chr18 : 51,039,296 – 51,039,660

364 bp 79 TFs 2 linked genes

This 364 bp open chromatin element is linked to SMAD4 and ENSG00000289868 and is bound by 79 transcription factors.

Linked Genes

2 genes

Gene	Expression	Dist. to TSS	Distance	Link type
SMAD4		9.1 kb	Proximal	Proximity
ENSG00000289868		9.2 kb	Proximal	Proximity

Chromatin Accessibility

Genome Browser

Genomic view centred on this element. Tracks include ATAC-seq accessibility, RNA-seq expression, TF binding peaks, and element-to-gene loop arcs across the ESC → DE time course.

Transcription factors with ChIP-seq peak overlap or TOBIAS motif footprint evidence at this element.

TF Binding

79 transcription factors

AR 1 dataset

ChIP THP-1_R1881 GSE131381.AR.THP-1_R1881 154 bp overlap

ASH2L 2 datasets

ChIP Hep-G2 ENCSR508LMH.ASH2L.Hep-G2 57 bp overlap

ChIP WA01 ENCSR850KIP.ASH2L.WA01 106 bp overlap

ATF2 2 datasets

Motif DE_12h DE_12h-ATF2_MA1632.2 10 bp overlap

ChIP GM12878 ENCSR000BQK.ATF2.GM12878 97 bp overlap

ATF4 2 datasets

ChIP K-562 ENCSR145TSJ.ATF4.K-562 122 bp overlap

ChIP K562 ENCFF674KTF 239 bp overlap

Atoh1 1 dataset

Motif DE_12h DE_12h-Atoh1_MA1467.3 7 bp overlap

BRD4 1 dataset

ChIP hESC GSE33281.BRD4.hESC 61 bp overlap

CEBPG 1 dataset

ChIP K562 ENCFF651CMK 271 bp overlap

CREB1 1 dataset

Motif DE_12h DE_12h-CREB1_MA0018.5 8 bp overlap

CTCF 3 datasets

ChIP GM23338 ENCFF772DML 186 bp overlap

ChIP K-562 GSE70764.CTCF.K-562 123 bp overlap

ChIP WA01 ENCSR000DLK.CTCF.WA01 90 bp overlap

ERF::FOXO1 1 dataset

Motif DE_12h DE_12h-ERFFOXO1_MA1936.2 12 bp overlap

ETS1 1 dataset

ChIP cardiomyocyte_D0 GSE129986.ETS1.cardiomyocyte_D0 364 bp overlap

ETV2::FOXI1 1 dataset

Motif DE_12h DE_12h-ETV2FOXI1_MA1942.2 11 bp overlap

ETV5::FOXI1 1 dataset

Motif DE_12h DE_12h-ETV5FOXI1_MA1946.2 12 bp overlap

FEZF1 1 dataset

ChIP HEK293 GSE76494.FEZF1.HEK293 154 bp overlap

FIGLA 1 dataset

Motif DE_12h DE_12h-FIGLA_MA0820.2 6 bp overlap

FOXJ2::ELF1 1 dataset

Motif DE_12h DE_12h-FOXJ2ELF1_MA1952.2 11 bp overlap

FOXO1::ELF1 1 dataset

Motif DE_12h DE_12h-FOXO1ELF1_MA1953.2 13 bp overlap

FOXO1::ELK1 1 dataset

Motif DE_12h DE_12h-FOXO1ELK1_MA1954.2 13 bp overlap

FOXO1::ELK3 1 dataset

Motif DE_12h DE_12h-FOXO1ELK3_MA1955.2 13 bp overlap

FOXO1::FLI1 1 dataset

Motif DE_12h DE_12h-FOXO1FLI1_MA1956.2 13 bp overlap

GATA4 1 dataset

ChIP BJ1-hTERT_FOXA2_GATA4_Coexp GSE92491.GATA4.BJ1-hTERT_FOXA2_GATA4_Coexp 122 bp overlap

