Genomic view centred on this element. Tracks include ATAC-seq accessibility, RNA-seq expression, TF binding peaks, and element-to-gene loop arcs across the ESC → DE time course.

Transcription factors with ChIP-seq peak overlap or TOBIAS motif footprint evidence at this element.

TF Binding

43 transcription factors

CTCF 5 datasets

Motif DE_48h DE_48h-CTCF_MA1929.2 31 bp overlap

Motif DE_60h DE_60h-CTCF_MA1929.2 31 bp overlap

Motif DE_72h DE_72h-CTCF_MA1929.2 31 bp overlap

ChIP HEK293 ENCSR617IFZ.CTCF.HEK293 270 bp overlap

ChIP endodermal cell ENCFF471YCZ 276 bp overlap

Crx 2 datasets

Motif DE_48h DE_48h-Crx_MA0467.3 6 bp overlap

Motif DE_60h DE_60h-Crx_MA0467.3 6 bp overlap

DMRT3 2 datasets

Motif DE_48h DE_48h-DMRT3_MA0610.2 7 bp overlap

Motif DE_60h DE_60h-DMRT3_MA0610.2 7 bp overlap

DMRTC2 1 dataset

Motif DE_48h DE_48h-DMRTC2_MA1479.2 11 bp overlap

EOMES 1 dataset

ChIP hESC GSE26097.EOMES.hESC 382 bp overlap

ETS1 1 dataset

ChIP cardiomyocyte_D9 GSE129986.ETS1.cardiomyocyte_D9 473 bp overlap

EZH2 2 datasets

ChIP HCT-116 ENCSR046HGP.EZH2.HCT-116 272 bp overlap

ChIP LNCaP GSE39459.EZH2.LNCaP 203 bp overlap

FOXA2 2 datasets

ChIP DE DE-FOXA2-1 604 bp overlap

ChIP DE DE-FOXA2-2 545 bp overlap

GATA3_Nter 1 dataset

ChIP T-47D_CR3flp GSE99479.GATA3_Nter.T-47D_CR3flp 159 bp overlap

GATA4 2 datasets

ChIP DE DE-GATA4-1 605 bp overlap

ChIP DE DE-GATA4-2 605 bp overlap

GATA6 9 datasets

ChIP DE DE-GATA6-1 605 bp overlap

ChIP DE DE-GATA6-2 589 bp overlap

ChIP DE_D1 S09-DE-d1-GATA6-exp1 401 bp overlap

ChIP DE_D1 S14-DE-d1-GATA6-exp1 468 bp overlap

ChIP DE_D1 S41-DE-d1-GATA6-exp2 358 bp overlap

ChIP DE_D2 S55-DE-d2-GATA6-exp2 431 bp overlap

ChIP HUES-8_DE_JNKi GSE109524.GATA6.HUES-8_DE_JNKi 490 bp overlap

ChIP HUES-8_DE_ctrl GSE109524.GATA6.HUES-8_DE_ctrl 409 bp overlap

ChIP endoderm_KO GSE117136.GATA6.endoderm_KO 524 bp overlap

GSC 2 datasets

Motif DE_48h DE_48h-GSC_MA0648.2 6 bp overlap

Motif DE_60h DE_60h-GSC_MA0648.2 6 bp overlap

GSC2 2 datasets

Motif DE_48h DE_48h-GSC2_MA0891.2 6 bp overlap

Motif DE_60h DE_60h-GSC2_MA0891.2 6 bp overlap

Hoxd13 2 datasets

Motif DE_48h DE_48h-Hoxd13_MA0909.4 7 bp overlap

Motif DE_60h DE_60h-Hoxd13_MA0909.4 7 bp overlap

MGA::EVX1 2 datasets

Motif DE_48h DE_48h-MGAEVX1_MA1960.2 11 bp overlap

Motif DE_60h DE_60h-MGAEVX1_MA1960.2 11 bp overlap

NCOA2 1 dataset

ChIP MCF-7 ERP000901.NCOA2.MCF-7 164 bp overlap

NKX2-2 2 datasets

Motif DE_48h DE_48h-NKX2-2_MA1645.2 8 bp overlap

Motif DE_60h DE_60h-NKX2-2_MA1645.2 8 bp overlap

NKX2-5 2 datasets

ChIP hESC_ab3584 GSE89457.NKX2-5.hESC_ab3584 439 bp overlap

ChIP hESC_sc-14033 GSE89457.NKX2-5.hESC_sc-14033 382 bp overlap

NOTCH3 1 dataset

ChIP TALL-1_GSI GSE104261.NOTCH3.TALL-1_GSI 186 bp overlap

NR2C2 2 datasets

Motif DE_48h DE_48h-NR2C2_MA0504.2 14 bp overlap

Motif DE_60h DE_60h-NR2C2_MA0504.2 14 bp overlap

OTX1 2 datasets

