chr16 : 51,449,102 – 51,449,934

832 bp 110 TFs 3 linked genes

This 832 bp open chromatin element is linked to HNRNPA1L3, SALL1, and ENSG00000285367 and is bound by 110 transcription factors.

Linked Genes

3 genes

Gene	Dist. to TSS	Distance	Link type
HNRNPA1L3	196.2 kb	Distal	Multiome
SALL1	297.2 kb	Distal	Multiome
ENSG00000285367	297.4 kb	Distal	Multiome

Chromatin Accessibility

Genome Browser

Genomic view centred on this element. Tracks include ATAC-seq accessibility, RNA-seq expression, TF binding peaks, and element-to-gene loop arcs across the ESC → DE time course.

Transcription factors with ChIP-seq peak overlap or TOBIAS motif footprint evidence at this element.

TF Binding

110 transcription factors

ARNT 1 dataset

ChIP RCC4 GSE85352.ARNT.RCC4 204 bp overlap

BARX1 2 datasets

Motif DE_36h DE_36h-BARX1_MA0875.2 6 bp overlap

Motif DE_48h DE_48h-BARX1_MA0875.2 6 bp overlap

BRD4 7 datasets

ChIP HEK293_Ctrl GSE129407.BRD4.HEK293_Ctrl 314 bp overlap

ChIP Kelly_sensitive GSE103030.BRD4.Kelly_sensitive 200 bp overlap

ChIP cortical-interneuron_R133C_KCl-neg_JQ1-neg GSE117508.BRD4.cortical-interneuron_R133C_KCl-neg_JQ1-neg 300 bp overlap

ChIP cortical-interneuron_R133C_KCl-pos_JQ1-neg GSE117508.BRD4.cortical-interneuron_R133C_KCl-pos_JQ1-neg 183 bp overlap

