chr17 : 11,991,340 – 11,992,020

680 bp 61 TFs 3 linked genes

This 680 bp open chromatin element is linked to ZNF18, ENSG00000289910, and MAP2K4 and is bound by 61 transcription factors.

Linked Genes

3 genes

Gene	Dist. to TSS	Distance	Link type
ZNF18	5.4 kb	Proximal	Proximity
ENSG00000289910	5.6 kb	Proximal	Proximity
MAP2K4	29.1 kb	Distal	Multiome

Chromatin Accessibility

Genome Browser

Genomic view centred on this element. Tracks include ATAC-seq accessibility, RNA-seq expression, TF binding peaks, and element-to-gene loop arcs across the ESC → DE time course.

Transcription factors with ChIP-seq peak overlap or TOBIAS motif footprint evidence at this element.

TF Binding

61 transcription factors

ARNT::HIF1A 1 dataset

Motif DE_12h DE_12h-ARNTHIF1A_MA0259.2 5 bp overlap

ATF2 1 dataset

ChIP Hep-G2 ENCSR047BUZ.ATF2.Hep-G2 136 bp overlap

BCL11A 1 dataset

ChIP HUDEP-2_90min GSE104676.BCL11A.HUDEP-2_90min 86 bp overlap

BCOR 2 datasets

ChIP WA01_RNF2-R GSE104690.BCOR.WA01_RNF2-R 319 bp overlap

ChIP WA01_RNF2-R_Doxycyclin GSE104690.BCOR.WA01_RNF2-R_Doxycyclin 250 bp overlap

BHLHE22 1 dataset

Motif DE_24h DE_24h-BHLHE22_MA1635.2 6 bp overlap

Bhlha15 1 dataset

Motif DE_24h DE_24h-Bhlha15_MA1472.3 8 bp overlap

CREB1 1 dataset

ChIP GM23338 ENCSR214ZAV.CREB1.GM23338 164 bp overlap

EOMES 1 dataset

ChIP hESC GSE26097.EOMES.hESC 250 bp overlap

FIGLA 3 datasets

Motif DE_12h DE_12h-FIGLA_MA0820.2 6 bp overlap

Motif DE_24h DE_24h-FIGLA_MA0820.2 6 bp overlap

FOXA2 1 dataset

ChIP DE DE-FOXA2-1 438 bp overlap

GATA4 2 datasets

ChIP DE DE-GATA4-1 500 bp overlap

ChIP DE DE-GATA4-2 541 bp overlap

GATA6 7 datasets

ChIP DE DE-GATA6-1 669 bp overlap

ChIP DE DE-GATA6-2 558 bp overlap

ChIP DE_D1 S09-DE-d1-GATA6-exp1 362 bp overlap

ChIP DE_D1 S14-DE-d1-GATA6-exp1 427 bp overlap

ChIP DE_D1 S41-DE-d1-GATA6-exp2 564 bp overlap

ChIP HUES-8_DE_JNKi GSE109524.GATA6.HUES-8_DE_JNKi 492 bp overlap

ChIP HUES-8_DE_ctrl GSE109524.GATA6.HUES-8_DE_ctrl 529 bp overlap

HOXC13 1 dataset

Motif DE_24h DE_24h-HOXC13_MA0907.2 9 bp overlap

JUN 3 datasets

ChIP DE_D1 S08-DE-d1-JUN-exp1 299 bp overlap

ChIP ESC S34-ESC-d0-JUN-exp2 339 bp overlap

ChIP HUES-8_DE_ctrl GSE109524.JUN.HUES-8_DE_ctrl 499 bp overlap

MYF5 1 dataset