GFI1B 1 dataset

ChIP K-562 ENCSR509GDT.GFI1B.K-562 113 bp overlap

GLIS3 1 dataset

ChIP H9_plus GSE109562.GLIS3.H9_plus 283 bp overlap

HAND2 1 dataset

Motif DE_12h DE_12h-HAND2_MA1638.2 6 bp overlap

HNF4A 1 dataset

Motif DE_12h DE_12h-HNF4A_MA0114.5 9 bp overlap

HNF4G 1 dataset

Motif DE_12h DE_12h-HNF4G_MA0484.3 9 bp overlap

HNRNPK 5 datasets

ChIP Hep-G2 ENCSR519QAA.HNRNPK.Hep-G2 354 bp overlap

ChIP Hep-G2 GSE120104.HNRNPK.Hep-G2 354 bp overlap

ChIP HepG2 ENCFF493GNS 364 bp overlap

ChIP HepG2 ENCFF493GNS 291 bp overlap

ChIP HepG2 ENCFF826MXP 364 bp overlap

INSM1 1 dataset

Motif DE_12h DE_12h-INSM1_MA0155.1 12 bp overlap

IRF4 1 dataset

Motif DE_12h DE_12h-IRF4_MA1419.2 14 bp overlap

IRF7 1 dataset

Motif DE_12h DE_12h-IRF7_MA0772.2 13 bp overlap

IRF8 1 dataset

Motif DE_12h DE_12h-IRF8_MA0652.2 13 bp overlap

Irf1 1 dataset

Motif DE_12h DE_12h-Irf1_MA0050.4 11 bp overlap

JUN 3 datasets

ChIP HAEC_IL1b_4h GSE89970.JUN.HAEC_IL1b_4h 91 bp overlap

ChIP HAEC_TNFa_4h GSE89970.JUN.HAEC_TNFa_4h 119 bp overlap

ChIP K-562 ENCSR000FAH.JUN.K-562 76 bp overlap

MEF2A 1 dataset

ChIP Hep-G2 ENCSR291MJH.MEF2A.Hep-G2 67 bp overlap

Mafb 1 dataset

Motif DE_12h DE_12h-Mafb_MA0117.3 11 bp overlap

NEUROD1 1 dataset

Motif DE_12h DE_12h-NEUROD1_MA1109.2 8 bp overlap

NEUROG2 1 dataset

Motif DE_12h DE_12h-NEUROG2_MA1642.2 7 bp overlap

NFATC1 1 dataset

ChIP GM12878 ENCSR000BQL.NFATC1.GM12878 50 bp overlap

NFIA 1 dataset

ChIP K-562 GSE97661.NFIA.K-562 114 bp overlap

NFIC 1 dataset

ChIP Hep-G2 GSE108514.NFIC.Hep-G2 108 bp overlap

NFKB1 1 dataset

ChIP L1236 GSE63736.NFKB1.L1236 364 bp overlap

NFKB2 2 datasets

ChIP L1236 GSE63736.NFKB2.L1236 195 bp overlap

ChIP L1236 GSE63736.NFKB2.L1236 129 bp overlap

NR2C1 1 dataset

Motif DE_12h DE_12h-NR2C1_MA1535.2 6 bp overlap

NR2C2 1 dataset

Motif DE_12h DE_12h-NR2C2_MA1536.2 6 bp overlap

Neurod2 1 dataset

Motif DE_12h DE_12h-Neurod2_MA0668.3 8 bp overlap

Nr1H2 1 dataset

Motif DE_12h DE_12h-Nr1H2_MA1996.2 6 bp overlap

Nr1H4 1 dataset

Motif DE_12h DE_12h-Nr1H4_MA1110.3 6 bp overlap

Nr1h3 1 dataset

Motif DE_12h DE_12h-Nr1h3_MA2337.1 6 bp overlap

Nr2e1 1 dataset

Motif DE_12h DE_12h-Nr2e1_MA0676.1 9 bp overlap

PCGF1 1 dataset

ChIP WA01 GSE104690.PCGF1.WA01 319 bp overlap

PRDM6 1 dataset

ChIP HEK293 ENCSR892QHR.PRDM6.HEK293 52 bp overlap

Prdm15 1 dataset

Motif DE_12h DE_12h-Prdm15_MA1616.2 11 bp overlap

Prdm4 1 dataset

Motif DE_12h DE_12h-Prdm4_MA1647.3 11 bp overlap

RBPJ 1 dataset

Motif DE_12h DE_12h-RBPJ_MA1116.2 6 bp overlap

RELA 11 datasets

ChIP HAEC_IL1b_4h GSE89970.RELA.HAEC_IL1b_4h 142 bp overlap

ChIP HAEC_TNFa_4h GSE89970.RELA.HAEC_TNFa_4h 120 bp overlap

ChIP SGBS_TNF GSE64233.RELA.SGBS_TNF 150 bp overlap

ChIP aortic-endothelial-cell_IL1B_D13 GSE139377.RELA.aortic-endothelial-cell_IL1B_D13 117 bp overlap