ChIP retina_AB1-FW15 GSE86981.BRD4.retina_AB1-FW15 560 bp overlap

ChIP retina_AB1-FW20 GSE86981.BRD4.retina_AB1-FW20 316 bp overlap

ChIP retina_AB1-RB GSE86981.BRD4.retina_AB1-RB 305 bp overlap

BSX 2 datasets

Motif DE_36h DE_36h-BSX_MA0876.2 6 bp overlap

Motif DE_48h DE_48h-BSX_MA0876.2 6 bp overlap

CHD7 1 dataset

ChIP hiPSC_derived_lt-NES GSE108506.CHD7.hiPSC_derived_lt-NES 300 bp overlap

Cebpa 1 dataset

ChIP BLaER1 ENCFF364PUR 118 bp overlap

DLX1 2 datasets

Motif DE_36h DE_36h-DLX1_MA0879.3 6 bp overlap

Motif DE_48h DE_48h-DLX1_MA0879.3 6 bp overlap

DLX6 2 datasets

Motif DE_36h DE_36h-DLX6_MA0882.2 6 bp overlap

Motif DE_48h DE_48h-DLX6_MA0882.2 6 bp overlap

Dlx2 2 datasets

Motif DE_36h DE_36h-Dlx2_MA0885.3 8 bp overlap

Motif DE_48h DE_48h-Dlx2_MA0885.3 8 bp overlap

Dlx3 2 datasets

Motif DE_36h DE_36h-Dlx3_MA0880.2 6 bp overlap

Motif DE_48h DE_48h-Dlx3_MA0880.2 6 bp overlap

Dlx4 2 datasets

Motif DE_36h DE_36h-Dlx4_MA0881.2 6 bp overlap

Motif DE_48h DE_48h-Dlx4_MA0881.2 6 bp overlap

Dlx5 2 datasets

Motif DE_36h DE_36h-Dlx5_MA1476.3 8 bp overlap

Motif DE_48h DE_48h-Dlx5_MA1476.3 8 bp overlap

E2F6 1 dataset

Motif DE_48h DE_48h-E2F6_MA0471.3 8 bp overlap

EN2 2 datasets

Motif DE_36h DE_36h-EN2_MA0642.3 7 bp overlap

Motif DE_48h DE_48h-EN2_MA0642.3 7 bp overlap

EOMES 2 datasets

ChIP hESC GSE26097.EOMES.hESC 180 bp overlap

ChIP hESC GSE26097.EOMES.hESC 173 bp overlap

EZH2 2 datasets

ChIP A-1847_CARM1-KO GSE95643.EZH2.A-1847_CARM1-KO 430 bp overlap

ChIP neural progenitor cell ENCFF018MKA 809 bp overlap

Elf5 1 dataset

Motif DE_48h DE_48h-Elf5_MA0136.4 8 bp overlap

FLI1 1 dataset

ChIP A-673_D17 GSE129155.FLI1.A-673_D17 206 bp overlap

FOXA2 2 datasets

ChIP DE DE-FOXA2-1 333 bp overlap

ChIP DE DE-FOXA2-2 295 bp overlap

FOXC2 1 dataset

Motif DE_48h DE_48h-FOXC2_MA0846.2 11 bp overlap

FOXD2 1 dataset

Motif DE_48h DE_48h-FOXD2_MA0847.4 11 bp overlap

FOXE1 1 dataset

Motif DE_48h DE_48h-FOXE1_MA1487.3 12 bp overlap

FOXF2 1 dataset

Motif DE_48h DE_48h-FOXF2_MA0030.2 9 bp overlap

FOXG1 1 dataset

Motif DE_48h DE_48h-FOXG1_MA0613.1 8 bp overlap

FOXH1 1 dataset

Motif DE_48h DE_48h-FOXH1_MA0479.2 8 bp overlap

FOXK1 1 dataset

Motif DE_48h DE_48h-FOXK1_MA0852.3 7 bp overlap

FOXK2 1 dataset

Motif DE_48h DE_48h-FOXK2_MA1103.3 7 bp overlap

FOXL1 1 dataset

Motif DE_48h DE_48h-FOXL1_MA0033.2 7 bp overlap

FOXO4 1 dataset

Motif DE_48h DE_48h-FOXO4_MA0848.1 7 bp overlap

FOXO6 1 dataset

Motif DE_48h DE_48h-FOXO6_MA0849.1 7 bp overlap

FOXP2 1 dataset

Motif DE_48h DE_48h-FOXP2_MA0593.2 9 bp overlap

FOXP3 1 dataset

Motif DE_48h DE_48h-FOXP3_MA0850.1 7 bp overlap

Foxf1 1 dataset

Motif DE_48h DE_48h-Foxf1_MA1606.2 7 bp overlap

Foxj3 1 dataset

Motif DE_48h DE_48h-Foxj3_MA0851.2 9 bp overlap

Foxo1 1 dataset

Motif DE_48h DE_48h-Foxo1_MA0480.3 7 bp overlap

Foxo3 1 dataset

Motif DE_48h DE_48h-Foxo3_MA0157.4 7 bp overlap

Foxq1 1 dataset

Motif DE_48h DE_48h-Foxq1_MA0040.2 10 bp overlap

GATA1::TAL1 1 dataset

Motif DE_36h DE_36h-GATA1TAL1_MA0140.3 17 bp overlap

GATA3 1 dataset

ChIP Kelly GSE65664.GATA3.Kelly 251 bp overlap

GATA4 4 datasets

ChIP DE DE-GATA4-1 573 bp overlap

ChIP DE DE-GATA4-2 832 bp overlap

Motif DE_48h DE_48h-GATA4_MA0482.3 8 bp overlap

ChIP pancreatic-progenitor_PP1 GSE104840.GATA4.pancreatic-progenitor_PP1 256 bp overlap