Motif DE_24h DE_24h-MYF5_MA1641.2 8 bp overlap

MYOD1 1 dataset

Motif DE_24h DE_24h-MYOD1_MA0499.3 9 bp overlap

NANOG 9 datasets

ChIP GM23338 ENCSR061DGF.NANOG.GM23338 198 bp overlap

ChIP HUES-8 GSE109524.NANOG.HUES-8 542 bp overlap

ChIP WA01 ERP004238.NANOG.WA01 476 bp overlap

ChIP WA01 ENCSR000BMT.NANOG.WA01 153 bp overlap

ChIP WA01_3IL ERP004238.NANOG.WA01_3IL 680 bp overlap

ChIP WA09 GSE105028.NANOG.WA09 503 bp overlap

ChIP WA09_heat-shock GSE105028.NANOG.WA09_heat-shock 369 bp overlap

ChIP hESC GSE20650.NANOG.hESC 176 bp overlap

ChIP hESC GSE18292.NANOG.hESC 189 bp overlap

NEUROD1 1 dataset

Motif DE_24h DE_24h-NEUROD1_MA1109.2 8 bp overlap

NHLH2 1 dataset

Motif DE_24h DE_24h-NHLH2_MA1529.2 16 bp overlap

NIPBL 2 datasets

ChIP hESC_WNT3A_ACTIVIN GSE64758.NIPBL.hESC_WNT3A_ACTIVIN 238 bp overlap

ChIP hESC_activin GSE64758.NIPBL.hESC_activin 281 bp overlap

Neurod2 2 datasets

Motif DE_24h DE_24h-Neurod2_MA0668.3 8 bp overlap

Motif DE_24h DE_24h-Neurod2_MA1993.2 6 bp overlap

OTX2 1 dataset

ChIP WTC11 ENCFF634NAO 245 bp overlap

Olig2 1 dataset

Motif DE_24h DE_24h-Olig2_MA1997.2 6 bp overlap

PBX3 1 dataset

Motif DE_24h DE_24h-PBX3_MA1114.2 11 bp overlap

PDX1 1 dataset

ChIP hiPSC GSE125768.PDX1.hiPSC 278 bp overlap

PKNOX1 1 dataset

Motif DE_24h DE_24h-PKNOX1_MA0782.3 10 bp overlap

POU2F1::SOX2 1 dataset

Motif DE_24h DE_24h-POU2F1SOX2_MA1962.1 17 bp overlap

POU5F1 5 datasets

ChIP DE_D1 DED1-OCT4_Batch_II 455 bp overlap

ChIP HUES-8 GSE109524.POU5F1.HUES-8 476 bp overlap

ChIP WA01 ENCSR000BMU.POU5F1.WA01 171 bp overlap

ChIP hESC_NAIVE GSE69646.POU5F1.hESC_NAIVE 557 bp overlap

ChIP hESC_PRIMED GSE69646.POU5F1.hESC_PRIMED 397 bp overlap

POU5F1_M 1 dataset

ChIP DE_D1 DED1-OCT4-M_Batch_II 478 bp overlap

PRDM9 1 dataset

Motif DE_24h DE_24h-PRDM9_MA1723.2 20 bp overlap

Pou5f1::Sox2 1 dataset

Motif DE_24h DE_24h-Pou5f1Sox2_MA0142.1 15 bp overlap

Ptf1A 1 dataset

Motif DE_24h DE_24h-Ptf1A_MA1619.2 8 bp overlap

RBPJ 1 dataset

Motif DE_24h DE_24h-RBPJ_MA1116.2 6 bp overlap

RFX1 1 dataset

ChIP K-562 ENCSR968GIB.RFX1.K-562 247 bp overlap

Runx1 1 dataset

Motif DE_24h DE_24h-Runx1_MA0002.3 9 bp overlap

SALL3 1 dataset

ChIP hiPSC GSE104863.SALL3.hiPSC 244 bp overlap

SMAD2 2 datasets

ChIP hESC GSE29422.SMAD2.hESC 189 bp overlap

