR000BKD.YY1.WA01 368 bp overlap
ZBTB18 6 datasets
Motif DE_48h DE_48h-ZBTB18_MA0698.2 11 bp overlap
Motif DE_48h DE_48h-ZBTB18_MA0698.2 11 bp overlap
Motif DE_60h DE_60h-ZBTB18_MA0698.2 11 bp overlap
Motif DE_60h DE_60h-ZBTB18_MA0698.2 11 bp overlap
Motif DE_72h DE_72h-ZBTB18_MA0698.2 11 bp overlap
Motif DE_72h DE_72h-ZBTB18_MA0698.2 11 bp overlap
ZFP42 3 datasets
Motif DE_48h DE_48h-ZFP42_MA1651.2 13 bp overlap
Motif DE_60h DE_60h-ZFP42_MA1651.2 13 bp overlap
Motif DE_72h DE_72h-ZFP42_MA1651.2 13 bp overlap
ZFP69B 1 dataset
ChIP HEK293T GSE78099.ZFP69B.HEK293T 121 bp overlap
ZFP91 2 datasets
ChIP K-562 ENCSR898XMH.ZFP91.K-562 369 bp overlap
ChIP K562 ENCFF501CDP 400 bp overlap
ZNF148 2 datasets
Motif DE_48h DE_48h-ZNF148_MA1653.2 10 bp overlap
Motif DE_72h DE_72h-ZNF148_MA1653.2 10 bp overlap
ZNF16 3 datasets
Motif DE_48h DE_48h-ZNF16_MA1654.2 21 bp overlap
Motif DE_60h DE_60h-ZNF16_MA1654.2 21 bp overlap
Motif DE_72h DE_72h-ZNF16_MA1654.2 21 bp overlap
ZNF257 3 datasets
Motif DE_48h DE_48h-ZNF257_MA1710.2 10 bp overlap
Motif DE_60h DE_60h-ZNF257_MA1710.2 10 bp overlap
Motif DE_72h DE_72h-ZNF257_MA1710.2 10 bp overlap
ZNF281 5 datasets
Motif DE_48h DE_48h-ZNF281_MA1630.3 10 bp overlap
Motif DE_48h DE_48h-ZNF281_MA1630.3 10 bp overlap
Motif DE_60h DE_60h-ZNF281_MA1630.3 10 bp overlap
Motif DE_72h DE_72h-ZNF281_MA1630.3 10 bp overlap
Motif DE_72h DE_72h-ZNF281_MA1630.3 10 bp overlap
ZNF354A 3 datasets
Motif DE_48h DE_48h-ZNF354A_MA1978.2 20 bp overlap
Motif DE_60h DE_60h-ZNF354A_MA1978.2 20 bp overlap
Motif DE_72h DE_72h-ZNF354A_MA1978.2 20 bp overlap
ZNF384 3 datasets
Motif DE_48h DE_48h-ZNF384_MA1125.2 8 bp overlap
Motif DE_60h DE_60h-ZNF384_MA1125.2 8 bp overlap
Motif DE_72h DE_72h-ZNF384_MA1125.2 8 bp overlap
ZNF75A 1 dataset
Motif DE_72h DE_72h-ZNF75A_MA2097.1 12 bp overlap
ZNF75D 1 dataset
Motif DE_72h DE_72h-ZNF75D_MA1601.2 12 bp overlap