GATA6 10 datasets

ChIP DE DE-GATA6-1 562 bp overlap

ChIP DE DE-GATA6-2 521 bp overlap

ChIP DE_D1 S09-DE-d1-GATA6-exp1 584 bp overlap

ChIP DE_D1 S14-DE-d1-GATA6-exp1 780 bp overlap

ChIP DE_D1 S41-DE-d1-GATA6-exp2 566 bp overlap

ChIP DE_D2 S55-DE-d2-GATA6-exp2 442 bp overlap

ChIP HUES-8_DE_JNKi GSE109524.GATA6.HUES-8_DE_JNKi 832 bp overlap

ChIP HUES-8_DE_ctrl GSE109524.GATA6.HUES-8_DE_ctrl 594 bp overlap

ChIP foregut GSE117136.GATA6.foregut 261 bp overlap

ChIP foregut_KO GSE117136.GATA6.foregut_KO 368 bp overlap

GBX1 2 datasets

Motif DE_36h DE_36h-GBX1_MA0889.2 7 bp overlap

Motif DE_48h DE_48h-GBX1_MA0889.2 7 bp overlap

GBX2 2 datasets

Motif DE_36h DE_36h-GBX2_MA0890.2 6 bp overlap

Motif DE_48h DE_48h-GBX2_MA0890.2 6 bp overlap

HAND2 2 datasets

ChIP Kelly GSE94822.HAND2.Kelly 156 bp overlap

ChIP Kelly GSE94822.HAND2.Kelly 204 bp overlap

HCFC1R1 1 dataset

ChIP cartilage GSE100311.HCFC1R1.cartilage 196 bp overlap

HESX1 2 datasets

Motif DE_36h DE_36h-HESX1_MA0894.2 6 bp overlap

Motif DE_48h DE_48h-HESX1_MA0894.2 6 bp overlap

HMBOX1 1 dataset

Motif DE_36h DE_36h-HMBOX1_MA0895.2 7 bp overlap

HOXA7 2 datasets

Motif DE_36h DE_36h-HOXA7_MA1498.3 6 bp overlap

Motif DE_48h DE_48h-HOXA7_MA1498.3 6 bp overlap

HSF2 1 dataset

Motif DE_36h DE_36h-HSF2_MA0770.1 13 bp overlap

IKZF2 1 dataset

Motif DE_48h DE_48h-IKZF2_MA2326.1 6 bp overlap

Isl1 1 dataset

Motif DE_36h DE_36h-Isl1_MA1608.2 7 bp overlap

JUN 1 dataset

ChIP DE_D1 S40-DE-d1-JUN-exp2 284 bp overlap

KLF16 1 dataset

Motif DE_48h DE_48h-KLF16_MA0741.1 11 bp overlap

KLF9 1 dataset

Motif DE_48h DE_48h-KLF9_MA1107.3 11 bp overlap

LBX1 2 datasets

Motif DE_36h DE_36h-LBX1_MA0618.2 7 bp overlap

Motif DE_48h DE_48h-LBX1_MA0618.2 7 bp overlap

LBX2 2 datasets

Motif DE_36h DE_36h-LBX2_MA0699.2 6 bp overlap

Motif DE_48h DE_48h-LBX2_MA0699.2 6 bp overlap

LHX2 2 datasets

Motif DE_36h DE_36h-LHX2_MA0700.3 6 bp overlap

Motif DE_48h DE_48h-LHX2_MA0700.3 6 bp overlap

LHX9 2 datasets

Motif DE_36h DE_36h-LHX9_MA0701.3 7 bp overlap

Motif DE_48h DE_48h-LHX9_MA0701.3 7 bp overlap

Lhx1 1 dataset

Motif DE_36h DE_36h-Lhx1_MA1518.3 10 bp overlap

MGA::EVX1 1 dataset

Motif DE_48h DE_48h-MGAEVX1_MA1960.2 11 bp overlap

MSX1 2 datasets

Motif DE_36h DE_36h-MSX1_MA0666.3 6 bp overlap