ChIP hESC_activinA_15h GSE99202.SMAD2.hESC_activinA_15h 335 bp overlap

SMAD2-3 4 datasets

ChIP HUES-8 GSE109524.SMAD2-3.HUES-8 411 bp overlap

ChIP HUES-8_DE GSE109524.SMAD2-3.HUES-8_DE 407 bp overlap

ChIP HUES-8_DE_JNKi GSE109524.SMAD2-3.HUES-8_DE_JNKi 643 bp overlap

ChIP HUES-8_DE_ctrl GSE109524.SMAD2-3.HUES-8_DE_ctrl 651 bp overlap

SMAD2_3 5 datasets

ChIP DE_D1 S07-DE-d1-SMAD2_3-exp1 493 bp overlap

ChIP DE_D1 S12-DE-d1-SMAD2_3-exp1 586 bp overlap

ChIP DE_D1 S39-DE-d1-SMAD2_3-exp2 552 bp overlap

ChIP DE_D2 S01-DE-d2-SMAD2_3-exp1 420 bp overlap

ChIP ESC S33-ESC-d0-SMAD2_3-exp2 398 bp overlap

SMAD3 1 dataset

ChIP BG03 GSE21614.SMAD3.BG03 148 bp overlap

SNAI2 1 dataset

Motif DE_24h DE_24h-SNAI2_MA0745.3 8 bp overlap

SNAI3 1 dataset

Motif DE_24h DE_24h-SNAI3_MA1559.2 9 bp overlap

SOX10 1 dataset

Motif DE_24h DE_24h-SOX10_MA0442.3 6 bp overlap

SOX17 1 dataset

ChIP DE_D2 DED2-SOX17_Batch_II 280 bp overlap

SOX17_M 1 dataset

ChIP DE_D2 DED2-SOX17-M_Batch_II 309 bp overlap

SOX2 2 datasets

ChIP hESC GSE18292.SOX2.hESC 144 bp overlap

ChIP hiPSC GSE56567.SOX2.hiPSC 382 bp overlap

SOX4 1 dataset

Motif DE_24h DE_24h-SOX4_MA0867.3 8 bp overlap

SP1 1 dataset

ChIP WA01 ENCSR000BIR.SP1.WA01 172 bp overlap

STAT1::STAT2 1 dataset

Motif DE_24h DE_24h-STAT1STAT2_MA0517.2 13 bp overlap

TBX5 2 datasets

Motif DE_12h DE_12h-TBX5_MA0807.1 8 bp overlap

Motif DE_24h DE_24h-TBX5_MA0807.1 8 bp overlap

TCF12 1 dataset

ChIP WA01 ENCSR000BIT.TCF12.WA01 187 bp overlap

TFDP1 1 dataset

Motif DE_24h DE_24h-TFDP1_MA1122.2 8 bp overlap

Tcf12 1 dataset

Motif DE_24h DE_24h-Tcf12_MA0521.3 6 bp overlap

Twist2 1 dataset

Motif DE_24h DE_24h-Twist2_MA0633.3 6 bp overlap

ZBTB18 1 dataset

Motif DE_24h DE_24h-ZBTB18_MA0698.2 11 bp overlap

ZEB1 3 datasets

Motif DE_12h DE_12h-ZEB1_MA0103.4 6 bp overlap

Motif DE_24h DE_24h-ZEB1_MA0103.4 6 bp overlap

ZNF143 1 dataset

ChIP FLP143HA_T4 GSE39263.ZNF143.FLP143HA_T4 145 bp overlap

ZNF331 1 dataset

Motif DE_24h DE_24h-ZNF331_MA1726.2 10 bp overlap

ZNF35 1 dataset

Motif DE_12h DE_12h-ZNF35_MA2333.1 7 bp overlap

ZNF462 2 datasets

ChIP GM23338 ENCFF896CCA 251 bp overlap

ChIP GM23338 ENCSR334UWP.ZNF462.GM23338 629 bp overlap

Zic2 1 dataset

Motif DE_24h DE_24h-Zic2_MA1629.2 9 bp overlap