Motif DE_48h DE_48h-OTX1_MA0711.2 6 bp overlap

Motif DE_60h DE_60h-OTX1_MA0711.2 6 bp overlap

PHF19 1 dataset

ChIP DU145_CTR GSE135623.PHF19.DU145_CTR 275 bp overlap

PITX1 2 datasets

Motif DE_48h DE_48h-PITX1_MA0682.3 6 bp overlap

Motif DE_60h DE_60h-PITX1_MA0682.3 6 bp overlap

PITX3 2 datasets

Motif DE_48h DE_48h-PITX3_MA0714.2 6 bp overlap

Motif DE_60h DE_60h-PITX3_MA0714.2 6 bp overlap

POU4F2 1 dataset

ChIP HNPC_DIF GSE74814.POU4F2.HNPC_DIF 127 bp overlap

PPARA::RXRA 2 datasets

Motif DE_48h DE_48h-PPARARXRA_MA1148.2 17 bp overlap

Motif DE_60h DE_60h-PPARARXRA_MA1148.2 17 bp overlap

Pparg::Rxra 2 datasets

Motif DE_48h DE_48h-PpargRxra_MA0065.3 13 bp overlap

Motif DE_60h DE_60h-PpargRxra_MA0065.3 13 bp overlap

RAD21 1 dataset

ChIP H1 ENCFF698EWO 241 bp overlap

RHOXF1 2 datasets

Motif DE_48h DE_48h-RHOXF1_MA0719.2 6 bp overlap

Motif DE_60h DE_60h-RHOXF1_MA0719.2 6 bp overlap

SIX2 2 datasets

ChIP HEK GSE73865.SIX2.HEK 220 bp overlap

ChIP kidney_fetal_17w GSE75948.SIX2.kidney_fetal_17w 161 bp overlap

SMAD2 1 dataset

ChIP endoderm GSE29422.SMAD2.endoderm 476 bp overlap

SMAD2-3 3 datasets

ChIP HUES-8_DE GSE109524.SMAD2-3.HUES-8_DE 545 bp overlap

ChIP HUES-8_DE_JNKi GSE109524.SMAD2-3.HUES-8_DE_JNKi 509 bp overlap

ChIP HUES-8_DE_ctrl GSE109524.SMAD2-3.HUES-8_DE_ctrl 522 bp overlap

SMAD2_3 5 datasets

ChIP DE_D1 S07-DE-d1-SMAD2_3-exp1 477 bp overlap

ChIP DE_D1 S12-DE-d1-SMAD2_3-exp1 440 bp overlap

ChIP DE_D1 S39-DE-d1-SMAD2_3-exp2 513 bp overlap

ChIP DE_D2 S01-DE-d2-SMAD2_3-exp1 505 bp overlap

ChIP DE_D2 S53-DE-d2-SMAD2_3-exp2 457 bp overlap

SMAD3 1 dataset

ChIP endoderm GSE29422.SMAD3.endoderm 313 bp overlap

SMAD4 1 dataset

ChIP endoderm GSE29422.SMAD4.endoderm 333 bp overlap

SOX17 1 dataset

ChIP DE_D2 DED2-SOX17_Batch_II 373 bp overlap

SOX17_M 1 dataset

ChIP DE_D2 DED2-SOX17-M_Batch_II 494 bp overlap

T 1 dataset

ChIP H9_ENDODERM GSE60606.T.H9_ENDODERM 194 bp overlap

ZFP14 2 datasets

Motif DE_48h DE_48h-ZFP14_MA1972.1 15 bp overlap

Motif DE_60h DE_60h-ZFP14_MA1972.1 15 bp overlap

ZNF766 2 datasets

Motif DE_48h DE_48h-ZNF766_MA2098.1 9 bp overlap

Motif DE_60h DE_60h-ZNF766_MA2098.1 9 bp overlap

ZNF768 3 datasets

Motif DE_48h DE_48h-ZNF768_MA1731.2 9 bp overlap

Motif DE_60h DE_60h-ZNF768_MA1731.2 9 bp overlap

Motif DE_72h DE_72h-ZNF768_MA1731.2 9 bp overlap

ZSCAN16 2 datasets

Motif DE_48h DE_48h-ZSCAN16_MA2100.1 18 bp overlap

Motif DE_60h DE_60h-ZSCAN16_MA2100.1 18 bp overlap

Zic2 3 datasets

Motif DE_48h DE_48h-Zic2_MA1629.2 9 bp overlap

Motif DE_60h DE_60h-Zic2_MA1629.2 9 bp overlap

Motif DE_72h DE_72h-Zic2_MA1629.2 9 bp overlap

Gene	Dist. to TSS	Distance	Link type
ENSG00000286257	10.7 kb	Distal	Multiome
LINC03059	62.6 kb	Distal	Multiome
EXOC5	218.8 kb	Distal	Multiome
AP5M1	218.9 kb	Distal	Multiome
OTX2-AS1	236.9 kb	Distal	Multiome+HiCAR
OTX2	244.4 kb	Distal	Multiome+HiCAR

Genome Browser