Motif DE_48h DE_48h-MSX1_MA0666.3 6 bp overlap

MSX2 2 datasets

Motif DE_36h DE_36h-MSX2_MA0708.3 6 bp overlap

Motif DE_48h DE_48h-MSX2_MA0708.3 6 bp overlap

MYOG 1 dataset

ChIP RH30_DMSO GSE85169.MYOG.RH30_DMSO 148 bp overlap

Msx3 2 datasets

Motif DE_36h DE_36h-Msx3_MA0709.2 6 bp overlap

Motif DE_48h DE_48h-Msx3_MA0709.2 6 bp overlap

NFYB 1 dataset

Motif DE_36h DE_36h-NFYB_MA0502.3 9 bp overlap

NKX6-3 2 datasets

Motif DE_36h DE_36h-NKX6-3_MA1530.2 8 bp overlap

Motif DE_48h DE_48h-NKX6-3_MA1530.2 8 bp overlap

Nobox 2 datasets

Motif DE_36h DE_36h-Nobox_MA0125.2 6 bp overlap

Motif DE_48h DE_48h-Nobox_MA0125.2 6 bp overlap

PAX6 1 dataset

Motif DE_48h DE_48h-PAX6_MA0069.1 14 bp overlap

PHOX2A 1 dataset

Motif DE_36h DE_36h-PHOX2A_MA0713.1 11 bp overlap

PHOX2B 1 dataset

Motif DE_36h DE_36h-PHOX2B_MA0681.3 12 bp overlap

POU1F1 1 dataset

Motif DE_36h DE_36h-POU1F1_MA0784.3 14 bp overlap

POU2F2 1 dataset

Motif DE_36h DE_36h-POU2F2_MA0507.3 13 bp overlap

POU3F3 1 dataset

Motif DE_36h DE_36h-POU3F3_MA0788.1 13 bp overlap

POU5F1 1 dataset

ChIP DE_D1 DED1-OCT4_Batch_II 250 bp overlap

POU5F1_M 1 dataset

ChIP DE_D1 DED1-OCT4-M_Batch_II 240 bp overlap

PRRX2 2 datasets

Motif DE_36h DE_36h-PRRX2_MA0075.4 7 bp overlap

Motif DE_48h DE_48h-PRRX2_MA0075.4 7 bp overlap

RARA 1 dataset

ChIP hiPSC_D2 GSE132532.RARA.hiPSC_D2 259 bp overlap

RAX 2 datasets

Motif DE_36h DE_36h-RAX_MA0718.2 6 bp overlap

Motif DE_48h DE_48h-RAX_MA0718.2 6 bp overlap

RBPJ 2 datasets

Motif DE_48h DE_48h-RBPJ_MA1116.2 6 bp overlap

REL 1 dataset

Motif DE_36h DE_36h-REL_MA0101.1 10 bp overlap

RELA 2 datasets

ChIP 786-O GSE86092.RELA.786-O 275 bp overlap

Motif DE_36h DE_36h-RELA_MA0107.1 10 bp overlap

RUNX1 1 dataset

ChIP epididymis_HEE GSE109061.RUNX1.epididymis_HEE 197 bp overlap

SALL2 1 dataset

ChIP HEK293 GSE145940.SALL2.HEK293 317 bp overlap

SIX2 2 datasets

ChIP HEK GSE73865.SIX2.HEK 211 bp overlap

ChIP kidney_fetal_17w GSE75948.SIX2.kidney_fetal_17w 291 bp overlap

SMAD2-3 4 datasets

ChIP HUES-8_DE GSE109524.SMAD2-3.HUES-8_DE 301 bp overlap

ChIP HUES-8_DE GSE109524.SMAD2-3.HUES-8_DE 157 bp overlap

ChIP HUES-8_DE_JNKi GSE109524.SMAD2-3.HUES-8_DE_JNKi 635 bp overlap

ChIP HUES-8_DE_ctrl GSE109524.SMAD2-3.HUES-8_DE_ctrl 549 bp overlap