ChIP aortic-endothelial-cell_IL1B_D14 GSE139377.RELA.aortic-endothelial-cell_IL1B_D14 174 bp overlap

ChIP aortic-endothelial-cell_IL1B_D16 GSE139377.RELA.aortic-endothelial-cell_IL1B_D16 95 bp overlap

ChIP aortic-endothelial-cell_IL1B_D2 GSE139377.RELA.aortic-endothelial-cell_IL1B_D2 130 bp overlap

ChIP aortic-endothelial-cell_IL1B_D21 GSE139377.RELA.aortic-endothelial-cell_IL1B_D21 142 bp overlap

ChIP aortic-endothelial-cell_IL1B_D26 GSE139377.RELA.aortic-endothelial-cell_IL1B_D26 122 bp overlap

ChIP aortic-endothelial-cell_IL1B_D39 GSE139377.RELA.aortic-endothelial-cell_IL1B_D39 122 bp overlap

ChIP aortic-endothelial-cell_IL1B_D40 GSE139377.RELA.aortic-endothelial-cell_IL1B_D40 107 bp overlap

RELB 1 dataset

ChIP L1236 GSE63736.RELB.L1236 105 bp overlap

SIN3A 1 dataset

ChIP hiPSC_IB12 GSE106870.SIN3A.hiPSC_IB12 137 bp overlap

SMAD2 1 dataset

Motif DE_12h DE_12h-SMAD2_MA1964.2 6 bp overlap

SMARCA4 1 dataset

ChIP hiPSC GSE124903.SMARCA4.hiPSC 103 bp overlap

SPI1 1 dataset

ChIP DC_96h_donorM GSE128834.SPI1.DC_96h_donorM 98 bp overlap

SPIC 1 dataset

Motif DE_12h DE_12h-SPIC_MA0687.2 13 bp overlap

SREBP2 1 dataset

ChIP monocyte_TNF GSE129202.SREBP2.monocyte_TNF 143 bp overlap

STAT1 1 dataset

ChIP CD14_INFG_LPS GSE43036.STAT1.CD14_INFG_LPS 137 bp overlap

STAT1::STAT2 1 dataset

Motif DE_12h DE_12h-STAT1STAT2_MA0517.2 13 bp overlap

STAT3 1 dataset

Motif DE_12h DE_12h-STAT3_MA0144.3 9 bp overlap

Stat2 1 dataset

Motif DE_12h DE_12h-Stat2_MA1623.2 10 bp overlap

TCF12 1 dataset

ChIP WA01 ENCSR000BIT.TCF12.WA01 72 bp overlap

TWIST1 1 dataset

Motif DE_12h DE_12h-TWIST1_MA1123.3 8 bp overlap

VEZF1 2 datasets

ChIP K-562 ENCSR189YMA.VEZF1.K-562 282 bp overlap

ChIP K562 ENCFF053XDV 364 bp overlap

ZBTB42 1 dataset

ChIP HEK293 GSE76494.ZBTB42.HEK293 130 bp overlap

ZBTB7A 2 datasets

ChIP K-562 GSE103445.ZBTB7A.K-562 118 bp overlap

ChIP K-562 GSE103445.ZBTB7A.K-562 138 bp overlap

ZEB1 1 dataset

Motif DE_12h DE_12h-ZEB1_MA0103.4 6 bp overlap

ZIM3 1 dataset

Motif DE_12h DE_12h-ZIM3_MA1709.2 11 bp overlap

ZNF281 1 dataset

ChIP K-562 GSE121133.ZNF281.K-562 259 bp overlap

ZNF398 1 dataset

ChIP H9 GSE133630.ZNF398.H9 141 bp overlap

ZNF740 2 datasets

ChIP K-562 ENCSR737UST.ZNF740.K-562 318 bp overlap

ChIP K562 ENCFF505NFV 364 bp overlap

ZNF75A 1 dataset

Motif DE_12h DE_12h-ZNF75A_MA2097.1 12 bp overlap

ZNF770 1 dataset

ChIP HepG2 ENCFF233UVH 237 bp overlap

Zfp809 1 dataset

Motif DE_12h DE_12h-Zfp809_MA2125.1 9 bp overlap