SMAD2_3 5 datasets

ChIP DE_D1 S07-DE-d1-SMAD2_3-exp1 384 bp overlap

ChIP DE_D1 S12-DE-d1-SMAD2_3-exp1 487 bp overlap

ChIP DE_D1 S39-DE-d1-SMAD2_3-exp2 427 bp overlap

ChIP DE_D2 S01-DE-d2-SMAD2_3-exp1 619 bp overlap

ChIP DE_D2 S53-DE-d2-SMAD2_3-exp2 375 bp overlap

SMARCA4 2 datasets

ChIP NPC_siSOX GSE122631.SMARCA4.NPC_siSOX 299 bp overlap

ChIP hiPSC GSE124903.SMARCA4.hiPSC 592 bp overlap

SMARCC1 4 datasets

ChIP TTC-549_Dox GSE71504.SMARCC1.TTC-549_Dox 153 bp overlap

ChIP TTC-549_NoDox GSE71504.SMARCC1.TTC-549_NoDox 235 bp overlap

ChIP TTC-549_NoDox GSE71504.SMARCC1.TTC-549_NoDox 227 bp overlap

ChIP hiPSC GSE124903.SMARCC1.hiPSC 187 bp overlap

SOX17 1 dataset

ChIP DE_D2 DED2-SOX17_Batch_II 334 bp overlap

SOX17_M 1 dataset

ChIP DE_D2 DED2-SOX17-M_Batch_II 403 bp overlap

SOX21 2 datasets

Motif DE_48h DE_48h-SOX21_MA0866.1 15 bp overlap

ChIP neuroepithelilal-cells GSE110505.SOX21.neuroepithelilal-cells 286 bp overlap

SP8 1 dataset

Motif DE_48h DE_48h-SP8_MA0747.2 11 bp overlap

SP9 1 dataset

Motif DE_48h DE_48h-SP9_MA1564.2 10 bp overlap

STAT1::STAT2 1 dataset

Motif DE_36h DE_36h-STAT1STAT2_MA0517.2 13 bp overlap

Sox1 1 dataset

Motif DE_48h DE_48h-Sox1_MA0870.1 15 bp overlap

TBX2 1 dataset

ChIP Kelly GSE94822.TBX2.Kelly 164 bp overlap

TEAD4 1 dataset

ChIP hMSC-TERT4 GSE140782.TEAD4.hMSC-TERT4 124 bp overlap

TP53 1 dataset

ChIP IMR-90 GSE42728.TP53.IMR-90 178 bp overlap

Tbx6 1 dataset

Motif DE_48h DE_48h-Tbx6_MA1567.3 9 bp overlap

VENTX 1 dataset

Motif DE_36h DE_36h-VENTX_MA0724.1 9 bp overlap

Wt1 2 datasets

Motif DE_36h DE_36h-Wt1_MA1627.2 10 bp overlap

Motif DE_48h DE_48h-Wt1_MA1627.2 10 bp overlap

ZKSCAN5 1 dataset

Motif DE_48h DE_48h-ZKSCAN5_MA1652.2 9 bp overlap

ZNF281 1 dataset

Motif DE_48h DE_48h-ZNF281_MA1630.3 10 bp overlap

ZNF354A 1 dataset

Motif DE_48h DE_48h-ZNF354A_MA1978.2 20 bp overlap

ZNF460 1 dataset

Motif DE_36h DE_36h-ZNF460_MA1596.1 16 bp overlap

ZNF530 1 dataset

Motif DE_48h DE_48h-ZNF530_MA1981.2 14 bp overlap

ZNF740 1 dataset

Motif DE_48h DE_48h-ZNF740_MA0753.3 10 bp overlap

ZNF75D 1 dataset

Motif DE_48h DE_48h-ZNF75D_MA1601.2 12 bp overlap

ZNF816 1 dataset

Motif DE_48h DE_48h-ZNF816_MA1719.2 15 bp overlap

Zfx 1 dataset

Motif DE_48h DE_48h-Zfx_MA0146.3 10 bp overlap